A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)
Public ClinicalTrials.gov record NCT05254743. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3 Open-Label, Randomized Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (BRUIN-CLL-314)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of Part 1 of this study is to compare the efficacy and safety of pirtobruitinib (LOXO-305) to ibrutinib in participants with CLL/SLL; participants may or may not have already had treatment for their cancer. The purpose of Part 2 of this study evaluates pirtobrutinib monotherapy in treatment-naïve participants with CLL/SLL with 17p deletions. Participation could last up to six years for Part 1. Participation could last up to 2 years for Part 2.
Study identification
- NCT ID
- NCT05254743
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 737 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 21, 2022
- Primary completion
- Sep 30, 2027
- Completion
- Dec 31, 2027
- Last update posted
- Aug 16, 2026
2022 – 2028
United States locations
- U.S. sites
- 19
- U.S. states
- 11
- U.S. cities
- 18
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Pacific Cancer Medical Center, Inc | Anaheim | California | 92801 | Recruiting |
| TOI Clinical Research | Cerritos | California | 90703 | Recruiting |
| Stanford School of Medicine-Cancer Clinical Trials Office | Palo Alto | California | 94305 | Recruiting |
| California Cancer Associates for Research and Excellence | San Marcos | California | 92069 | Active, not recruiting |
| Florida Cancer Specialists | Fort Myers | Florida | 33916-2233 | Recruiting |
| Cancer Specialists of North Florida -St Augustine | Saint Augustine | Florida | 32086 | Recruiting |
| Florida Cancer Specialists East | West Palm Beach | Florida | 33401 | Recruiting |
| Hematology Oncology Clinic | Baton Rouge | Louisiana | 70809 | Active, not recruiting |
| Tulane Cancer Center Office of Clinical Research | New Orleans | Louisiana | 70112 | Active, not recruiting |
| American Oncology Partners of Maryland, PA | Bethesda | Maryland | 20817 | Recruiting |
| St. Vincent Frontier Cancer Center | Billings | Montana | 59102 | Recruiting |
| Cancer Care Associates Of York | York | Pennsylvania | 17403 | Active, not recruiting |
| Prisma Health Cancer Institute | Greenville | South Carolina | 29605 | Active, not recruiting |
| Sarah Cannon Research Institute SCRI | Nashville | Tennessee | 37203 | Recruiting |
| Kelsey Research Foundation | Houston | Texas | 77025 | Active, not recruiting |
| Lumi Research | Kingwood | Texas | 77339 | Recruiting |
| Virginia Cancer Institute | Richmond | Virginia | 23230 | Recruiting |
| Medical Oncology Associates, PS | Spokane | Washington | 99208 | Recruiting |
| MultiCare Health System Institute for Research and Innovation | Spokane | Washington | 99218 | Active, not recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 124 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05254743, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 16, 2026 · Synced Sep 19, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05254743 live on ClinicalTrials.gov.