ClinicalTrials.gov record
A Study of Vericiguat (MK-1242) in Participants With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-035)
ClinicalTrials.gov ID: NCT05093933
Public ClinicalTrials.gov record NCT05093933. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Pivotal Phase 3 Randomized, Placebo-controlled Clinical Study to Evaluate the Efficacy and Safety of the sGC Stimulator Vericiguat/MK-1242 in Adults With Chronic Heart Failure With Reduced Ejection Fraction
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the efficacy and safety of vericiguat in participants with chronic heart failure with reduced ejection fraction (HFrEF), specifically those with symptomatic chronic HFrEF who have not had a recent hospitalization for heart failure or need for outpatient intravenous (IV) diuretics. The primary hypothesis is that vericiguat is superior to placebo in reducing the risk of cardiovascular death or heart failure hospitalization.
Study identification
- NCT ID
- NCT05093933
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 6,106 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 2, 2021 (Actual)
- Primary completion
- Nov 20, 2024 (Actual)
- Completion
- Feb 5, 2025 (Actual)
- Last update posted
- Dec 19, 2025
2021 – 2025
United States locations
- U.S. sites
- 84
- U.S. states
- 27
- U.S. cities
- 77
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Advanced Cardiovascular - Alexander City ( Site 0038) | Alexander City | Alabama | 35010 | — |
| University of Alabama at Birmingham - School of Medicine-Cardiology ( Site 0153) | Birmingham | Alabama | 35294 | — |
| Heart Center Research, LLC ( Site 0156) | Huntsville | Alabama | 35801 | — |
| Mercy Gilbert Medical Center-Dignity Health Cardiology ( Site 0075) | Gilbert | Arizona | 85297 | — |
| Valley Clinical Trials, Inc. ( Site 0085) | Covina | California | 91723 | — |
| VA West Los Angeles Medical Center-Cardiology ( Site 0149) | Los Angeles | California | 90073 | — |
| Valley Clinical Trials Inc ( Site 0006) | Northridge | California | 91325 | — |
| Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center ( Site 0010) | Torrance | California | 90502 | — |
| Blue Coast Research Center ( Site 0053) | Vista | California | 92081 | — |
| Excel Medical Clinical Trials ( Site 0008) | Boca Raton | Florida | 33434 | — |
| Universal Axon Clinical Research, LLC ( Site 0022) | Doral | Florida | 33166 | — |
| Holy Cross Hospital ( Site 0100) | Fort Lauderdale | Florida | 33308 | — |
| Indago Research and Health Center Inc ( Site 0011) | Hialeah | Florida | 33012 | — |
| South Florida Research Solutions ( Site 0058) | Hollywood | Florida | 33021 | — |
| University of Florida - Jacksonville ( Site 0169) | Jacksonville | Florida | 32209 | — |
| East Coast Institute for Research, LLC ( Site 0047) | Jacksonville | Florida | 32216 | — |
| Cardiovascular Research Center of South Florida ( Site 0074) | Miami | Florida | 33173 | — |
| ProLive Medical Research ( Site 0032) | Miami | Florida | 33175 | — |
| Peace River Cardiovascular Center ( Site 0088) | Port Charlotte | Florida | 33952 | — |
| BAYCARE MEDICAL GROUP ( Site 0099) | Safety Harbor | Florida | 34695 | — |
| East Coast Institute for Research - St. Augustine ( Site 0016) | Saint Augustine | Florida | 32086 | — |
| Cardiovascular Center of Sarasota ( Site 0154) | Sarasota | Florida | 34239 | — |
| Emory University School of Medicine ( Site 0123) | Atlanta | Georgia | 30322 | — |
| IACT Health ( Site 0106) | Columbus | Georgia | 31904 | — |
| NSC Research ( Site 0068) | Johns Creek | Georgia | 30024 | — |
| Georgia Arrhythmia Consultants and Research Institute ( Site 0042) | Macon | Georgia | 31201 | — |
| Cardiovascular Consultants of South Georgia, LLC ( Site 0137) | Thomasville | Georgia | 31792 | — |
| Mount Sinai Hospital ( Site 0050) | Chicago | Illinois | 60608 | — |
| Chicago Medical Research ( Site 0086) | Hazel Crest | Illinois | 60429 | — |
| OSF Healthcare Cardiovascular Institute ( Site 0122) | Peoria | Illinois | 61614 | — |
| Methodist Medical Center of Illinois ( Site 0098) | Peoria | Illinois | 61636 | — |
| Franciscan Physician Network - Indiana Heart Physicians ( Site 0087) | Indianapolis | Indiana | 46237 | — |
| The Heart Center of Lake County Research Institute-Research ( Site 0147) | Merrillville | Indiana | 46410 | — |
| Cardiovascular Research of Northwest Indiana ( Site 0036) | Munster | Indiana | 46321 | — |
| Reid Physician Associates ( Site 0054) | Richmond | Indiana | 47374 | — |
| University of Iowa ( Site 0005) | Iowa City | Iowa | 52242 | — |
| Alliance for Multispecialty Research, LLC ( Site 0143) | Wichita | Kansas | 67207 | — |
