Hyperhydration in Children With Shiga Toxin-Producing E. Coli Infection

ClinicalTrials.gov ID: NCT05219110

Public ClinicalTrials.gov record NCT05219110. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Oct 16, 2026, 11:41 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Hyperhydration to Improve Kidney Outcomes in Children With Shiga Toxin-Producing E. Coli Infection: A Multinational Embedded Cluster Crossover Randomized Trial

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The objective of this study is to determine if early high volume intravenous fluid administration (hyperhydration) may be effective in mitigating or preventing complications of shiga toxin-producing E. coli (STEC) infection in children and adolescents when compared with traditional approaches (conservative fluid management).

Study identification

NCT ID: NCT05219110
Recruitment status: Recruiting
Study type: Interventional
Phase: Not applicable
Lead sponsor: University of Calgary; Other
Enrollment: 1,040 participants

Conditions and interventions

Conditions

Interventions

Other

Eligibility (public fields only)

Age range: 9 Months to 21 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Sep 29, 2022 (Actual)
Primary completion: Aug 31, 2027 (Estimated)
Completion: Aug 31, 2028 (Estimated)
Last update posted: May 18, 2026

2022 – 2028

United States locations

U.S. sites: 22
U.S. states: 18
U.S. cities: 22

Facility	City	State	ZIP	Site status
University of Alabama at Birmingham	Birmingham	Alabama	35294	Recruiting
Arkansas Children's Hospital	Little Rock	Arkansas	72202	Recruiting
University of California, San Diego	La Jolla	California	92093	Recruiting
University of California, Davis	Sacramento	California	95817	Recruiting
University of Colorado Denver	Denver	Colorado	80045	Recruiting
Children's Research Institute	Washington D.C.	District of Columbia	20010	Recruiting
Emory University	Atlanta	Georgia	30322	Recruiting
Indiana University Children's Hospital	Indianapolis	Indiana	47401	Recruiting
University of Kentucky	Lexington	Kentucky	40526	Recruiting
Norton Children's Hospital	Louisville	Kentucky	40202	Recruiting
Children's Minnesota Hospital	Minneapolis	Minnesota	55404	Recruiting
Washington University	St Louis	Missouri	63110	Recruiting
Children's Hospital Medical Center	Cincinnati	Ohio	45229-3039	Recruiting
University Hospitals Rainbow Babies & Children's Hospital	Cleveland	Ohio	44106	Recruiting
Nationwide Children's Hospital	Columbus	Ohio	43205	Recruiting
University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	73104	Recruiting
Oregon Health & Science University	Portland	Oregon	97239	Recruiting
Medical University of South Carolina	Charleston	South Carolina	29425	Recruiting
Vanderbilt Children's Hospital	Nashville	Tennessee	43205	Recruiting
Baylor College of Medicine	Houston	Texas	77030	Recruiting
University of Utah	Salt Lake City	Utah	84112	Recruiting
Seattle Children's Hospital	Seattle	Washington	98105	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 4 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05219110, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 18, 2026 · Synced Oct 16, 2026

Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT05219110 live on ClinicalTrials.gov.

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