Ribociclib vs. Palbociclib in Patients With Advanced Breast Cancer Within the HER2-Enriched Intrinsic Subtype
Public ClinicalTrials.gov record NCT05207709. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III, Multicenter, Open-label Study of Ribociclib vs. Palbociclib in Patients With Advanced Hormone Receptor-positive/HER2-negative/HER2-Enriched Breast Cancer - HARMONIA Trial
Study identification
- NCT ID
- NCT05207709
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- SOLTI Breast Cancer Research Group
- Other
- Enrollment
- 456 participants
Conditions and interventions
Conditions
Interventions
- Paclitaxel +/- Tislelizumab Drug
- Palbociclib + Letrozole OR Fulvestrant Drug
- Ribociclib + Letrozole OR Fulvestrant Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 27, 2022
- Primary completion
- Feb 28, 2026
- Completion
- Feb 28, 2027
- Last update posted
- Apr 28, 2025
2022 – 2027
United States locations
- U.S. sites
- 26
- U.S. states
- 16
- U.S. cities
- 25
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Morton Plant Hospital | Clearwater | Florida | 33756 | — |
| University of Miami | Coral Gables | Florida | 33124 | — |
| Memorial Regional Hospital | Hollywood | Florida | 33021 | — |
| Mount Sinai Florida | Miami | Florida | 33140 | — |
| Northwestern | Chicago | Illinois | 60611 | — |
| Carle Cancer Center | Urbana | Illinois | 61801 | — |
| University of Kentucky, Markey Cancer Center | Lexington | Kentucky | 40536 | — |
| Sinai of Baltimore | Baltimore | Maryland | 21215 | — |
| Dana Faber Cancer Institute | Boston | Massachusetts | 02215 | — |
| Baptist Memorial Health Care | Oxford | Mississippi | 38655 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198 | — |
| Nevada Cancer Research Foundation | Las Vegas | Nevada | 89121 | — |
| NHOH | Londonderry | New Hampshire | 03053 | — |
| Nothwell Health | New York | New York | 11042-1069 | — |
| Montefiore | The Bronx | New York | 10467 | — |
| University of North Carolina Lineberger | Chapel Hill | North Carolina | 27514 | — |
| Novant Health Care | Winston-Salem | North Carolina | 27103 | — |
| Ohio State University Comprehensive Cancer Center | Columbus | Ohio | 43210 | — |
| Dayton Clinical Oncology | Kettering | Ohio | 45429 | — |
| Legacy Good Samaritan Hospital and Medical Cente | Portland | Oregon | 97210 | — |
| Providence Portland Medical Center | Portland | Oregon | 97225 | — |
| The Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Upstate Carolina Medical Center | Spartanburg | South Carolina | 29302 | — |
| Edwards Comprehensive Cancer Center | Huntington | Virginia | 25701 | — |
| Bon Secours Memorial Regional Medical Center | Mechanicsville | Virginia | 231136 | — |
| Unv. Wisconsin | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 45 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05207709, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 28, 2025 · Synced May 8, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05207709 live on ClinicalTrials.gov.