Randomized Trial Comparing Immediate vs. Deferred Surgery for Symptomatic ERM
Public ClinicalTrials.gov record NCT05145491. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Randomized Trial Comparing Immediate Versus Deferred Surgery for Symptomatic Epiretinal Membranes
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Vitrectomy to remove an epiretinal membrane (ERM) is one of the most common procedures performed by retinal surgeons. Patients who present with significant macular changes on optical coherence tomography (OCT) but relatively good vision are often advised to defer surgery until vision declines to 20/40 or worse. However, it is unknown if delaying surgery, which allows the foveal architecture to remain compromised and potentially to deteriorate, results in worse visual acuity outcomes than if surgery is performed earlier. In addition, there is a need to better understand predictors of outcomes when surgery is performed and predictors of progression when surgery is deferred. Finally, one of the most common presenting symptoms from an ERM is distortion or metamorphopsia. There are several objective measures of metamorphopsia but none have ever been employed to evaluate ERMs in a randomized clinical trial (RCT) and their usefulness is unknown. The purposes of this study are to better understand the optimal timing of surgery to produce the best visual result, to better understand predictors of outcomes in those who undergo surgery and predictors of progression in those whose are observed, and to better characterize and evaluate the usefulness of metamorphopsia and reading speed measures.
Study identification
- NCT ID
- NCT05145491
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 400 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 21, 2022
- Primary completion
- Dec 30, 2026
- Completion
- Dec 30, 2026
- Last update posted
- Jul 15, 2026
2022 – 2026
United States locations
- U.S. sites
- 47
- U.S. states
- 23
- U.S. cities
- 44
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Mayo Clinic Arizona | Scottsdale | Arizona | 85259 | Recruiting |
| Kent W. Small, MD, AMC | Glendale | California | 91203-1971 | Recruiting |
| Salehi Retina Institute Inc. | Huntington Beach | California | 92647-8693 | Recruiting |
| Loma Linda University | Loma Linda | California | 92354 | Recruiting |
| Retina Vitreous Associates, Northern California Retina Vitreous Assoc Medical Group, Inc. | Mountain View | California | 94040-4123 | Recruiting |
| East Bay Retina Consultants, Inc. | Oakland | California | 94609-3028 | Recruiting |
| Regents of the University of California, Davis, DBA University of California, Davis | Sacramento | California | 95817 | Recruiting |
| Macula Retina Vitreous Institute | Torrance | California | 90503 | Recruiting |
| Florida Retina Institute, James A. Staman, MD, PA- Jacksonville | Jacksonville | Florida | 32216 | Recruiting |
| Sarasota Retina Institute | Sarasota | Florida | 34239 | Recruiting |
| SEASHORE RETINA LLC DBA Retina Specialists of Tampa | Wesley Chapel | Florida | 33544 | Recruiting |
| Southeast Retina Center, P.C. | Augusta | Georgia | 30909 | Recruiting |
| Thomas Eye Group | Sandy Springs | Georgia | 30328 | Recruiting |
| Northwestern University | Chicago | Illinois | 60611 | Recruiting |
| Rush University Medical Center | Chicago | Illinois | 60612 | Recruiting |
| UIC - Department of Ophthalmology and Visual Sciences | Chicago | Illinois | 60612 | Recruiting |
| Illinois Retina Associates SC - Oak Park Site | Oak Park | Illinois | 60304 | Recruiting |
| Raj K. Maturi, M.D., P.C. | Indianapolis | Indiana | 46290 | Recruiting |
| Mid-America Retina Consultants, P.A. | Overland Park | Kansas | 66211 | Recruiting |
| University of Kansas Medical Center Research Institute, Inc. | Prairie Village | Kansas | 66208 | Recruiting |
| Joseph E. Humble and Raymond Haik PTRS DBA Eye Assoc of Northeast Louisiana | West Monroe | Louisiana | 71291-4452 | Recruiting |
| Elman Retina Group, P.A. | Baltimore | Maryland | 21237 | Recruiting |
| Johns Hopkins University | Baltimore | Maryland | 21287 | Recruiting |
| Valley Eye Physicians and Surgeons | Ayer | Massachusetts | 01432 | Recruiting |
| Joslin Diabetes Center | Boston | Massachusetts | 02215 | Recruiting |
| Retina Associates of Michigan | Grand Blanc | Michigan | 48439 | Recruiting |
| The Curators of the University of Missouri | Columbia | Missouri | 65201-5276 | Recruiting |
| Retina Research Institute, LLC | St Louis | Missouri | 63128-1729 | Recruiting |
| Retina-Vitreous Surgeons of Central NY, PC | Liverpool | New York | 13088 | Recruiting |
| Retina Associates of Western NY, P.C. | Rochester | New York | 14620-4655 | Recruiting |
| University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | 27517 | Recruiting |
| Retina Vitreous Center | Edmond | Oklahoma | 73013-9791 | Recruiting |
| Verum Research LLC | Eugene | Oregon | 97401 | Recruiting |
| Cascade Medical Research Institute, LLC | Springfield | Oregon | 97477 | Recruiting |
| Retina-Vitreous Consultants, Inc. | Monroeville | Pennsylvania | 15146 | Recruiting |
| The Trustees of the University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | Recruiting |
| Pittsburg Clinical Trial Consortium | Sewickley | Pennsylvania | 15143 | Recruiting |
| Hilton Head Retina Institute | Hilton Head Island | South Carolina | 29926 | Recruiting |
| Ophthalmology Ltd. | Sioux Falls | South Dakota | 57108 | Recruiting |
| Vanderbilt Eye Institute | Nashville | Tennessee | 37232 | Recruiting |
| Austin Research Center for Retina | Austin | Texas | 78705 | Recruiting |
| Retina Consultants of Texas | Bellaire | Texas | 77401 | Recruiting |
| Baylor College of Medicine, Baylor Eye Physicians and Surgeons | Houston | Texas | 77030 | Recruiting |
| Texas Retina Associates | Lubbock | Texas | 79424 | Recruiting |
| Retinal Consultants of San Antonio | San Antonio | Texas | 78240 | Recruiting |
| The Retina Group of Washington | Reston | Virginia | 20190 | Recruiting |
| Spokane Eye Clinical Research, PLLC | Spokane | Washington | 99204 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05145491, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 15, 2026 · Synced Sep 5, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05145491 live on ClinicalTrials.gov.