A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid Malignancies

ClinicalTrials.gov ID: NCT05123482

Public ClinicalTrials.gov record NCT05123482. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 7, 2026, 2:37 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase I/IIa Multi-center, Open-label Master Protocol Dose Escalation and Expansion Study of AZD8205 as Monotherapy and in Combination With Anticancer Agents in Participants With Advanced Solid Tumors (BLUESTAR)

Study identification

NCT ID: NCT05123482
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1, Phase 2
Lead sponsor: AstraZeneca; Industry
Enrollment: 460 participants

Conditions and interventions

Conditions

Interventions

AZD8205 Drug
AZD8205 and AZD2936 (Rilvegostomig) Drug
AZD8205 and AZD5305 (saruparib) Drug
AZD8205 and AZD5305 (saruparib) and AZD2936 (rilvegostomig) Drug
AZD8205 in combination with AZD9574 Drug
AZD8205 in combination with AZD9574 plus rilvegostomig (AZD2936) Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Oct 17, 2021
Primary completion: Sep 28, 2027
Completion: Sep 28, 2027
Last update posted: Mar 22, 2026

2021 – 2027

United States locations

U.S. sites: 14
U.S. states: 10
U.S. cities: 14

Facility	City	State	ZIP	Site status
Research Site	Duarte	California	91010	Completed
Research Site	Irvine	California	92618	Completed
Research Site	Santa Monica	California	90404	Recruiting
Research Site	Santa Rosa	California	95403	Recruiting
Research Site	Shreveport	Louisiana	71103	Active, not recruiting
Research Site	Baltimore	Maryland	21231	Recruiting
Research Site	Boston	Massachusetts	02215	Recruiting
Research Site	St Louis	Missouri	63110	Recruiting
Research Site	Albuquerque	New Mexico	87109	Recruiting
Research Site	Commack	New York	11725	Recruiting
Research Site	New York	New York	10029	Withdrawn
Research Site	Charlotte	North Carolina	28204	Recruiting
Research Site	Pittsburgh	Pennsylvania	15213	Recruiting
Research Site	Houston	Texas	77030	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 51 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05123482, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Mar 22, 2026 · Synced May 7, 2026

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The complete protocol, eligibility criteria, and contact information for NCT05123482 live on ClinicalTrials.gov.

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