Abemaciclib (LY2835219) Plus Fulvestrant Compared to Placebo Plus Fulvestrant in Previously Treated Breast Cancer
Public ClinicalTrials.gov record NCT05169567. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
postMONARCH: A Randomized, Double Blind, Placebo-Controlled, Phase 3 Study to Compare the Efficacy of Abemaciclib Plus Fulvestrant to Placebo Plus Fulvestrant in Participants With HR+, HER2-, Advanced or Metastatic Breast Cancer Following Progression on a CDK4 & 6 Inhibitor and Endocrine Therapy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will evaluate the effect of adding abemaciclib to fulvestrant for the treatment of hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) breast cancer that progressed or recurred after previous treatment with a type of drug known as a CDK4/6 inhibitor and endocrine therapy. Participation could last up to 5 years, depending on how you and your tumor respond.
Study identification
- NCT ID
- NCT05169567
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 368 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 11, 2022 (Actual)
- Primary completion
- Feb 8, 2024 (Actual)
- Completion
- Dec 2027 (Estimated)
- Last update posted
- Oct 6, 2026
2022 – 2027
United States locations
- U.S. sites
- 60
- U.S. states
- 21
- U.S. cities
- 55
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| St. Joseph's Hospital and Medical Center | Phoenix | Arizona | 85004 | — |
| Highlands Oncology Group | Springdale | Arkansas | 72762 | — |
| Providence Medical Foundation | Fullerton | California | 92835 | — |
| Cancer and Blood Specialty Clinic | Los Alamitos | California | 90720 | — |
| TRIO-US (Translational Research in Oncology-US) | Los Angeles | California | 90024 | — |
| Keck School of Medicine of USC | Los Angeles | California | 90033 | — |
| UCLA Hematology/Oncology - Parkside | Santa Monica | California | 90404 | — |
| Olive View-UCLA Medical Center | Sylmar | California | 91342 | — |
| Torrance Memorial Physician Network / Cancer Care | Torrance | California | 90505 | — |
| PIH Health Hematology Medical Oncology | Whittier | California | 90602 | — |
| Rocky Mountain Cancer Center - Hale Parkway | Denver | Colorado | 80220 | — |
| Florida Cancer Specialists SOUTH/Sarah Cannon Research Institute/SCRI | Fort Myers | Florida | 33901-8101 | — |
| Millennium Oncology Research Clinic | Hollywood | Florida | 33024 | — |
| University of Miami Hospital and Clinics, Sylvester Cancer Center | Miami | Florida | 33136 | — |
| Woodlands Medical Specialists, PA | Pensacola | Florida | 32503 | — |
| Florida Cancer Specialists SOUTH/Sarah Cannon Research Institute/SCRI | Sarasota | Florida | 34232 | — |
| Florida Cancer Specialists EAST/Sarah Cannon Research Institute/SCRI | West Palm Beach | Florida | 33401 | — |
| Winship Cancer Institute, Emory University | Atlanta | Georgia | 30322 | — |
| Northeast Georgia Medical Center | Gainesville | Georgia | 30501 | — |
| Central Georgia Cancer Care | Macon | Georgia | 31201 | — |
| Kapiolani Medical Center for Women and Children | Honolulu | Hawaii | 96826 | — |
| Ingalls Memorial Hospital | Harvey | Illinois | 60426 | — |
| Hematology Oncology Clinic- Baton Rouge/Sarah Cannon Research Institute/SCRI | Baton Rouge | Louisiana | 70809 | — |
| Clinical Trials of SWLA | Lake Charles | Louisiana | 70601 | — |
| Central Maine Medical Center | Lewiston | Maine | 04240 | — |
| Mfsmc-Hjwci | Baltimore | Maryland | 21237 | — |
| Maryland Oncology Hematology, P.A. - Clinton | Clinton | Maryland | 20735 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Dana Farber Cancer Institute | Boston | Massachusetts | 02215 | — |
| MGH Northshore Cancer Center | Danvers | Massachusetts | 01923 | — |
| Southcoast Centers for Cancer Care | Fairhaven | Massachusetts | 02719 | — |
| Dana-Farber Cancer Institute - Foxborough | Foxborough | Massachusetts | 02035 | — |
| Dana Farber Cancer Center Merrimack Valley | Methuen | Massachusetts | 01844 | — |
| Dana Farber Cancer Institute | Milford | Massachusetts | 01757 | — |
| Mass General Cancer Center | Newton | Massachusetts | 02462 | — |
| Dana Farber Cancer Institute | South Weymouth | Massachusetts | 02190 | — |
| Reliant Medical Group | Worcester | Massachusetts | 01606 | — |
| St. Vincent Frontier Cancer Center | Billings | Montana | 59102 | — |
| Dana Farber Cancer Center Londonderry | Londonderry | New Hampshire | 03053 | — |
| University of New Mexico Comprehensive Cancer Center | Albuquerque | New Mexico | 87106 | — |
| Lifespan Cancer Institute | Providence | Rhode Island | 02906 | — |
| Tennessee Oncology-Chattanooga /Sarah Cannon Research Institute/SCRI | Chattanooga | Tennessee | 37404 | — |
| Sarah Cannon Research Institute/SCRI | Nashville | Tennessee | 37203 | — |
| Tennessee Oncology-Nashville/Sarah Cannon Research Institute/SCRI | Nashville | Tennessee | 37203 | — |
| Texas Oncology - Bedford | Bedford | Texas | 76022 | — |
| Texas Oncology - Denton | Denton | Texas | 76201 | — |
| Texas Oncology, P.A. | El Paso | Texas | 79902 | — |
| University of Texas MD Anderson Cancer Center | Houston | Texas | 77030-4009 | — |
| Texas Oncology - McKinney | McKinney | Texas | 75071 | — |
| Woodlands Medical Specialists, PA | McKinney | Texas | 75071 | — |
| Woodlands Medical Specialists, PA | Mesquite | Texas | 75150 | — |
| Texas Oncology - Plano East | Plano | Texas | 75075-7787 | — |
| Texas Oncology-Plano West | Plano | Texas | 75093 | — |
| Mays Cancer Center | San Antonio | Texas | 78229 | — |
| US Oncology | The Woodlands | Texas | 77380 | — |
| Texas Oncology - Tyler Cancer Center | Tyler | Texas | 75702 | — |
| Intermountain Medical Center | Murray | Utah | 84107 | — |
| Intermountain Healthcare - St. George | St. George | Utah | 84790 | — |
| The University of Vermont Medical Center Inc. | Burlington | Vermont | 05401 | — |
| Shenandoah Oncology, P.C. | Winchester | Virginia | 22601 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 78 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05169567, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 6, 2026 · Synced Oct 19, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05169567 live on ClinicalTrials.gov.