ClinicalTrials.gov record
Study Assessing the Long-term Effect of Dupilumab on Prevention of Lung Function Decline in Adult Patients With Uncontrolled Moderate to Severe Asthma
ClinicalTrials.gov ID: NCT05097287
Public ClinicalTrials.gov record NCT05097287. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Blind, Placebo Controlled Study Assessing the Long-term Effect of Dupilumab on Prevention of Lung Function Decline in Patients With Uncontrolled Moderate to Severe Asthma
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is an interventional, randomized, parallel group, treatment, Phase 3b/4, double blind, 2-arm study to assess the effect of dupilumab compared to standard of care therapy on preventing or slowing the rate of lung function decline in adult patients with uncontrolled moderate to severe asthma. The estimated duration is 4±1 weeks of screening and run-in period, followed by a 3-year double blinded treatment period. There will be a post-treatment follow-up (FU) period up to 12 weeks.
Study identification
- NCT ID
- NCT05097287
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 4
- Enrollment
- 1,339 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 16, 2021 (Actual)
- Primary completion
- Mar 16, 2027 (Estimated)
- Completion
- Jun 8, 2029 (Estimated)
- Last update posted
- Apr 16, 2026
2021 – 2029
United States locations
- U.S. sites
- 75
- U.S. states
- 21
- U.S. cities
- 69
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Cullman Research Center- Site Number : 8400001 | Cullman | Alabama | 35055 | — |
| Shoals Primary Care - Sheffield- Site Number : 8400015 | Sheffield | Alabama | 35660 | — |
| Chandler Clinical Research Trials- Site Number : 8400147 | Chandler | Arizona | 85224 | — |
| Pulmonary Associates - Deer Valley Office- Site Number : 8400155 | Phoenix | Arizona | 85027 | — |
| Medical Advancement Center of Arizona (MACOA)- Site Number : 8400130 | Phoenix | Arizona | 85051 | — |
| Del Sol Research Management - Tucson- Site Number : 8400017 | Tucson | Arizona | 85715 | — |
| Kern Allergy and Medical Research- Site Number : 8400037 | Bakersfield | California | 93301 | — |
| Vitality Clinical Research- Site Number : 8400142 | Beverly Hills | California | 90211 | — |
| Ascada Research - Fullerton- Site Number : 8400076 | Fullerton | California | 92835 | — |
| Allergy and Asthma Specialists Medical Group- Site Number : 8400162 | Huntington Beach | California | 92647 | — |
| Newport Native MD- Site Number : 8400054 | Newport Beach | California | 92663 | — |
| Prospective Research Innovations- Site Number : 8400131 | Rancho Cucamonga | California | 91730 | — |
| Mercy Medical Group - Midtown- Site Number : 8400164 | Sacramento | California | 95816 | — |
| Integrated Research of Inland- Site Number : 8400156 | Upland | California | 91786 | — |
| Allianz Research Institute- Site Number : 8400018 | Westminster | California | 92683 | — |
| Woodland Clinic - Woodland- Site Number : 8400171 | Woodland | California | 95695 | — |
| Central Florida Pulmonary Group - Altamonte Springs- Site Number : 8400035 | Altamonte Springs | Florida | 32701 | — |
| Florida Center for Allergy & Asthma Research- Site Number : 8400032 | Aventura | Florida | 33180 | — |
| Beautiful Minds Clinical Research Center- Site Number : 8400141 | Cutler Bay | Florida | 33157 | — |
| Omega Research Consultants - Debary - North Charles Richard Beall Boulevard- Site Number : 8400023 | DeBary | Florida | 32713 | — |
| Florida Lung, Asthma and Sleep Specialists (FLASS) - Polynesian- Site Number : 8400098 | Kissimmee | Florida | 34746 | — |
| Ivetmar Medical Group- Site Number : 8400063 | Miami | Florida | 33155 | — |
| My Preferred Research- Site Number : 8400073 | Miami | Florida | 33155 | — |
| Research Institute of South Florida- Site Number : 8400079 | Miami | Florida | 33173 | — |
| Floridian Clinical Research - Miami Lakes- Site Number : 8400091 | Miami Lakes | Florida | 33016 | — |
| Heuer M.D. Research- Site Number : 8400024 | Orlando | Florida | 32819 | — |
| JSV Clinical Research- Site Number : 8400150 | Tampa | Florida | 33634 | — |
| Appalachian Clinical Research- Site Number : 8400129 | Adairsville | Georgia | 30103 | — |
| Alpha Clinical Research Group - Dunwoody- Site Number : 8400116 | Dunwoody | Georgia | 30350 | — |
| Aeroallergy Research Laboratory- Site Number : 8400114 | Savannah | Georgia | 31406 | — |
| Rush University Medical Center- Site Number : 8400146 | Chicago | Illinois | 60612 | — |
| NorthShore University Health System - Endeavor Health Medical Group - Skokie - Woods Drive- Site Number : 8400138 | Skokie | Illinois | 60077 | — |
