A Rollover Study to Evaluate the Long-Term Safety and Efficacy of Ocrelizumab In Patients With Multiple Sclerosis
Public ClinicalTrials.gov record NCT05269004. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Single-Arm, Open-Label, Extension, Rollover Study To Evaluate The Long-Term Safety And Efficacy Of Ocrelizumab In Patients With Multiple Sclerosis
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a Phase IIIb, single-arm, multicenter, OLE study. Participants receiving ocrelizumab as an investigational medicinal product (IMP) in a Roche sponsored Parent study who continue to receive ocrelizumab or are in safety follow-up at the time of the closure of their respective Parent study (WA21092, WA21093 or WA25046) are eligible for enrollment in this extension study. Participants who will continue ocrelizumab treatment will receive IMP based on the dosage and administration received at the time of rollover from the Parent study.
Study identification
- NCT ID
- NCT05269004
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,300 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 3, 2022 (Actual)
- Primary completion
- Dec 31, 2027 (Estimated)
- Completion
- Dec 31, 2027 (Estimated)
- Last update posted
- Jul 29, 2026
2022 – 2027
United States locations
- U.S. sites
- 50
- U.S. states
- 26
- U.S. cities
- 44
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Barrow Neurological Institute | Phoenix | Arizona | 85013 | — |
| Arizona Neuroscience Research LLC | Phoenix | Arizona | 85032 | — |
| MS Center of California | Laguna Hills | California | 92653 | — |
| Stanford Hospital and Clinics | Palo Alto | California | 94304 | — |
| University of California San Francisco | San Francisco | California | 94117 | — |
| University of California San Francisco | San Francisco | California | 94143 | — |
| University of Colorado - Anschutz Medical Campus (University of Colorado Health Sciences Center) | Aurora | Colorado | 80045 | — |
| Advanced Neurosciences Research LLC | Fort Collins | Colorado | 80528 | — |
| Neurology Associates PA | Maitland | Florida | 32751 | — |
| University of Miami | Miami | Florida | 33136 | — |
| Neurological Services of Orlando | Orlando | Florida | 32806 | — |
| University of South Florida | Tampa | Florida | 33612 | — |
| Vero Beach Neurology and Research Institute | Vero Beach | Florida | 32860 | — |
| Atlanta Neuroscience Institute | Atlanta | Georgia | 30327 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| Consultants in Neurology Ltd | Northbrook | Illinois | 60062 | — |
| Indiana Univ School of Med | Indianapolis | Indiana | 46202 | — |
| Kansas University Medical Center | Kansas City | Kansas | 66160 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Wayne State University | Detroit | Michigan | 48201 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Michigan Institute for Neurological Disorders | Farmington Hills | Michigan | 48334 | — |
| Minneapolis Clinic of Neurology | Golden Valley | Minnesota | 55422 | — |
| University of Minnesota | Minneapolis | Minnesota | 55414 | — |
| Washington University | St Louis | Missouri | 63110 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198-8440 | — |
| Rutgers New Jersey Medical School Department of Neurology | Newark | New Jersey | 07103 | — |
| Holy Name Hospital | Teaneck | New Jersey | 07666 | — |
| University of New Mexico | Albuquerque | New Mexico | 87131-0001 | — |
| South Shore Neurologic Associates PC | Patchogue | New York | 11772 | — |
| SUNY at Stony Brook | Stony Brook | New York | 11790 | — |
| OnSite Clinical Solutions LLC | Charlotte | North Carolina | 28203 | — |
| The Neurological Institute PA | Charlotte | North Carolina | 28204 | — |
| Atrium Health | Charlotte | North Carolina | 28207 | — |
| Raleigh Neurology Associates | Raleigh | North Carolina | 27607 | — |
| University Neurology Inc. | Cincinnati | Ohio | 45267-0502 | — |
| Columbus Neuroscience | Westerville | Ohio | 43082 | — |
| Oklahoma Medical Research Foundation | Oklahoma City | Oklahoma | 73104-5046 | — |
| Providence Neurological Specialties | Portland | Oregon | 97225 | — |
| Abington Neurological Associates | Abington | Pennsylvania | 19001 | — |
| Rhode Island Hospital | Providence | Rhode Island | 02903 | — |
| Neurology Clinic PC | Cordova | Tennessee | 38018 | — |
| Sibyl Wray MD Neurology PC | Knoxville | Tennessee | 37934 | — |
| Baylor College of Medicine | Houston | Texas | 77030 | — |
| Uni of Texas Health Science Center At Houston | Houston | Texas | 77054 | — |
| Bhupesh Dihenia M.D. P.A. | Lubbock | Texas | 79410 | — |
| Neurology Center of San Antonio | San Antonio | Texas | 78258 | — |
| University of Vermont Medical Center | Burlington | Vermont | 05401 | — |
| Swedish Neuroscience Research | Seattle | Washington | 98122 | — |
| MultiCare Health System Institute for Research and Innovation | Tacoma | Washington | 98405 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 186 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05269004, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 29, 2026 · Synced Oct 25, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05269004 live on ClinicalTrials.gov.