Sequential Therapy in Multiple Myeloma Guided by MRD Assessments

ClinicalTrials.gov ID: NCT05231629

Public ClinicalTrials.gov record NCT05231629. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 6, 2026, 8:27 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

MRD-Guided Sequential Therapy For Deep Response in Newly Diagnosed Multiple Myeloma - MASTER-2 Trial

Study identification

NCT ID: NCT05231629
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: University of Alabama at Birmingham; Other
Enrollment: 300 participants

Conditions and interventions

Conditions

Multiple Myeloma

Interventions

AHCT intensification, Dara-R consolidation, Dara-R maintenance Drug
AHCT intensification, Dara-R maintenance Drug
AHCT intensification, Tec-Dara consolidation, Tec-Dara maintenance Drug
Dara-VRd induction Drug
Dara-VRd intensification, Dara-R maintenance Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Dec 12, 2023
Primary completion: Nov 30, 2026
Completion: Nov 30, 2027
Last update posted: Jan 8, 2026

2023 – 2027

United States locations

U.S. sites: 10
U.S. states: 9
U.S. cities: 10

Facility	City	State	ZIP	Site status
University of Alabama at Birmingham	Birmingham	Alabama	35233	Recruiting
Colorado Blood Cancer Institute	Denver	Colorado	80218	Recruiting
Columbia University	New York	New York	10032	Recruiting
Oregon Health and Science University	Portland	Oregon	97239	Recruiting
Vanderbilt University	Nashville	Tennessee	37232	Recruiting
University of Texas Southwestern	Dallas	Texas	75390	Recruiting
University of Utah	Salt Lake City	Utah	84112	Recruiting
University of Washington	Seattle	Washington	98109	Recruiting
University of Wisconsin - Carbone	Madison	Wisconsin	53792	Recruiting
Medical College of Wisconsin	Milwaukee	Wisconsin	53226	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05231629, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Jan 8, 2026 · Synced May 6, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05231629 live on ClinicalTrials.gov.

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