| Family Allergy & Asthma - Louisville - Goss Avenue- Site Number : 8400160 | Louisville | Kentucky | 40217 | — |
| Allergy and Asthma Specialist- Site Number : 8400007 | Owensboro | Kentucky | 42301 | — |
| Avant Research Associates - Crowley- Site Number : 8400117 | Crowley | Louisiana | 70526 | — |
| Investigational Site Number : 3560016 | Houma | Louisiana | 70360-4413 | — |
| Tandem Clinical Research - Metairie- Site Number : 8400163 | Metairie | Louisiana | 70006 | — |
| Javara Privia Mid-Atlantic - Annapolis- Site Number : 8400087 | Annapolis | Maryland | 21401 | — |
| Urgent Care Clinical Trials and KUR Research- Site Number : 8400169 | Columbia | Maryland | 21045 | — |
| Chesapeake Clinical Research - White Marsh- Site Number : 8400119 | White Marsh | Maryland | 21162 | — |
| Genesis Clinical Research - Fall River- Site Number : 8400050 | Fall River | Massachusetts | 02723 | — |
| University of Michigan Health System - Ann Arbor- Site Number : 8400030 | Ann Arbor | Michigan | 48109 | — |
| Revival Research Institute - Dearborn- Site Number : 8400097 | Dearborn | Michigan | 48126 | — |
| Revive Research Institute - Lathrup Village- Site Number : 8400100 | Lathrup Village | Michigan | 48076 | — |
| Romedica- Site Number : 8400043 | Rochester | Michigan | 48307 | — |
| Great Lakes Research Institute Site Number : 8400111 | Southfield | Michigan | 48075-5400 | — |
| Great Lakes Research Institute - Southfield- Site Number : 8400111 | Southfield | Michigan | 48075 | — |
| Allergy & Immunology Associates of Ann Arbor- Site Number : 8400107 | Ypsilanti | Michigan | 48197 | — |
| The Asthma and Allergy Center- Site Number : 8400055 | Bellevue | Nebraska | 68123 | — |
| Jersey City Breathing Center: Elamir Mazhar- Site Number : 8400143 | Jersey City | New Jersey | 07304 | — |
| Urban Health Plan- Site Number : 8400144 | The Bronx | New York | 10459 | — |
| Clinical Research Of Gastonia- Site Number : 8400012 | Gastonia | North Carolina | 28054 | — |
| Advanced Respiratory and Sleep Medicine - Huntersville- Site Number : 8400056 | Huntersville | North Carolina | 28078 | — |
| Lapis Clinical Research - Mooresville- Site Number : 8400112 | Mooresville | North Carolina | 28117 | — |
| Southeastern Research Center- Site Number : 8400153 | Winston-Salem | North Carolina | 27103 | — |
| Asthma & Allergy Center - Toledo- Site Number : 8400051 | Toledo | Ohio | 43617 | — |
| St. Luke's University Hospital- Site Number : 8400099 | Bethlehem | Pennsylvania | 18015 | — |
| Temple University Hospital- Site Number : 8400038 | Philadelphia | Pennsylvania | 19140 | — |
| Allergy & Clinical Immunology Associates Pittsburgh- Site Number : 8400042 | Pittsburgh | Pennsylvania | 15241 | — |
| Bogan Sleep Consultants- Site Number : 8400102 | Columbia | South Carolina | 29201 | — |
| Allergic Disease and Asthma Center (ADAC)- Site Number : 8400026 | Greenville | South Carolina | 29607 | — |
| Main Street Physician's Care- Site Number : 8400077 | Little River | South Carolina | 29566 | — |
| National Allergy and Asthma - North Charleston - Northside Drive- Site Number : 8400092 | North Charleston | South Carolina | 29420 | — |
| Health Concepts- Site Number : 8400006 | Rapid City | South Dakota | 57702 | — |
| REX Clinical Trials - Beaumont- Site Number : 8400135 | Beaumont | Texas | 77701 | — |
| South Texas Medical Research Institute - TTS Research- Site Number : 8400009 | Boerne | Texas | 78006 | — |
| Discovery Clinical Trials - Dallas- Site Number : 8400123 | Dallas | Texas | 75225 | — |
| IntraCare- Site Number : 8400003 | Dallas | Texas | 75254 | — |
| C & R Research Services - Houston- Site Number : 8400067 | Houston | Texas | 77022 | — |
| Clear Brook Medical Associates- Site Number : 8400080 | Houston | Texas | 77089 | — |
| Metroplex Pulmonary and Sleep Center- Site Number : 8400014 | McKinney | Texas | 75069 | — |
| Andante Research- Site Number : 8400140 | San Antonio | Texas | 78229 | — |
| DM Clinical Research - 710 Lawrence Street- Site Number : 8400103 | Tomball | Texas | 77375 | — |
| Burke Internal Medicine and Research- Site Number : 8400170 | Burke | Virginia | 22015 | — |
| University of Virginia- Site Number : 8400082 | Charlottesville | Virginia | 22908 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 174 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05097287, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 16, 2026 · Synced Oct 16, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05097287 live on ClinicalTrials.gov.