ClinicalTrials.gov record
A Study of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Crohn's Disease
ClinicalTrials.gov ID: NCT05242471
Public ClinicalTrials.gov record NCT05242471. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2b Randomized, Double-blind, Active-and Placebo-controlled, Parallel-group, Multicenter Study to Evaluate the Efficacy and Safety of Induction and Maintenance Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Crohn's Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the efficacy of JNJ-78934804 at Week 48 compared to guselkumab and golimumab.
Study identification
- NCT ID
- NCT05242471
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 703 participants
Conditions and interventions
Conditions
Interventions
- Guselkumab Biological
- Golimumab Biological
- JNJ-78934804 Biological
- Placebo Drug
Biological · Drug
Eligibility (public fields only)
- Age range
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 22, 2022 (Actual)
- Primary completion
- May 23, 2025 (Actual)
- Completion
- Nov 5, 2029 (Estimated)
- Last update posted
- Sep 28, 2026
2022 – 2029
United States locations
- U.S. sites
- 90
- U.S. states
- 33
- U.S. cities
- 82
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama Liver Center | Birmingham | Alabama | 35233 | — |
| Del Sol Research Management, LLC | Tucson | Arizona | 85715 | — |
| Moore Clinical Trials, LLC | Little Rock | Arkansas | 72205 | — |
| Om Research LLC | Apple Valley | California | 92307 | — |
| Valley Gastroenterology Medical Group | Arcadia | California | 91006 | — |
| Southern California Research Center | Coronado | California | 92118 | — |
| Desert Gastroenterology Associates | Lancaster | California | 93534 | — |
| Cedars Sinai Medical Center | Los Angeles | California | 90048 | — |
| UCLA | Los Angeles | California | 90095 | — |
| Hoag Memorial Hospital | Newport Beach | California | 92658 | — |
| UCI Irvine Medical Center | Orange | California | 92868 | — |
| Medical Associates Research Group, Inc. | San Diego | California | 92123 | — |
| University of California San Francisco | San Francisco | California | 94115 | — |
| University of Colorado | Aurora | Colorado | 80045 | — |
| Medical Research Center of Connecticut | Hamden | Connecticut | 06518 | — |
| Yale University School Of Medicine | New Haven | Connecticut | 06510 | — |
| MedStar Georgetown University Hospital | Washington D.C. | District of Columbia | 20007 | — |
| Pioneer Research Solutions Inc. | Coconut Creek | Florida | 33066 | — |
| Homestead Associates in Research Inc | Homestead | Florida | 33032 | — |
| Osceola Mental Health D/B/A Park Place Behavioral Health Care | Kissimmee | Florida | 34741 | — |
| Florida Research Center Inc. | Lakewood Rch | Florida | 34211 | — |
| University of Miami Hospital | Miami | Florida | 33136 | — |
| Gastroenterology Group Of Naples | Naples | Florida | 34102 | — |
| Omega Research Consultants | Orlando | Florida | 32808 | — |
| Synergy Clinical Research | St. Petersburg | Florida | 33705 | — |
| GCP Clinical Research | Tampa | Florida | 33609 | — |
| Atlanta Gastroenterology Associates | Atlanta | Georgia | 30342 | — |
| University of Mississippi Medical Center | Atlanta | Georgia | 30342 | — |
| Gastroenterolgy Associates of Central GA | Macon | Georgia | 31201 | — |
| Gastrointestinal Specialists of Georgia | Marietta | Georgia | 30060 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| IU Health University Hospital | Indianapolis | Indiana | 46202 | — |
| Gastroenterology of Southern Indiana | New Albany | Indiana | 47150 | — |
| Cotton O'Neil Digestive Health Center | Topeka | Kansas | 66606 | — |
| Ascension via Christi Research | Wichita | Kansas | 67208 | — |
| Univ. of KS School of Med | Wichita | Kansas | 67214-3124 | — |
| Tri-State Gastroenterology Assoc | Crestview Hills | Kentucky | 41017 | — |
| University of Kentucky | Lexington | Kentucky | 40536 | — |
