Study of Efficacy and Safety of LNP023 in Participants With Active Lupus Nephritis Class III-IV, +/- V
Public ClinicalTrials.gov record NCT05268289. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
An Adaptive, Randomized, Double-blind, Dose Exploration, Parallel Group, Placebo Controlled, Multicenter Phase 2 Trial to Evaluate the Efficacy, Safety and Tolerability of LNP023 in Combination With Standard-of-care With and Without Oral Corticosteroids in Patients With Active Lupus Nephritis Class III-IV, +/- V
Study identification
- NCT ID
- NCT05268289
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Novartis Pharmaceuticals
- Industry
- Enrollment
- 240 participants
Conditions and interventions
Conditions
Interventions
- Iptacopan (part 1) Drug
- Iptacopan (part 2) Drug
- Iptacopan + placebo Drug
- Placebo + standard of care Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 100 Years
- Sex
- All
- Healthy volunteers
- Not listed
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 9, 2022
- Primary completion
- Mar 18, 2026
- Completion
- Sep 27, 2028
- Last update posted
- Apr 19, 2026
2022 – 2028
United States locations
- U.S. sites
- 25
- U.S. states
- 16
- U.S. cities
- 25
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| AKDHC Medical Research ServicesLLC | Phoenix | Arizona | 85016 | Withdrawn |
| Kaiser Permanente Fontana | Fontana | California | 92335 | Withdrawn |
| Univ Calif Irvine | Irvine | California | 92697 | Active, not recruiting |
| Ronald Reagan UCLA Medical Center | Los Angeles | California | 90095 | Recruiting |
| Loma Linda University | San Bernardino | California | 92408 | Active, not recruiting |
| Olive View UCLA Medical Center | Sylmar | California | 91342 | Active, not recruiting |
| University of Colorado Denver | Aurora | Colorado | 80045 | Recruiting |
| Royal Research Corp | Hollywood | Florida | 33021 | Recruiting |
| Mayo Clinic Jacksonville | Jacksonville | Florida | 32224 | Recruiting |
| Nephrology Associates Of Central FL | Orlando | Florida | 32806 | Active, not recruiting |
| Florida Kidney Physicians | Riverview | Florida | 33578 | Recruiting |
| Nep Assoc of Northern Illinois | Hinsdale | Illinois | 60521 | Active, not recruiting |
| Wichita Community Clcl Onco Program | Wichita | Kansas | 67214 | Recruiting |
| Ochsner Health System | New Orleans | Louisiana | 70121 | Recruiting |
| Johns Hopkins Hospital | Baltimore | Maryland | 21287 | Active, not recruiting |
| Brigham and Womens Hosp Harvard Med School | Boston | Massachusetts | 02115 | Recruiting |
| Mayo Clinic Rochester | Rochester | Minnesota | 55905 | Withdrawn |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198 | Active, not recruiting |
| Stony Brook Internists PC | East Setauket | New York | 11733 | Recruiting |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | Recruiting |
| Temple University | Philadelphia | Pennsylvania | 19140 | Recruiting |
| Allegheny Health Network | Pittsburgh | Pennsylvania | 15212 | Withdrawn |
| Dallas Nephrology Associates | Dallas | Texas | 75204 | Active, not recruiting |
| Prolato Clinical Research Center | Houston | Texas | 77054 | Recruiting |
| Virginia Commonwealth University | Richmond | Virginia | 23298 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 77 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05268289, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 19, 2026 · Synced Apr 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05268289 live on ClinicalTrials.gov.