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Recruiting Phase 1 Interventional

Study of Zanzalintinib in Combination With Immuno-Oncology Agents in Participants With Solid Tumors

ClinicalTrials.gov ID: NCT05176483

Public ClinicalTrials.gov record NCT05176483. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 5, 2026, 11:07 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Dose-Escalation and Expansion Study of the Safety and Efficacy of XL092 in Combination With Immuno-Oncology Agents in Subjects With Unresectable Advanced or Metastatic Solid Tumors

Study identification

NCT ID
NCT05176483
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 1
Lead sponsor
Exelixis
Industry
Enrollment
1,314 participants

Conditions and interventions

Interventions

  • Ipilimumab Drug
  • Nivolumab Drug
  • Nivolumab + Relatlimab Drug
  • Zanzalintinib Drug

Drug

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Dec 13, 2021
Primary completion
Jun 27, 2030
Completion
Jun 27, 2030
Last update posted
Mar 11, 2026

2021 – 2030

United States locations

U.S. sites
46
U.S. states
26
U.S. cities
41
Facility City State ZIP Site status
Exelixis Clinical Site #67 Phoenix Arizona 85054 Recruiting
Exelixis Clinical Site #1 Tucson Arizona 85711 Recruiting
Exelixis Clinical Site #123 Palo Alto California 94304 Recruiting
Exelixis Clinical Site #59 Santa Barbara California 93463 Recruiting
Exelixis Clinical Site #87 Littleton Colorado 80124 Recruiting
Exelixis Clinical Site #62 New Haven Connecticut 06510 Recruiting
Exelixis Clinical Site #49 Newark Delaware 19713 Active, not recruiting
Exelixis Clinical Site #48 Celebration Florida 34747 Recruiting
Exelixis Clinical Site #11 Gainesville Florida 32610 Recruiting
Exelixis Clinical Site #78 Jacksonville Florida 32224 Recruiting
Exelixis Clinical Site #47 Miami Florida 33136 Recruiting
Exelixis Clinical Site #61 Plantation Florida 33322 Recruiting
Exelixis Clinical Site #8 Tampa Florida 33612 Recruiting
Exelixis Clinical Site #26 Chicago Illinois 60612 Recruiting
Exelixis Clinical Site #4 Indianapolis Indiana 46250 Recruiting
Exelixis Clinical Site #122 Louisville Kentucky 40202 Recruiting
Exelixis Clinical Site #14 Baltimore Maryland 21201 Recruiting
Exelixis Clinical Site #7 Boston Massachusetts 02215 Recruiting
Exelixis Clinical Site #65 Detroit Michigan 48201 Recruiting
Exelixis Clinical Site #13 Detroit Michigan 48202 Recruiting
Exelixis Clinical Site #68 Rochester Minnesota 55905 Recruiting
Exelixis Clinical Site #2 Omaha Nebraska 68130 Recruiting
Exelixis Clinical Site #5 Omaha Nebraska 68130 Active, not recruiting
Exelixis Clinical Site #55 Las Vegas Nevada 89052 Recruiting
Exelixis Clinical Site #88 East Brunswick New Jersey 08816 Recruiting
Exelixis Clinical Site #105 Hackensack New Jersey 07601 Recruiting
Exelixis Clinical Site #60 New York New York 10032 Recruiting
Exelixis Clinical Site #6 New York New York 10065 Recruiting
Exelixis Clinical Site #76 Syracuse New York 13210 Recruiting
Exelixis Clinical Site #12 Durham North Carolina 27710 Recruiting
Exelixis Clinical Site #10 Cleveland Ohio 44106 Recruiting
Exelixis Clinical Site #51 Portland Oregon 97239 Recruiting
Exelixis Clinical Site #104 Hershey Pennsylvania 17033 Recruiting
Exelixis Clinical Site #98 Philadelphia Pennsylvania 19104 Recruiting
Exelixis Clinical Site #32 Pittsburgh Pennsylvania 15212 Recruiting
Exelixis Clinical Site #24 Pittsburgh Pennsylvania 15232 Recruiting
Exelixis Clinical Site #9 Myrtle Beach South Carolina 29572 Recruiting
Exelixis Clinical Site #3 Nashville Tennessee 37203 Recruiting
Exelixis Clinical Site #46 Austin Texas 78705 Recruiting
Exelixis Clinical Site #111 Dallas Texas 75246 Recruiting
Exelixis Clinical Site #89 Dallas Texas 75246 Recruiting
Exelixis Clinical Site #73 Irving Texas 75063 Recruiting
Exelixis Clinical Site #50 Plano Texas 75075 Recruiting
Exelixis Clinical Site #70 Tyler Texas 75601 Recruiting
Exelixis Clinical Site #66 Charlottesville Virginia 22903 Recruiting
Exelixis Clinical Site #33 Milwaukee Wisconsin 53226 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 76 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT05176483, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Mar 11, 2026 · Synced May 5, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05176483 live on ClinicalTrials.gov.

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