| Norton Healthcare-Norton Heart Specialist ( Site 0062) | Louisville | Kentucky | 40205 | — |
| Cambridge Medical Trials ( Site 0041) | Alexandria | Louisiana | 71301 | — |
| Louisiana Heart Center - Hammond ( Site 0004) | Hammond | Louisiana | 70403 | — |
| The Heart Clinic - Hammond ( Site 0155) | Hammond | Louisiana | 70403 | — |
| Cardiovascular Institute of the South ( Site 0072) | Houma | Louisiana | 70360 | — |
| Cardiovascular Institute of the South, 3 ( Site 0096) | Lafayette | Louisiana | 70503 | — |
| IMA Clinical Research ( Site 0112) | Monroe | Louisiana | 71201 | — |
| Cardiovascular Institute of the South ( Site 0081) | Opelousas | Louisiana | 70570 | — |
| Maryland Cardiovascular Specialists ( Site 0056) | Baltimore | Maryland | 21229 | — |
| Capitol Cardiology Associates - Lanham Office-Maryland Research Centers ( Site 0167) | Lanham | Maryland | 20706 | — |
| Ascension Providence Hospital ( Site 0094) | Southfield | Michigan | 48075 | — |
| Phillips Medical Services ( Site 0070) | Jackson | Mississippi | 39209 | — |
| The University of Mississippi Medical Center-Cardiovascular ( Site 0073) | Jackson | Mississippi | 39216 | — |
| University of Missouri Hospital ( Site 0163) | Columbia | Missouri | 65212 | — |
| Washington University-Department of Medicine ( Site 0044) | St Louis | Missouri | 63110 | — |
| St. Louis Heart and Vascular, P.C.-Clinical Trials Unit ( Site 0029) | St Louis | Missouri | 63136 | — |
| Logan Health Research ( Site 0017) | Kalispell | Montana | 59901 | — |
| Renown Regional Medical Center-Renown Institute for Heart and Vascular Health ( Site 0168) | Reno | Nevada | 89502 | — |
| Amici Clinical Research LLC-Research ( Site 0037) | Raritan | New Jersey | 08869 | — |
| The Valley Hospital ( Site 0035) | Ridgewood | New Jersey | 07450 | — |
| Cardiovascular Associates of the Delaware Valley ( Site 0097) | Washington Township | New Jersey | 08080 | — |
| Erie County Medical Center ( Site 0160) | Buffalo | New York | 14215 | — |
| New York Presbyterian Medical Group Hudson Valley Cardiology ( Site 0127) | Cortlandt Manor | New York | 10567 | — |
| Icahn School of Medicine at Mount Sinai ( Site 0161) | New York | New York | 10029-5674 | — |
| CHEAR Center LLC ( Site 0009) | The Bronx | New York | 10455 | — |
| Southeastern Cardiology and Cardiovascular-Duke HC CRU - Lumberton ( Site 0134) | Lumberton | North Carolina | 28358 | — |
| Accellacare - Wilmington ( Site 0090) | Wilmington | North Carolina | 28401 | — |
| Aultman Hospital-Cardiology Clinical Trials ( Site 0064) | Canton | Ohio | 44710 | — |
| University of Cincinnati Medical Center-Cardiology ( Site 0071) | Cincinnati | Ohio | 45219 | — |
| ProMedica Toledo Hospital-ProMedica Heart Failure Clinic ( Site 0061) | Toledo | Ohio | 43606 | — |
| Doylestown Hospital-Cardiology ( Site 0030) | Doylestown | Pennsylvania | 18901 | — |
| Accellacare - Charleston ( Site 0141) | Charleston | South Carolina | 29464 | — |
| Apex Research Foundation ( Site 0001) | Jackson | Tennessee | 38301 | — |
| Vanderbilt University Medical Center-Vanderbilt Heart and Vascular Institue ( Site 0060) | Nashville | Tennessee | 37232 | — |
| Dallas VA Medical Center ( Site 0084) | Dallas | Texas | 75216 | — |
| Southwest Family Medicine Associates ( Site 0131) | Dallas | Texas | 75235 | — |
| Medresearch Inc ( Site 0043) | El Paso | Texas | 79935 | — |
| West Houston Area Clinical Trial Consultants ( Site 0014) | Houston | Texas | 77094 | — |
| South Texas Cardiovascular Consultants, PLLC-Research ( Site 0024) | Kerrville | Texas | 78028 | — |
| South Texas Cardiovascular Consultants, PLLC-Research ( Site 0020) | San Antonio | Texas | 78201 | — |
| Tyler Cardiovascular Consultants ( Site 0039) | Tyler | Texas | 75701 | — |
| INOVA Fairfax Medical Campus ( Site 0136) | Falls Church | Virginia | 22042 | — |
| Carient Heart & Vascular - Manassas ( Site 0059) | Manassas | Virginia | 20109 | — |
| Sentara Norfolk General Hospital ( Site 0114) | Norfolk | Virginia | 23507 | — |
| Dominion Medical Associates, Inc. ( Site 0089) | Richmond | Virginia | 23219 | — |
| Pulse Heart Institute - Puyallup ( Site 0119) | Puyallup | Washington | 98372 | — |
| MultiCare Health System-MultiCare Cardiology - Inland Northwest ( Site 0102) | Spokane | Washington | 99204 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 435 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05093933, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 19, 2025 · Synced Oct 23, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05093933 live on ClinicalTrials.gov.