COVID Protection After Transplant-Immunosuppression Reduction
Public ClinicalTrials.gov record NCT05077254. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Study to Evaluate Antibody Response to an Additional Dose of SARS-CoV-2 Vaccination With and Without Immunosuppression Reduction in Kidney and Liver Transplant Recipients
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will enroll individuals who have: * Completed primary series of mRNA COVID-19 vaccine, and * An antibody response ≤ 2500 U/mL measured at least 30 days after the last dose of vaccine. This group of patients is at high risk for severe COVID-19 disease due to pharmacologic immunosuppression and a high prevalence of non-transplant risk factors such as obesity and diabetes.
Study identification
- NCT ID
- NCT05077254
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 48 participants
Conditions and interventions
Interventions
- Pfizer-BioNTech COVID-19 Vaccine 2023-2024 Biological
- Moderna COVID-19 Vaccine 2023-2024 Biological
- SOC IS Regimen Drug
- SOC IS Reduction Drug
Biological · Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 6, 2021 (Actual)
- Primary completion
- Feb 28, 2024 (Actual)
- Completion
- Feb 21, 2025 (Actual)
- Last update posted
- Apr 23, 2026
2021 – 2025
United States locations
- U.S. sites
- 15
- U.S. states
- 10
- U.S. cities
- 13
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of California, San Diego | San Diego | California | 92093 | — |
| University of California San Francisco Health | San Francisco | California | 94143 | — |
| Emory Healthcare | Atlanta | Georgia | 30322 | — |
| University of Illinois Health | Chicago | Illinois | 60612 | — |
| Northwestern University | Evanston | Illinois | 60208 | — |
| University of Iowa Hospitals | Iowa City | Iowa | 52242 | — |
| Ochsner Health | New Orleans | Louisiana | 70121 | — |
| Johns Hopkins Institute for Clinical and Translational Research: Broadway Adult Outpatient Clinical Research Unit | Baltimore | Maryland | 21287 | — |
| NYU Langone Transplant Institute | New York | New York | 10016 | — |
| Mt. Sinai Hospital | New York | New York | 10029 | — |
| Weill Cornell Medicine | New York | New York | 10065 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| University of Pittsburgh | Pittsburgh | Pennsylvania | 15260 | — |
| Houston Methodist | Houston | Texas | 77030 | — |
| University of Wisconsin-Madison | Madison | Wisconsin | 53706 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05077254, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 23, 2026 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05077254 live on ClinicalTrials.gov.