A Study of Zanubrutinib Plus Anti-CD20 Versus Lenalidomide Plus Rituximab in Participants With Relapsed/Refractory Follicular or Marginal Zone Lymphoma
Public ClinicalTrials.gov record NCT05100862. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3 Randomized, Open-Label Multicenter Study of Zanubrutinib (BGB-3111) Plus Anti-CD20 Antibodies Versus Lenalidomide Plus Rituximab in Patients With Relapsed/Refractory Follicular or Marginal Zone Lymphoma
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of the study is to compare the efficacy of zanubrutinib plus obinutuzumab versus lenalidomide plus rituximab (R\^2) in participants with relapsed/refractory (R/R) follicular lymphoma (FL), as measured by progression-free survival as determined by an independent review committee in accordance with the 2014 modification of the International Working Group on non-Hodgkin lymphoma (NHL) Criteria based on n positron emission tomography and computed tomography (PET/CT), and to compare the efficacy of zanubrutinib plus rituximab versus R\^2 in participants with R/R marginal zone lymphoma (MZL), as measured by progression free survival (PFS) assessed by IRC in accordance with CT-based Lugano 2014 Criteria.
Study identification
- NCT ID
- NCT05100862
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 799 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 10, 2022 (Actual)
- Primary completion
- Jul 2028 (Estimated)
- Completion
- Jun 2030 (Estimated)
- Last update posted
- Oct 15, 2026
2022 – 2030
United States locations
- U.S. sites
- 50
- U.S. states
- 25
- U.S. cities
- 46
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Ucsf Fresno University of California San Francisco Fresno | Fresno | California | 93730-3595 | — |
| Kaiser Permanente Southern California | Irvine | California | 92618-3734 | — |
| Cancer and Blood Specialty Clinic | Los Alamitos | California | 90720-3302 | — |
| Los Angeles Cancer Network | Los Angeles | California | 90017-4803 | — |
| Valkyrie Clinical Trials | Los Angeles | California | 90067-2011 | — |
| UCLA Hematologyoncology | Los Angeles | California | 90095-3075 | — |
| Scripps Health | San Diego | California | 92103-2106 | — |
| Sharp Healthcare Sharp Memorial Hospital | San Diego | California | 92123-2701 | — |
| Baptist Md Anderson Cancer Center | Jacksonville | Florida | 32207-8432 | — |
| Ascension Sacred Heart | Pensacola | Florida | 32504-8615 | — |
| Northwest Georgia Oncology Centers Marietta | Marietta | Georgia | 30060-1152 | — |
| Cancer Care Specialists of Illinois | OFallon | Illinois | 62269 | — |
| Fort Wayne Medical Oncology and Hematology | Fort Wayne | Indiana | 46804 | — |
| Mission Cancer and Blood | Waukee | Iowa | 50263 | — |
| Cotton Oneil Cancer Center | Topeka | Kansas | 66606-1535 | — |
| Cancer Center of Kansas | Wichita | Kansas | 67214-3728 | — |
| Baptist Health Lexington | Lexington | Kentucky | 40503-1466 | — |
| Christus Highland Cancer Treatment Center | Shreveport | Louisiana | 71105-6800 | — |
| Luminis Health Anne Arundel Medical Center | Annapolis | Maryland | 21401 | — |
| The University of Maryland Greenebaum Comprehensive Cancer Center | Baltimore | Maryland | 21201 | — |
| Ascension St Agnes Hospital | Baltimore | Maryland | 21229-5201 | — |
| American Oncology Partners of Maryland Pa | Bethesda | Maryland | 20817-7847 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202-2608 | — |
| Corewell Health the Michigan Cancer Consortium | Grand Rapids | Michigan | 49503-2560 | — |
| Hattiesburg Hematology and Oncology Clinic | Hattiesburg | Mississippi | 39401-7233 | — |
| University of Missouri Hospital Ellis Fischel Cancer Center | Columbia | Missouri | 65212-1000 | — |
| Oncology Hematology Associates | Springfield | Missouri | 65807-5288 | — |
| St Vincent Frontier Cancer Center | Billings | Montana | 59102-6746 | — |
| Nebraska Cancer Specialists | Omaha | Nebraska | 68130-2042 | — |
| Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada | 89169-3321 | — |
| Iyengar Hematology Oncology Medical Center Pa | Bayonne | New Jersey | 07002-4654 | — |
| Summit Medical Group | Florham Park | New Jersey | 07932-1049 | — |
| New York Cancer and Blood Specialists | Shirley | New York | 11967 | — |
| Suny Upstate Medical University | Syracuse | New York | 13210-2306 | — |
| North Shore Hematology Oncology Associates Eccc Bronx | The Bronx | New York | 10469-5930 | — |
| Optum Medical Care, Pc | Westbury | New York | 11590-5119 | — |
| Levine Cancer Institute Wake Forest | Charlotte | North Carolina | 28204-2990 | — |
| Oncology Hematology Care Clinical Trials, Llc | Cincinnati | Ohio | 45245-1995 | — |
| Va Northeast Ohio Healthcare System | Cleveland | Ohio | 44106-1702 | — |
| Toledo Clinic Cancer Center | Toledo | Ohio | 43623-3536 | — |
| Mainline Health Lankenau Institute For Medical Research | Wynnewood | Pennsylvania | 19096 | — |
| Cancer Care Associates of York | York | Pennsylvania | 17403-5049 | — |
| Prairie Lakes Healthcare System | Watertown | South Dakota | 57201-1548 | — |
| Tennessee Oncology Nashville St Thomas Midtown Clinic | Nashville | Tennessee | 37205 | — |
| Texas Oncology Baylor Charles A Sammons Cancer Center | Dallas | Texas | 75246-2003 | — |
| Md Anderson Cancer Center | Houston | Texas | 77030-3907 | — |
| Northeast Texas Cancer and Research Institute | Tyler | Texas | 75702-7522 | — |
| University of Washington | Seattle | Washington | 98195 | — |
| Medical Oncology Associates | Spokane | Washington | 99208-1129 | — |
| Northwest Medical Specialties | Tacoma | Washington | 98405 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 214 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05100862, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 15, 2026 · Synced Oct 28, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05100862 live on ClinicalTrials.gov.