ClinicalTrials.gov record
ALLIANCE: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve
ClinicalTrials.gov ID: NCT05172960
Public ClinicalTrials.gov record NCT05172960. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced Apr 22, 2026, 6:13 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Safety and Effectiveness of Balloon-Expandable Bioprosthetic SAPIEN X4 Transcatheter Heart Valve
Study identification
- NCT ID
- NCT05172960
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Not applicable
- Lead sponsor
- Edwards Lifesciences
- Industry
- Enrollment
- 915 participants
Conditions and interventions
Conditions
Interventions
- SAPIEN X4 THV Device
Device
Eligibility (public fields only)
- Age range
- Not listed
- Sex
- All
- Healthy volunteers
- Not listed
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 19, 2022
- Primary completion
- Jul 21, 2025
- Completion
- Nov 30, 2034
- Last update posted
- Aug 13, 2025
2022 – 2034
United States locations
- U.S. sites
- 58
- U.S. states
- 26
- U.S. cities
- 47
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Scripps Memorial Hospital La Jolla | La Jolla | California | 92037 | — |
| Kaiser Los Angeles | Los Angeles | California | 90027 | — |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| Hoag Memorial Hospital Presbyterian | Newport Beach | California | 92663 | — |
| UC Davis Medical Center Sacramento | Sacramento | California | 95817 | — |
| Bay Area Structural Heart at Sutter Health | San Francisco | California | 94109 | — |
| Kaiser San Francisco Medical Center | San Francisco | California | 94115 | — |
| Stanford University | Stanford | California | 94305 | — |
| UC Health Northern Colorado (Medical Center of the Rockies) | Loveland | Colorado | 80538 | — |
| Hartford Hospital | Hartford | Connecticut | 06102 | — |
| Naples Community Hospital Healthcare System | North Naples | Florida | 34102 | — |
| Piedmont Heart Institute | Atlanta | Georgia | 30309 | — |
| Emory University Atlanta | Atlanta | Georgia | 30322 | — |
| Rush University Medical Center Chicago | Chicago | Illinois | 60612 | — |
| Alexian Brothers Hospital Network | Elk Grove Village | Illinois | 60007 | — |
| NorthShore University HealthSystem Research Institute Evanston | Evanston | Illinois | 60201 | — |
| Northwestern University Chicago | Evanston | Illinois | 60611 | — |
| Silver Cross Hospital | New Lenox | Illinois | 60541 | — |
| St. Vincent Medical Group, Inc./ St. Vincent Heart Center of Indiana, LLC | Carmel | Indiana | 46290 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| Cardiovascular Research Institute of Kansas | Wichita | Kansas | 67226 | — |
| Medstar Union Memorial Hospital | Baltimore | Maryland | 21218 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Mayo Clinic Rochester | Rochester | Minnesota | 55905 | — |
| CentraCare Heart and Vascular Center | Saint Cloud | Minnesota | 56303 | — |
| Saint Luke's Hospital | Kansas City | Missouri | 64111 | — |
| Washington University - Barnes-Jewish Hospital Saint Louis | St Louis | Missouri | 63110 | — |
| St. Patrick Hospital | Missoula | Montana | 59802 | — |
| Dartmouth-Hitchcock Medical Center, Hanover | Lebanon | New Hampshire | 03756 | — |
| Atlantic Health System Morristown | Morristown | New Jersey | 07960 | — |
| Rutgers Robert Wood Johnson Medical School | New Brunswick | New Jersey | 08901 | — |
| The Valley Hospital | Ridgewood | New Jersey | 07450 | — |
| University at Buffalo - Kaleida Health | Buffalo | New York | 14203 | — |
| Cornell Medical Center | New York | New York | 10021 | — |
| Columbia University Medical Center/NYPH | New York | New York | 10032 | — |
| Montefiore Medical Center | New York | New York | 10458 | — |
| Carolinas Health System | Charlotte | North Carolina | 28203 | — |
| Novant Health and Heart Vascular Institute | Charlotte | North Carolina | 28204 | — |
| The Christ Hospital | Cincinnati | Ohio | 45219 | — |
| The Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| Oklahoma Cardiovascular Research Group Oklahoma City | Oklahoma City | Oklahoma | 73120 | — |
| Oklahoma Heart Institute | Tulsa | Oklahoma | 74104 | — |
| Kaiser Portland | Clackamas | Oregon | 97015 | — |
| Providence Heart & Vascular Institute Portland | Portland | Oregon | 97225 | — |
| Pinnacle Health Harrisburg | Harrisburg | Pennsylvania | 17101 | — |
| Allegheny General Hospital | Pittsburgh | Pennsylvania | 15212 | — |
| Methodist Le Bonheur Healthcare | Germantown | Tennessee | 38138 | — |
| Centennial Medical Center | Nashville | Tennessee | 37203 | — |
| Saint Thomas Health | Nashville | Tennessee | 37205 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | — |
| Baylor Heart and Vascular Hospital | Dallas | Texas | 75226 | — |
| Medical City Dallas Hospital | Dallas | Texas | 75230 | — |
| HCA Houston Healthcare Medical Center | Houston | Texas | 77004 | — |
| University of Texas Memorial Hermann | Houston | Texas | 77030 | — |
| The Heart Hospital Baylor Plano | Plano | Texas | 75093 | — |
| Sentara Norfolk General Hospital | Norfolk | Virginia | 23507 | — |
| University of Washington Seattle | Seattle | Washington | 98195 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 7 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05172960, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 13, 2025 · Synced Apr 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05172960 live on ClinicalTrials.gov.