A Phase 2b, Study of Linsitinib in Subjects With Active, Moderate to Severe Thyroid Eye Disease (TED)
Public ClinicalTrials.gov record NCT05276063. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2b, Randomized, Double-Mask, Placebo-Controlled, Study to Evaluate the Safety, Pharmacokinetics and Efficacy of Linsitinib in Subjects With Active, Moderate to Severe Thyroid Eye Disease (TED)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The overall objective is to study the safety, pharmacokinetics and efficacy of linsitinib (a small molecule IGF-1R inhibitor) administered orally twice daily (BID) vs. placebo, at 24 weeks in the treatment of subjects with active, moderate to severe thyroid eye disease (TED).
Study identification
- NCT ID
- NCT05276063
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Enrollment
- 90 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 1, 2022 (Actual)
- Primary completion
- Oct 15, 2024 (Actual)
- Completion
- Sep 26, 2025 (Actual)
- Last update posted
- Sep 23, 2026
2022 – 2025
United States locations
- U.S. sites
- 19
- U.S. states
- 13
- U.S. cities
- 18
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Thrive Health Research | Beverly Hills | California | 90210 | — |
| UC San Diego Health | La Jolla | California | 92093 | — |
| UCLA | Los Angeles | California | 90095 | — |
| Byers Eye Institute - Stanford University | Palo Alto | California | 94303 | — |
| Bascom Palmer Eye Institute | Miami | Florida | 33136 | — |
| Center for Excellence in Eye Care | Miami | Florida | 33176 | — |
| Sarasota Retina Institute | Sarasota | Florida | 34239 | — |
| Chicago Oculofacial Plastic Surgery | Chicago | Illinois | 60614 | — |
| Wolfe Eye Clinic | West Des Moines | Iowa | 50266 | — |
| Mass Eye and Ear | Boston | Massachusetts | 02114 | — |
| Kellogg Eye Center | Ann Arbor | Michigan | 48105 | — |
| Kahana Oculoplastic & Orbital Surgery | Livonia | Michigan | 48152 | — |
| Washington University in St. Louis/Barnes Jewish Hospital | Creve Coeur | Missouri | 63141 | — |
| Columbia University | New York | New York | 10032 | — |
| Wake Forest Baptist Health Eye Center | Winston-Salem | North Carolina | 27157 | — |
| Oregon Health and Science University | Portland | Oregon | 97239 | — |
| Neuro-Eye Clinical Trials, Inc. | Bellaire | Texas | 77401 | — |
| Eyelid Center of Utah | Salt Lake City | Utah | 84102 | — |
| West Virginia University Eye Institute | Morgantown | West Virginia | 26506 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 11 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05276063, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 23, 2026 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05276063 live on ClinicalTrials.gov.