ALLIANCE AVIV: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves
Public ClinicalTrials.gov record NCT05172973. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Safety and Effectiveness of Balloon-Expandable Bioprosthetic SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves
Study identification
- NCT ID
- NCT05172973
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Not applicable
- Lead sponsor
- Edwards Lifesciences
- Industry
- Enrollment
- 200 participants
Conditions and interventions
Conditions
Interventions
- SAPIEN X4 THV Device
Device
Eligibility (public fields only)
- Age range
- Not listed
- Sex
- All
- Healthy volunteers
- Not listed
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 21, 2023
- Primary completion
- Nov 30, 2026
- Completion
- Jan 31, 2036
- Last update posted
- Dec 21, 2025
2023 – 2036
United States locations
- U.S. sites
- 32
- U.S. states
- 19
- U.S. cities
- 28
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Hoag Memorial Hospital Presbyterian | Newport Beach | California | 92663 | Recruiting |
| Bay Area Structural Heart at Sutter Health | San Francisco | California | 94105 | Recruiting |
| Kaiser San Francisco | San Francisco | California | 94115 | Recruiting |
| Stanford University Medical Center | Stanford | California | 94305 | Recruiting |
| UC Health Medical Center of the Rockies | Loveland | Colorado | 80538 | Recruiting |
| Naples Community Hospital Healthcare System | Naples | Florida | 34102 | Recruiting |
| Emory University Atlanta | Atlanta | Georgia | 30308 | Recruiting |
| Piedmont Heart Institute | Atlanta | Georgia | 30309 | Recruiting |
| Northwestern University Chicago | Evanston | Illinois | 60208 | Recruiting |
| Alexian Brothers Hospital Network | Lisle | Illinois | 60532 | Recruiting |
| Cardiovascular Research Institute of Kansas | Wichita | Kansas | 67226 | Recruiting |
| MedStar Union Memorial Hospital | Baltimore | Maryland | 21218 | Recruiting |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | Recruiting |
| Henry Ford Hospital Detroit | Detroit | Michigan | 48202 | Recruiting |
| Mayo Clinic | Rochester | Minnesota | 55905 | Recruiting |
| Atlantic Health System Morristown | Morristown | New Jersey | 07960 | Recruiting |
| Robert Wood Johnson University Hospital | New Brunswick | New Jersey | 08901 | Recruiting |
| The Valley Hospital | Ridgewood | New Jersey | 07450 | Recruiting |
| University of Buffalo | Buffalo | New York | 14203 | Recruiting |
| Cornelll University New York | New York | New York | 10021 | Recruiting |
| Columbia University Medical Center / NYPH | New York | New York | 10032 | Recruiting |
| Rochester General Hospital | Rochester | New York | 14621 | Recruiting |
| Carolinas Health System | Charlotte | North Carolina | 28204 | Recruiting |
| Novant Health and Vascular Institute | Charlotte | North Carolina | 28204 | Recruiting |
| The Christ Hospital | Cincinnati | Ohio | 45219 | Recruiting |
| The Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | Recruiting |
| Oklahoma Heart Institute | Tulsa | Oklahoma | 74104 | Recruiting |
| Allegheny General Hospital | Pittsburgh | Pennsylvania | 15212 | Recruiting |
| Saint Thomas Health | Nashville | Tennessee | 37205 | Recruiting |
| University of Texas Memorial Hermann | Houston | Texas | 77030 | Recruiting |
| The Heart Hospital Baylor Plano | Plano | Texas | 75093 | Recruiting |
| University of Washington Seattle | Seattle | Washington | 98195 | Withdrawn |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 3 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05172973, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 21, 2025 · Synced Apr 22, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05172973 live on ClinicalTrials.gov.