Phase 3 Study of Teclistamab in Combination With Lenalidomide and Teclistamab Alone Versus Lenalidomide Alone in Participants With Newly Diagnosed Multiple Myeloma as Maintenance Therapy Following Autologous Stem Cell Transplantation

ClinicalTrials.gov ID: NCT05243797

Public ClinicalTrials.gov record NCT05243797. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 8, 2026, 10:44 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Phase 3 Study of Teclistamab in Combination With Lenalidomide and Teclistamab Alone Versus Lenalidomide Alone in Participants With Newly Diagnosed Multiple Myeloma as Maintenance Therapy Following Autologous Stem Cell Transplantation - MajesTEC-4

Study identification

NCT ID: NCT05243797
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: European Myeloma Network B.V.; Network
Enrollment: 1,594 participants

Conditions and interventions

Conditions

Multiple Myeloma

Interventions

Lenalidomide Drug
Teclistamab Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Sep 7, 2022
Primary completion: Mar 31, 2028
Completion: Mar 31, 2032
Last update posted: Mar 24, 2026

2022 – 2032

United States locations

U.S. sites: 40
U.S. states: 21
U.S. cities: 36

Facility	City	State	ZIP	Site status
Banner University Medical Center Tucson, University of Arizona	Phoenix	Arizona	85004	Not yet recruiting
UCLA Medical Center	Los Angeles	California	90095	Not yet recruiting
University of California-Davis Cancer Center	Sacramento	California	95817	Recruiting
University of California, San Diego (UCSD) Medical Center	San Diego	California	92093	Recruiting
University of Colorado Hospital	Aurora	Colorado	80045	Not yet recruiting
Colorado Blood Cancer Institute	Denver	Colorado	80218	Recruiting
Yale New Haven Hospital	New Haven	Connecticut	06519	Recruiting
Christiana Care	Newark	Delaware	19718	Recruiting
Sibley Memorial Hospital	Washington D.C.	District of Columbia	20016	Not yet recruiting
Blood & Marrow Transplant Center, Florida Hospital Medical Group	Orlando	Florida	32804	Not yet recruiting
Moffitt at Memorial Healthcare System	Tampa	Florida	33612	Not yet recruiting
Emory University Hospital	Atlanta	Georgia	30322	Not yet recruiting
University of Illinois Medical Center at Chicago	Chicago	Illinois	60612	Recruiting
Greenebaum Cancer Center UM of MD	Baltimore	Maryland	21201	Recruiting
John Hopkins	Baltimore	Maryland	21218	Recruiting
Tufts Medical Center	Boston	Massachusetts	02111	Recruiting
Beth Israel Deaconess Medical Center	Boston	Massachusetts	02215	Not yet recruiting
Dartmouth-Hitchcock Medical Center	Lebanon	New Hampshire	03756	Withdrawn
Mount Sinai Medical Center - 2	New York	New York	10029	Recruiting
Montefiore Medical Cente	The Bronx	New York	10467	Recruiting
Levine Cancer Institute	Charlotte	North Carolina	28204	Not yet recruiting
Duke University	Durham	North Carolina	27708	Recruiting
East Carolina University	Greenville	North Carolina	27858	Not yet recruiting
University of Cincinnati	Cincinnati	Ohio	45221	Recruiting
Seidman Cancer Center-University Hospitals Cleveland Medical Center	Cleveland	Ohio	44106	Recruiting
Ohio State Medical Center, James Cancer Center	Columbus	Ohio	43210	Recruiting
Ohio Health Research Institute	Columbus	Ohio	43214	Not yet recruiting
Lehigh Valley Health Network	Allentown	Pennsylvania	18103	Recruiting
Penn Medicine Lancaster General	Lancaster	Pennsylvania	17602	Not yet recruiting
Abramson Cancer Center University of Pennsylvania Medical Center	Philadelphia	Pennsylvania	19104	Recruiting
Fox Chase Cancer Center	Philadelphia	Pennsylvania	19111	Recruiting
UPMC Hillman Cancer Center	Pittsburgh	Pennsylvania	15232	Not yet recruiting
Medical University of South Carolina (MUSC)	Charleston	South Carolina	29425	Not yet recruiting
Gibbs Cancer Center	Spartanburg	South Carolina	29303	Not yet recruiting
Vanderbilt-Ingram Cancer Center (VICC)	Nashville	Tennessee	37240	Recruiting
Houston Methodist Hospital	Houston	Texas	77030	Recruiting
Virginia Oncology Associates	Norfolk	Virginia	23502	Recruiting
St Vincent HSHS (Green Bay Oncology)	Green Bay	Wisconsin	54301	Recruiting
University of Wisconsin Hospital and Clinics	Madison	Wisconsin	53792	Recruiting
Froedtert Memorial Lutheran Hospital	Milwaukee	Wisconsin	53226	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 171 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05243797, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Mar 24, 2026 · Synced May 8, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05243797 live on ClinicalTrials.gov.

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