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Recruiting Phase 2 Interventional

Testing the Addition of an Anti-Cancer Drug, TRC102, to the Usual Chemotherapy Treatment (Pemetrexed, Cisplatin or Carboplatin) During Radiation Therapy for Stage III Non-Squamous Non-Small Cell Lung Cancer

ClinicalTrials.gov ID: NCT05198830

Public ClinicalTrials.gov record NCT05198830. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 8, 2026, 5:06 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 2 Randomized Study of the BER Inhibitor TRC102 in Combination With Standard Pemetrexed-Platinum-Radiation in Stage III Non-Squamous Non-Small Cell Lung Cancer

Study identification

NCT ID
NCT05198830
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 2
Lead sponsor
National Cancer Institute (NCI)
NIH
Enrollment
42 participants

Conditions and interventions

Interventions

  • Carboplatin Drug
  • Cisplatin Drug
  • Computed Tomography Procedure
  • Durvalumab Biological
  • FDG-Positron Emission Tomography Procedure
  • Magnetic Resonance Imaging Procedure
  • Methoxyamine Drug
  • Pemetrexed Drug
  • Radiation Therapy Radiation

Drug · Procedure · Biological + 1 more

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Dec 14, 2022
Primary completion
Jun 29, 2027
Completion
Jun 29, 2027
Last update posted
Apr 27, 2026

2022 – 2027

United States locations

U.S. sites
34
U.S. states
10
U.S. cities
30
Facility City State ZIP Site status
Keck Medicine of USC Buena Park Buena Park California 90621 Suspended
City of Hope Comprehensive Cancer Center Duarte California 91010 Recruiting
City of Hope at Irvine Lennar Irvine California 92618 Recruiting
City of Hope Antelope Valley Lancaster California 93534 Recruiting
Los Angeles General Medical Center Los Angeles California 90033 Recruiting
USC / Norris Comprehensive Cancer Center Los Angeles California 90033 Recruiting
USC Norris Oncology/Hematology-Newport Beach Newport Beach California 92663 Recruiting
University of California Davis Comprehensive Cancer Center Sacramento California 95817 Recruiting
City of Hope South Pasadena South Pasadena California 91030 Recruiting
City of Hope Upland Upland California 91786 Recruiting
UM Sylvester Comprehensive Cancer Center at Coral Gables Coral Gables Florida 33146 Recruiting
UM Sylvester Comprehensive Cancer Center at Deerfield Beach Deerfield Beach Florida 33442 Recruiting
UF Health Cancer Institute - Gainesville Gainesville Florida 32610 Recruiting
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami Florida 33136 Recruiting
UM Sylvester Comprehensive Cancer Center at Kendall Miami Florida 33176 Recruiting
UM Sylvester Comprehensive Cancer Center at Plantation Plantation Florida 33324 Recruiting
University of Chicago Comprehensive Cancer Center Chicago Illinois 60637 Recruiting
UC Comprehensive Cancer Center at Silver Cross New Lenox Illinois 60451 Recruiting
University of Chicago Medicine-Orland Park Orland Park Illinois 60462 Recruiting
UChicago Medicine Northwest Indiana Crown Point Indiana 46307 Recruiting
Jersey City Medical Center Jersey City New Jersey 07302 Recruiting
Saint Barnabas Medical Center Livingston New Jersey 07039 Recruiting
Monmouth Medical Center Long Branch New Jersey 07740 Recruiting
Rutgers Cancer Institute of New Jersey New Brunswick New Jersey 08903 Recruiting
Newark Beth Israel Medical Center Newark New Jersey 07112 Recruiting
Robert Wood Johnson University Hospital Somerset Somerville New Jersey 08876 Recruiting
Community Medical Center Toms River New Jersey 08755 Recruiting
Montefiore Medical Center-Einstein Campus The Bronx New York 10461 Active, not recruiting
Montefiore Medical Center - Moses Campus The Bronx New York 10467 Active, not recruiting
Wake Forest University Health Sciences Winston-Salem North Carolina 27157 Recruiting
Case Western Reserve University Cleveland Ohio 44106 Recruiting
MetroHealth Medical Center Cleveland Ohio 44109 Recruiting
University of Pittsburgh Cancer Institute (UPCI) Pittsburgh Pennsylvania 15232 Recruiting
University of Texas Medical Branch Galveston Texas 77555-0565 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT05198830, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Apr 27, 2026 · Synced May 8, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05198830 live on ClinicalTrials.gov.

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