A Study to Assess Safety of ABBV-916 and How Intravenous ABBV-916 Moves Through Body and Affects Brain Amyloid Plaque Clearance in Adult Participants (Aged 50-90 Years) With Early Alzheimer's Disease
Public ClinicalTrials.gov record NCT05291234. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, Efficacy, Pharmacokinetics and Pharmacodynamics of ABBV-916 in Subjects With Early Alzheimer's Disease
Study identification
- NCT ID
- NCT05291234
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- AbbVie
- Industry
- Enrollment
- 106 participants
Conditions and interventions
Conditions
Interventions
- ABBV-916 Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 50 Years to 90 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 14, 2022
- Primary completion
- Nov 18, 2025
- Completion
- Nov 18, 2025
- Last update posted
- Dec 9, 2025
2022 – 2025
United States locations
- U.S. sites
- 32
- U.S. states
- 9
- U.S. cities
- 26
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Tucson Neuroscience Research /ID# 244957 | Tucson | Arizona | 85710-6152 | — |
| Irvine Clinical Research /ID# 239469 | Irvine | California | 92614 | — |
| Artemis Institute for Clinical Research - San Diego /ID# 244508 | San Diego | California | 92103-2204 | — |
| Pacific Research Network, Inc. /ID# 244083 | San Diego | California | 92103 | — |
| Syrentis Clinical Research /ID# 239682 | Santa Ana | California | 92705 | — |
| Aventura Neurological Associates /ID# 243892 | Aventura | Florida | 33180 | — |
| Charter Research - Lady Lake /ID# 244657 | Lady Lake | Florida | 32162 | — |
| JEM Research Institute /ID# 239122 | Lake Worth | Florida | 33462-1141 | — |
| ClinCloud - Maitland /ID# 244507 | Maitland | Florida | 32751 | — |
| ClinCloud LLC - Viera/Melbourne /ID# 240635 | Melbourne | Florida | 32940-8288 | — |
| Merritt Island Medical Research /ID# 239495 | Merritt Island | Florida | 32952-3616 | — |
| Optimus U /ID# 245868 | Miami | Florida | 33125-4013 | — |
| Finlay Medical Research /ID# 245996 | Miami | Florida | 33126 | — |
| Allied Biomedical Res Inst Inc /ID# 244823 | Miami | Florida | 33155 | — |
| Renstar Medical Research /ID# 240153 | Ocala | Florida | 34470 | — |
| K2 Medical Research - Ocoee /ID# 246849 | Ocoee | Florida | 34761-4547 | — |
| K2 Medical Research - Orlando - South Orlando Avenue /ID# 243919 | Orlando | Florida | 32751 | — |
| Charter Research - Winter Park /ID# 244778 | Orlando | Florida | 32803-1839 | — |
| Headlands Research - Orlando /ID# 239119 | Orlando | Florida | 32819 | — |
| Neurology Associates Ormond Beach /ID# 245527 | Ormond Beach | Florida | 32174 | — |
| IMIC Inc. Medical Research /ID# 245900 | Palmetto Bay | Florida | 33157 | — |
| Alzheimer's Research and Treatment Center - Stuart /ID# 245477 | Stuart | Florida | 34997-5765 | — |
| Alzheimer's Research and Treatment Center - Wellington /ID# 245201 | Wellington | Florida | 33414 | — |
| Premiere Research Institute - Palm Beach /ID# 240108 | West Palm Beach | Florida | 33407-3209 | — |
| Clinical Site Partners (CSP) - Orlando /ID# 245127 | Winter Park | Florida | 32789-4681 | — |
| Conquest Research /ID# 243916 | Winter Park | Florida | 32789 | — |
| Columbus Memory Center /ID# 245054 | Columbus | Georgia | 31909 | — |
| QUEST Research Institute /ID# 239459 | Farmington Hills | Michigan | 48334-2977 | — |
| Advanced Memory Research Institute of NJ /ID# 239533 | Toms River | New Jersey | 08755-5043 | — |
| Keystone Clinical Studies LLC /ID# 239973 | Plymouth Meeting | Pennsylvania | 19462 | — |
| Clinical Trials of Texas, Inc /ID# 244917 | San Antonio | Texas | 78229 | — |
| Re:Cognition Health - Fairfax VA /ID# 239501 | Fairfax | Virginia | 22031-5207 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05291234, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 9, 2025 · Synced May 20, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05291234 live on ClinicalTrials.gov.