Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS) (REMODEL-2)
Public ClinicalTrials.gov record NCT05156281. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-blind, Double-dummy, Parallel-group Study, Comparing the Efficacy and Safety of Remibrutinib Versus Teriflunomide in Participants With Relapsing Multiple Sclerosis, Followed by Extended Treatment With Open-label Remibrutinib
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
To compare the efficacy and safety of remibrutinib versus teriflunomide in patients with relapsing multiple sclerosis (RMS)
Study identification
- NCT ID
- NCT05156281
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,007 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 55 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 13, 2021 (Actual)
- Primary completion
- Jul 22, 2026 (Actual)
- Completion
- Oct 30, 2030 (Estimated)
- Last update posted
- Aug 18, 2026
2021 – 2030
United States locations
- U.S. sites
- 50
- U.S. states
- 23
- U.S. cities
- 45
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Ctr for Neurology and Spine | Phoenix | Arizona | 85018 | — |
| Vladimir Royter MD APMC | Hanford | California | 93230 | — |
| VA Greater LA Healthcare System | Los Angeles | California | 90073 | — |
| Regina Berkovich MD PhD Inc | West Hollywood | California | 90048 | — |
| CU Anschutz Med Campus | Aurora | Colorado | 80045 | — |
| Colorado Neurological Research PC | Denver | Colorado | 80210 | — |
| New England Institute for Clinical Research | Stamford | Connecticut | 06905 | — |
| Georgetown University Hospital Research | Washington D.C. | District of Columbia | 20007 | — |
| Georgetown University Hospital | Washington D.C. | District of Columbia | 20007 | — |
| Nova Clinical Research LLC | Bradenton | Florida | 34209 | — |
| University of Florida | Gainesville | Florida | 32610 | — |
| Memorial Healthcare System | Hollywood | Florida | 33021 | — |
| Neurology Associates PA | Maitland | Florida | 32751 | — |
| Gables Neurology | Miami | Florida | 33133 | — |
| UM Department Of Neurology | Miami | Florida | 33136 | — |
| Aqualane Clinical Research | Naples | Florida | 34105 | — |
| Advent Health Orlando | Orlando | Florida | 32803 | — |
| Humanity Clinical Research | Pembroke Pines | Florida | 33024 | — |
| Emerald Coast Neurology | Pensacola | Florida | 32514 | — |
| Brain and Spine Institute | Port Orange | Florida | 32127 | — |
| Vero Beach Neurology | Vero Beach | Florida | 32960 | — |
| Conquest Research | Winter Park | Florida | 32789 | — |
| Methodist Neuroscience Institute | Merrillville | Indiana | 46410 | — |
| University of Kansas Hospital | Kansas City | Kansas | 66160 | — |
| Baptist Physicians Lexington | Nicholasville | Kentucky | 40356 | — |
| Ochsner Clinic Foundation | New Orleans | Louisiana | 70121 | — |
| Clinre Comprehensive Neurology | Frederick | Maryland | 21702 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| Kansas City VA Medical Center | Kansas City | Missouri | 64128 | — |
| South Shore Neurologic Associates | Patchogue | New York | 11772 | — |
| University Of NC At Chapel Hill | Chapel Hill | North Carolina | 27599 9500 | — |
| Piedmont HealthCare | Charlotte | North Carolina | 28210 | — |
| The Boster Ctr for MS | Columbus | Ohio | 43235 | — |
| Neurology Diagnostics Inc | Dayton | Ohio | 45408 | — |
| Penn State Hershey Medical Center | Hershey | Pennsylvania | 17033 | — |
| Premier Neurology | Greenville | South Carolina | 29605 | — |
| Metrolina Neurological Associates PA | Old Point Station | South Carolina | 29707 | — |
| Sibyl Wray MD Neurology PC | Knoxville | Tennessee | 37922 | — |
| Neurology Consultants Of Dallas PA | Dallas | Texas | 75231 | — |
| Med Research Inc | El Paso | Texas | 79935 | — |
| Lone Star Neurology | Frisco | Texas | 75035 | — |
| UT Health MARC Medical Arts and Research Center | San Antonio | Texas | 78229 | — |
| Lonestar Neurology of San Antonio | San Antonio | Texas | 78258 | — |
| Texas Institute for Neurological Disorders | Sherman | Texas | 75092 | — |
| Baylor Scott and White | Temple | Texas | 76508 | — |
| Virginia Mason Medical Centre | Seattle | Washington | 98101 | — |
| University of Washington MS Clinic | Seattle | Washington | 98133 | — |
| Elligo Health Research | Crab Orchard | West Virginia | 25827 | — |
| Ascension St Francis Center | Milwaukee | Wisconsin | 53215 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 173 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05156281, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 18, 2026 · Synced Oct 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05156281 live on ClinicalTrials.gov.