A Study to Investigate LYL797 in Adults With Solid Tumors
Public ClinicalTrials.gov record NCT05274451. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 1 Study to Assess the Safety and Efficacy of LYL797, ROR1-Targeting CAR T Cells, in Adults With Relapsed and/or Refractory Solid-Tumor Malignancies
Study identification
- NCT ID
- NCT05274451
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 1
- Lead sponsor
- Lyell Immunopharma, Inc.
- Industry
- Enrollment
- 57 participants
Conditions and interventions
Conditions
- Advanced Breast Cancer
- Advanced Lung Carcinoma
- Endometrial Cancer
- Endometrioid Tumor
- Fallopian Tube Cancer
- High Grade Serous Carcinoma
- NSCLC
- NSCLC Stage IV
- NSCLC, Recurrent
- Non Small Cell Lung Cancer
- Non Small Cell Lung Cancer Metastatic
- Non-Small Cell Carcinoma of Lung, TNM Stage 4
- Non-small Cell Lung Cancer
- Ovarian Cancer
- Ovarian Epithelial Cancer
- Platinum-resistant Ovarian Cancer
- Primary Peritoneal Carcinoma
- Recurrent Breast Cancer
- Recurrent NSCLC
- Relapse/Recurrence
- Relapsed Cancer
- TNBC - Triple-Negative Breast Cancer
- Triple Negative Breast Cancer
Interventions
- LYL797 Biological
Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 28, 2022
- Primary completion
- Nov 26, 2024
- Completion
- Nov 26, 2024
- Last update posted
- Jun 30, 2025
2022 – 2024
United States locations
- U.S. sites
- 18
- U.S. states
- 16
- U.S. cities
- 18
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Mayo Clinic | Scottsdale | Arizona | 85259 | — |
| University of California, Los Angeles | Santa Monica | California | 90404 | — |
| Yale New Haven Hospital | New Haven | Connecticut | 06510 | — |
| Georgetown University | Washington D.C. | District of Columbia | 20007 | — |
| Mayo Clinic | Jacksonville | Florida | 32224 | — |
| University of Miami | Miami | Florida | 33136 | — |
| University of Chicago | Chicago | Illinois | 60637 | — |
| Karmanos Cancer Institute | Detroit | Michigan | 48201 | — |
| Mayo Clinic | Rochester | Minnesota | 55902 | — |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | — |
| Montefiore Medical Center | The Bronx | New York | 10461 | — |
| University of Oklahoma | Oklahoma City | Oklahoma | 73104 | — |
| Oregon Health and Science University Hospital | Portland | Oregon | 97239 | — |
| Sidney Kimmel Cancer Center, Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| Sarah Cannon Research Institute and Tennessee Oncology | Nashville | Tennessee | 37203 | — |
| MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| Fred Hutchinson Cancer Research Center | Seattle | Washington | 98109 | — |
| Froedtert Hospital, Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05274451, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jun 30, 2025 · Synced May 20, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05274451 live on ClinicalTrials.gov.