| Jewish Hospital | Louisville | Kentucky | 40202 | — |
| Gastroenterology Clinic of Acadiana | Lafayette | Louisiana | 70503 | — |
| Tandem Clinical Research | Marrero | Louisiana | 70072 | — |
| Ochsner Medical Center | New Orleans | Louisiana | 70121 | — |
| Chevy Chase Clinical Research | Chevy Chase | Maryland | 20815 | — |
| Lahey Hospital & Medical Center | Boston | Massachusetts | 02215-5400 | — |
| Brigham And Women's Hospital | Chestnut Hill | Massachusetts | 02467 | — |
| FC Research, LLC | South Dartmouth | Massachusetts | 02747 | — |
| Detroit Clinical Research Center | Livonia | Michigan | 48152 | — |
| Huron Gastroenterology Associates Center for Digestive Care | Ypsilanti | Michigan | 48197 | — |
| Gastrointestinal Associates LLP | Flowood | Mississippi | 39232 | — |
| Washington University | St Louis | Missouri | 63110 | — |
| Las Vegas Medical Research | Las Vegas | Nevada | 89113 | — |
| Care Access Las Vegas | Las Vegas | Nevada | 89148 | — |
| Dartmouth Hitchcock | Lebanon | New Hampshire | 03756 | — |
| Northwell Health | Great Neck | New York | 11021 | — |
| A1 Clinical Research | Jackson Heights | New York | 11372 | — |
| Weill Cornell Medical College | New York | New York | 10021 | — |
| Lenox Hill Hospital | New York | New York | 10075 | — |
| Mohawk Valley Endoscopy Center | Utica | New York | 13502-6313 | — |
| University of North Carolina | Chapel Hill | North Carolina | 27599-7080 | — |
| Tryon Medical Group | Charlotte | North Carolina | 28210 | — |
| PMG Research of Winston-Salem | Winston-Salem | North Carolina | 27103 | — |
| University Hospitals Case Medical Center | Cleveland | Ohio | 44106 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195-6501 | — |
| Northshore Gastroenterology Research, LLC | Westlake | Ohio | 44145 | — |
| The Oregon Clinic | Portland | Oregon | 97220-9428 | — |
| Susquehanna Gastroenterology Associates | Harrisburg | Pennsylvania | 17110-3673 | — |
| University of Pennsylvania - Perelman School of Medicine | Philadelphia | Pennsylvania | 19104 | — |
| Frontier Clinical Research | Smithfield | Pennsylvania | 15478 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Digestive Disease Associates | Rock Hill | South Carolina | 29732 | — |
| Saint Francis Hospital | Germantown | Tennessee | 38138 | — |
| Galen Medical Group | Hixson | Tennessee | 37343 | — |
| Etsu Quillen College Of Medicine | Johnson City | Tennessee | 37604 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37067 | — |
| Amel Med LLC Research | Austin | Texas | 78750 | — |
| Baylor University Medical Center | Dallas | Texas | 75242 | — |
| UT Southwestern Medical Center | Dallas | Texas | 75390-9063 | — |
| Accurate Clinical Research | Houston | Texas | 77034 | — |
| Gastroenterology Clinic Of San Antonio P A | San Antonio | Texas | 78229 | — |
| Texas Digestive Disease Consultants | Southlake | Texas | 76092 | — |
| Digestive Health Specialists | Tyler | Texas | 75701 | — |
| Care Access Research, Ogden | Ogden | Utah | 84403 | — |
| Care Access Research- Salt Lake City | Salt Lake City | Utah | 84124 | — |
| University of Virginia | Charlottesville | Virginia | 22908 | — |
| Hunter Holmes McGuire Veterans Affairs Medical Center | Richmond | Virginia | 23249 | — |
| Washington Gastroenterology, PLLC | Bellevue | Washington | 98004 | — |
| Swedish Medical Center | Seattle | Washington | 98104 | — |
| University of Washington Digestive Disease Center | Seattle | Washington | 98195 | — |
| Digestive Health Specialists 1 | Tacoma | Washington | 98405 | — |
| Marshall Health Clinical Research Center | Huntington | West Virginia | 25701 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 366 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05242471, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 28, 2026 · Synced Oct 24, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05242471 live on ClinicalTrials.gov.