A Study to Assess the Long-term Efficacy and Safety of AXS-12 (Reboxetine) in Subjects With Narcolepsy (ENCORE)
Public ClinicalTrials.gov record NCT05113745. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Study to Assess the Long-term Efficacy and Safety of AXS-12 in the Treatment of Cataplexy and Excessive Daytime Sleepiness in Subjects With Narcolepsy
Study identification
- NCT ID
- NCT05113745
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Axsome Therapeutics, Inc.
- Industry
- Enrollment
- 68 participants
Conditions and interventions
Conditions
Interventions
- AXS-12 (reboxetine) Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 15 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 19, 2021
- Primary completion
- Nov 14, 2024
- Completion
- Nov 14, 2024
- Last update posted
- Nov 12, 2025
2021 – 2024
United States locations
- U.S. sites
- 24
- U.S. states
- 12
- U.S. cities
- 23
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Clinical Research Site | Phoenix | Arizona | 85054 | — |
| Clinical Research Site | Boulder | Colorado | 80301 | — |
| Clinical Research Site | Colorado Springs | Colorado | 80918 | — |
| Clinical Research Site | Brandon | Florida | 33511 | — |
| Clinical Research Site | Clearwater | Florida | 33765 | — |
| Clinical Research Site | Doral | Florida | 33122 | — |
| Clinical Research Site | Miami Lakes | Florida | 33016 | — |
| Clinical Research Site | Winter Park | Florida | 32789 | — |
| Clinical Research Site | Atlanta | Georgia | 30315 | — |
| Clinical Research Site | Atlanta | Georgia | 30328 | — |
| Clinical Research Site | Stockbridge | Georgia | 30281 | — |
| Clinical Research Site | Chevy Chase | Maryland | 20815 | — |
| Clinical Research Site | Kalamazoo | Michigan | 49008 | — |
| Clinical Research Site | Novi | Michigan | 48377 | — |
| Clinical Research Site | Neptune City | New Jersey | 07753 | — |
| Clinical Research Site | Denver | North Carolina | 28037 | — |
| Clinical Research Site | Gastonia | North Carolina | 28054 | — |
| Clinical Research Site | Huntersville | North Carolina | 28078 | — |
| Clinical Research Site | Cincinnati | Ohio | 45245 | — |
| Clinical Research Site | Wyomissing | Pennsylvania | 19610 | — |
| Clinical Research Site | Charleston | South Carolina | 29425 | — |
| Clinical Research Site | Columbia | South Carolina | 29201 | — |
| Clinical Research Site | Austin | Texas | 78731 | — |
| Clinical Research Site | San Antonio | Texas | 78229 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05113745, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 12, 2025 · Synced May 18, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05113745 live on ClinicalTrials.gov.