A Study of Zanubrutinib Plus Anti-CD20 Versus Lenalidomide Plus Rituximab in Participants With Relapsed/Refractory Follicular or Marginal Zone Lymphoma

ClinicalTrials.gov ID: NCT05100862

Public ClinicalTrials.gov record NCT05100862. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 8, 2026, 8:08 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3 Randomized, Open-Label Multicenter Study of Zanubrutinib (BGB-3111) Plus Anti-CD20 Antibodies Versus Lenalidomide Plus Rituximab in Patients With Relapsed/Refractory Follicular or Marginal Zone Lymphoma

Study identification

NCT ID: NCT05100862
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: BeiGene; Industry
Enrollment: 780 participants

Conditions and interventions

Conditions

Interventions

Lenalidomide Drug
Obinutuzumab Drug
Rituximab Drug
Zanubrutinib Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Mar 9, 2022
Primary completion: Jun 30, 2028
Completion: May 31, 2030
Last update posted: Apr 21, 2026

2022 – 2030

United States locations

U.S. sites: 49
U.S. states: 24
U.S. cities: 45

Facility	City	State	ZIP	Site status
Ucsf Fresno University of California San Francisco Fresno	Fresno	California	93730-3595	Active, not recruiting
Kaiser Permanente Southern California	Irvine	California	92618-3734	Completed
Cancer and Blood Specialty Clinic	Los Alamitos	California	90720-3302	Active, not recruiting
Los Angeles Cancer Network	Los Angeles	California	90017-4803	Active, not recruiting
Valkyrie Clinical Trials	Los Angeles	California	90067-2011	Active, not recruiting
UCLA Hematologyoncology	Los Angeles	California	90095-3075	Completed
Scripps Health	San Diego	California	92103-2106	Completed
Sharp Healthcare Sharp Memorial Hospital	San Diego	California	92123-2701	Active, not recruiting
Baptist Md Anderson Cancer Center	Jacksonville	Florida	32207-8432	Completed
Ascension Sacred Heart	Pensacola	Florida	32504-8615	Completed
Northwest Georgia Oncology Centers Marietta	Marietta	Georgia	30060-1152	Active, not recruiting
Cancer Care Specialists of Illinois	Decatur	Illinois	62526-5858	Completed
Fort Wayne Medical Oncology and Hematology	Fort Wayne	Indiana	46804	Active, not recruiting
Mission Cancer and Blood	Waukee	Iowa	50263	Active, not recruiting
Cotton Oneil Cancer Center	Topeka	Kansas	66606-1535	Completed
Cancer Center of Kansas	Wichita	Kansas	67214-3728	Active, not recruiting
Baptist Health Lexington	Lexington	Kentucky	40503-1466	Active, not recruiting
Christus Highland Cancer Treatment Center	Shreveport	Louisiana	71105-6800	Active, not recruiting
Luminis Health Anne Arundel Medical Center	Annapolis	Maryland	21401	Completed
University of Maryland Greenebaum Comprehensive Cancer Center	Baltimore	Maryland	21201-1544	Active, not recruiting
Ascension St Agnes Hospital	Baltimore	Maryland	21229-5201	Completed
American Oncology Partners of Maryland Pa	Bethesda	Maryland	20817-7847	Active, not recruiting
Henry Ford Hospital	Detroit	Michigan	48202-2608	Active, not recruiting
Corewell Health the Michigan Cancer Consortium	Grand Rapids	Michigan	49503-2560	Active, not recruiting
Hattiesburg Hematology and Oncology Clinic	Hattiesburg	Mississippi	39401-7233	Active, not recruiting
University of Missouri Hospital, Ellis Fischel Cancer Center	Columbia	Missouri	65212-1000	Active, not recruiting
Oncology Hematology Associates	Springfield	Missouri	65807-5288	Active, not recruiting
St Vincent Frontier Cancer Center	Billings	Montana	59102	Completed
Nebraska Cancer Specialists	Omaha	Nebraska	68130-2042	Active, not recruiting
Comprehensive Cancer Centers of Nevada	Las Vegas	Nevada	89169-3321	Completed
Iyengar Hematology Oncology Medical Center Pa	Bayonne	New Jersey	07002-4654	Active, not recruiting
Summit Medical Group	Florham Park	New Jersey	07932-1049	Completed
New York Cancer and Blood Specialists	Shirley	New York	11967	Active, not recruiting
Suny Upstate Medical University	Syracuse	New York	13210-2306	Completed
North Shore Hematology Oncology Associates Eccc Bronx	The Bronx	New York	10469-5930	Completed
Clinical Research Alliance, Inc	Westbury	New York	11590-5119	Active, not recruiting
Levine Cancer Institute Wake Forest	Charlotte	North Carolina	28204-2990	Active, not recruiting
Oncology Hematology Care Clinical Trials, Llc	Cincinnati	Ohio	45245-1995	Completed
Va Northeast Ohio Healthcare System	Cleveland	Ohio	44106-1702	Completed
Toledo Clinic Cancer Center	Toledo	Ohio	43623-3536	Completed
Mainline Health Lankenau Institute For Medical Research	Wynnewood	Pennsylvania	19096	Completed
Cancer Care Associates of York	York	Pennsylvania	17403-5049	Active, not recruiting
Prairie Lakes Healthcare System	Watertown	South Dakota	57201-1548	Active, not recruiting
Texas Oncology Baylorcharles A Sammons Cancer Center	Dallas	Texas	75246-2003	Active, not recruiting
Md Anderson Cancer Center	Houston	Texas	77030-3907	Active, not recruiting
Northeast Texas Cancer and Research Institute	Tyler	Texas	75702-7522	Active, not recruiting
University of Washington	Seattle	Washington	98195	Active, not recruiting
Medical Oncology Associates	Spokane	Washington	99208-1129	Completed
Northwest Medical Specialties	Tacoma	Washington	98405	Completed

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 228 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05100862, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 21, 2026 · Synced May 8, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05100862 live on ClinicalTrials.gov.

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