A Multicenter Study of Continued Current Therapy vs Transition to Ofatumumab After Neurofilament (NfL) Elevation
Public ClinicalTrials.gov record NCT05090371. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Open Label, Multi-center, Active-comparator Study to Assess Efficacy, Safety & Tolerability of Ofatumumab 20mg sc Monthly Versus Continued Current Therapy in Relapsing-remitting Multiple Sclerosis After Elevation of Serum Neurofilament Light Levels (SOSTOS)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will evaluate if relapsing-remitting MS patients that have not had a relapse in the past year would benefit from a switch to ofatumumab versus staying on their continued current therapy. This study will also look at whether an elevated serum neurofilament light (NfL) level predicts enhanced benefit from a switch to ofatumumab.
Study identification
- NCT ID
- NCT05090371
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 4
- Enrollment
- 136 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 50 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 2, 2022 (Actual)
- Primary completion
- Apr 13, 2027 (Estimated)
- Completion
- Apr 13, 2027 (Estimated)
- Last update posted
- May 29, 2026
2022 – 2027
United States locations
- U.S. sites
- 37
- U.S. states
- 19
- U.S. cities
- 37
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Alabama Neurology Associates PC | Birmingham | Alabama | 35209 | — |
| North Central Neurology Associates PC | Cullman | Alabama | 35058 | — |
| Radiant Research Chandler | Chandler | Arizona | 85224 | — |
| Arizona Neuroscience Research LLC | Phoenix | Arizona | 85032 | — |
| University of California at Los Angeles | Torrance | California | 90509-2004 | — |
| Neurology of Central FL Res Ctr | Altamonte Springs | Florida | 32714 | — |
| S And D Clinical Research | Cape Coral | Florida | 33904 | — |
| Homestead Assoc In Research Inc | Homestead | Florida | 33033 | — |
| Neurology Associates PA | Maitland | Florida | 32751 | — |
| Orlando Health Clinical Trials | Orlando | Florida | 32806 | — |
| Emerald Coast Neurology | Pensacola | Florida | 32514 | — |
| University Of South Florida | Tampa | Florida | 33612 | — |
| Kootenai Health | Coeur d'Alene | Idaho | 83815 | — |
| Neuro Medial Clinic of Central Louisiana | Alexandria | Louisiana | 71301 | — |
| International Neurorehab Institute | Lutherville | Maryland | 21093 | — |
| Reliant Medical Group | Worcester | Massachusetts | 01608 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202-2689 | — |
| Memorial Healthcare | Owosso | Michigan | 48867 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216-4505 | — |
| St Barnabas Medical Center | Livingston | New Jersey | 07039 | — |
| Jersey Shore University Medical Ctr | Neptune City | New Jersey | 07753 | — |
| SUNY Upstate Medical Center | Syracuse | New York | 13210 | — |
| University Of NC At Chapel Hill | Chapel Hill | North Carolina | 27599 9500 | — |
| Piedmont HealthCare | Charlotte | North Carolina | 28210 | — |
| Velocity Clinical Research | Raleigh | North Carolina | 27607 | — |
| Palmetto Clinical Research | Summerville | South Carolina | 29485 | — |
| Sibyl Wray MD Neurology PC | Knoxville | Tennessee | 37922 | — |
| Clinical Trial Network | Houston | Texas | 77074 | — |
| Neuro Mind Clinical Trials Ltd Co | Katy | Texas | 77449 | — |
| Covenant Medical Group | Lubbock | Texas | 79410 | — |
| West Texas Cancer Center | Odessa | Texas | 79761 | — |
| Tranquil Clinical Research | Webster | Texas | 77598 | — |
| Sentara Neuroscience Institute | Virginia Beach | Virginia | 23456 | — |
| Evergreen Health Multiple Sclerosis Center | Kirkland | Washington | 98034 | — |
| Swedish Medical Center | Seattle | Washington | 98122-4379 | — |
| Aurora BayCare Medical Center | Green Bay | Wisconsin | 54311 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 6 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05090371, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 29, 2026 · Synced Oct 24, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05090371 live on ClinicalTrials.gov.