A Study of Alpelisib and Fulvestrant to Treat Endometrial Cancer
Public ClinicalTrials.gov record NCT05154487. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Phase 2 Study of Alpelisib and Fulvestrant for PIK3CA-mutated Estrogen Receptor (ER)-Positive Endometrioid Endometrial Cancers
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a 2 stage multi-center study designed to evaluate the efficacy of the combination of alpelisib and fulvestrant in patients with PIK3CA-mutated ER-positive endometrioid endometrial cancers by estimating the objective response rate (ORR). Treatment will continue until either unacceptable toxicity, progression of disease, or investigator/patient request for withdrawal.
Study identification
- NCT ID
- NCT05154487
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 51 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Female
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 11, 2024 (Actual)
- Primary completion
- May 1, 2028 (Estimated)
- Completion
- Nov 1, 2028 (Estimated)
- Last update posted
- Jul 30, 2026
2024 – 2028
United States locations
- U.S. sites
- 21
- U.S. states
- 12
- U.S. cities
- 19
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| City of Hope | Duarte | California | 91010 | — |
| Mount Sinai Medical Center | Miami Beach | Florida | 33140 | — |
| AdventHealth Gynecologic Oncology | Orlando | Florida | 32804 | — |
| Tampa General Hospital | Tampa | Florida | 33606 | — |
| Moffit Cancer Center at International Plaza | Tampa | Florida | 33607 | — |
| Moffitt Cancer Center | Tampa | Florida | 33612 | — |
| Moffit Cancer Center at Wesley Chapel | Wesley Chapel | Florida | 33544 | — |
| Endeavor Health | Evanston | Illinois | 60201 | — |
| Endeavor Health Clinical Operations, Glenbrook Hospital | Glenview | Illinois | 60026 | — |
| Endeavor Health Clinical Operations, Highland Park Hospital | Highland Park | Illinois | 60035 | — |
| Ascension St. Vincent | Indianapolis | Indiana | 46260 | — |
| Norton Cancer Institute | Louisville | Kentucky | 40241 | — |
| Johns Hopkins Medicine | Baltimore | Maryland | 21287 | — |
| Northwell Health Cancer Institute | Lake Success | New York | 11042 | — |
| QCC- Northwell Health Physicians Partners Medical | Rego Park | New York | 11374 | — |
| Kettering Health Cancer Center | Kettering | Ohio | 45429 | — |
| Oklahoma Cancer Specialists and Research Institute, LLC | Tulsa | Oklahoma | 74146 | — |
| Legacy Good Samaritan Medical Center | Portland | Oregon | 97210 | — |
| Legacy Meridian Park Medical Center | Tualatin | Oregon | 97062 | — |
| Legacy Salmon Creek Medical Center | Vancouver | Washington | 98686 | — |
| University of Wisconsin Clinical Science Center | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05154487, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 30, 2026 · Synced Oct 18, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05154487 live on ClinicalTrials.gov.