Phase 3 Study of Teclistamab in Combination With Lenalidomide and Teclistamab Alone Versus Lenalidomide Alone in Participants With Newly Diagnosed Multiple Myeloma as Maintenance Therapy Following Autologous Stem Cell Transplantation
Public ClinicalTrials.gov record NCT05243797. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Phase 3 Study of Teclistamab in Combination With Lenalidomide and Teclistamab Alone Versus Lenalidomide Alone in Participants With Newly Diagnosed Multiple Myeloma as Maintenance Therapy Following Autologous Stem Cell Transplantation - MajesTEC-4
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a multicenter, randomized, open-label, Phase 3 study in participants with newly diagnosed multiple myeloma to evaluate the benefits of teclistamab in combination with lenalidomide and teclistamab alone versus lenalidomide alone as maintenance therapy after autologous stem cell transplant.
Study identification
- NCT ID
- NCT05243797
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,594 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 7, 2022
- Primary completion
- Mar 31, 2028
- Completion
- Mar 31, 2032
- Last update posted
- Jun 3, 2026
2022 – 2032
United States locations
- U.S. sites
- 42
- U.S. states
- 22
- U.S. cities
- 37
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Banner University Medical Center Tucson, University of Arizona | Phoenix | Arizona | 85004 | Recruiting |
| UCLA Medical Center | Los Angeles | California | 90095 | Not yet recruiting |
| University of California-Davis Cancer Center | Sacramento | California | 95817 | Recruiting |
| University of California, San Diego (UCSD) Medical Center | San Diego | California | 92093 | Recruiting |
| University of Colorado Hospital | Aurora | Colorado | 80045 | Recruiting |
| Colorado Blood Cancer Institute | Denver | Colorado | 80218 | Recruiting |
| Yale New Haven Hospital | New Haven | Connecticut | 06519 | Recruiting |
| Christiana Care | Newark | Delaware | 19718 | Recruiting |
| Sibley Memorial Hospital | Washington D.C. | District of Columbia | 20016 | Recruiting |
| AdventHealth/Blood & Marrow Transplant Center, Florida Hospital Medical Group | Orlando | Florida | 32804 | Recruiting |
| Moffitt at Memorial Healthcare System | Tampa | Florida | 33612 | Recruiting |
| Emory University Hospital | Atlanta | Georgia | 30322 | Recruiting |
| University of Chicago | Chicago | Illinois | 3000168 | Not yet recruiting |
| University of Illinois Medical Center at Chicago | Chicago | Illinois | 60612 | Recruiting |
| Greenebaum Cancer Center UM of MD | Baltimore | Maryland | 21201 | Recruiting |
| John Hopkins | Baltimore | Maryland | 21218 | Recruiting |
| Tufts Medical Center | Boston | Massachusetts | 02111 | Recruiting |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | Recruiting |
| Henry Ford St. John Hospital | Grosse Pointe Woods | Michigan | 3000169 | Not yet recruiting |
| Dartmouth-Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | Withdrawn |
| Mount Sinai Medical Center - 2 | New York | New York | 10029 | Recruiting |
| Montefiore Medical Cente | The Bronx | New York | 10467 | Recruiting |
| Levine Cancer Institute | Charlotte | North Carolina | 28204 | Recruiting |
| Duke University | Durham | North Carolina | 27710 | Recruiting |
| East Carolina University | Greenville | North Carolina | 27858 | Not yet recruiting |
| University of Cincinnati | Cincinnati | Ohio | 45221 | Recruiting |
| Seidman Cancer Center-University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | Recruiting |
| Ohio State Medical Center, James Cancer Center | Columbus | Ohio | 43210 | Recruiting |
| Ohio Health Research Institute | Columbus | Ohio | 43214 | Recruiting |
| Lehigh Valley Health Network | Allentown | Pennsylvania | 18103 | Recruiting |
| Penn Medicine Lancaster General | Lancaster | Pennsylvania | 17602 | Not yet recruiting |
| Abramson Cancer Center University of Pennsylvania Medical Center | Philadelphia | Pennsylvania | 19104 | Recruiting |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111 | Recruiting |
| UPMC Hillman Cancer Center | Pittsburgh | Pennsylvania | 15232 | Not yet recruiting |
| Medical University of South Carolina (MUSC) | Charleston | South Carolina | 29425 | Recruiting |
| Gibbs Cancer Center | Spartanburg | South Carolina | 29303 | Recruiting |
| Vanderbilt-Ingram Cancer Center (VICC) | Nashville | Tennessee | 37232 | Recruiting |
| Houston Methodist Hospital | Houston | Texas | 77030 | Recruiting |
| Virginia Oncology Associates | Norfolk | Virginia | 23502 | Recruiting |
| St Vincent HSHS (Green Bay Oncology) | Green Bay | Wisconsin | 54301 | Recruiting |
| University of Wisconsin Hospital and Clinics | Madison | Wisconsin | 53792 | Recruiting |
| Froedtert Memorial Lutheran Hospital | Milwaukee | Wisconsin | 53226 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 170 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05243797, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 3, 2026 · Synced Sep 2, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05243797 live on ClinicalTrials.gov.