A Study to Investigate Safety and Tolerability of TransCon IL-2 β/γ Alone or in Combination With Pembrolizumab and/or TransCon TLR7/8 Agonist or Other Anticancer Therapies in Adult Participants With Locally Advanced or Metastatic Solid Tumor Malignancies
Public ClinicalTrials.gov record NCT05081609. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
IL Believe: A Phase 1/2, Open-label, Dose Escalation and Dose Expansion Study to Investigate the Safety and Tolerability of TransCon IL-2 β/γ Alone or in Combination With Pembrolizumab, TransCon TLR7/8 Agonist, or Other Anticancer Therapies, in Adult Participants With Locally Advanced or Metastatic Solid Tumor Malignancies
Study identification
- NCT ID
- NCT05081609
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Lead sponsor
- Ascendis Pharma Oncology Division A/S
- Industry
- Enrollment
- 320 participants
Conditions and interventions
Conditions
- 2L+ Cervical Cancer
- Advanced Solid Tumor
- Locally Advanced Solid Tumor
- Metastatic Solid Tumor
- Neoadjuvant Melanoma
- Neoadjuvant Non-Small Cell Lung Cancer
- Platinum-resistant Ovarian Cancer
- Post Anti-PD-(L)1 Non-Small Cell Lung Cancer
- Post Anti-PD-(L)1 Small Cell Lung Cancer
- Post Anti-PD-1 Melanoma
- Second or Third Line (2L/3L) Cervical Cancer
- Third Line or Later (3L+) HER2+ Breast Cancer
- Third-line or Later (3L+) Platinum-resistant Ovarian Cancer (PROC)
Interventions
- Chemotherapy drug Drug
- Pembrolizumab Drug
- Surgery Procedure
- TransCon IL-2 β/γ Drug
- TransCon TLR7/8 Agonist Drug
- Trastuzumab Drug
- Trastuzumab emtansine (T-DM1) Drug
Drug · Procedure
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Not listed
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 10, 2022
- Primary completion
- Jul 31, 2027
- Completion
- Jul 31, 2029
- Last update posted
- Feb 23, 2026
2022 – 2029
United States locations
- U.S. sites
- 14
- U.S. states
- 12
- U.S. cities
- 13
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Ascendis Pharma Investigational Site | Los Angeles | California | 90048 | — |
| Ascendis Pharma Investigational Site | Los Angeles | California | 90067 | — |
| Ascendis Pharma Investigational Site | Springfield | Illinois | 62702 | — |
| Ascendis Pharma Investigational Site | Louisville | Kentucky | 40202 | — |
| Ascendis Pharma Investigational Site | Boston | Massachusetts | 02114 | — |
| Ascendis Pharma Investigational Site | Morristown | New Jersey | 07960 | — |
| Ascendis Pharma Investigational Site | New York | New York | 10032 | — |
| Ascendis Pharma Investigational Site | Huntersville | North Carolina | 28078 | — |
| Ascendis Pharma Investigational Site | Canton | Ohio | 44718 | — |
| Ascendis Pharma Investigational Site | Cincinnati | Ohio | 45219 | — |
| Ascendis Pharma Investigational Site | Oklahoma City | Oklahoma | 73104 | — |
| Ascendis Pharma Investigational Site | Pittsburgh | Pennsylvania | 15232 | — |
| Ascendis Pharma Investigational Site | Nashville | Tennessee | 37203 | — |
| Ascendis Pharma Investigational Site | Richmond | Virginia | 23298 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 54 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05081609, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 23, 2026 · Synced Apr 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05081609 live on ClinicalTrials.gov.