Evaluation of Rifaximin SSD for Delaying Encephalopathy Decompensation in Patients With Cirrhosis
Public ClinicalTrials.gov record NCT05297448. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Assess the Efficacy and Safety of Rifaximin Soluble Solid Dispersion (SSD) for the Delay of Encephalopathy Decompensation in Cirrhosis
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Study RNLC3132 is a Phase 3, randomized, double-blind, placebo-controlled, multicenter study to assess the efficacy and safety of rifaximin SSD-40mg IR for the delay of the first episode of overt hepatic encephalopathy (OHE) decompensation in liver cirrhosis, defined by the presence of medically controlled ascites.
Study identification
- NCT ID
- NCT05297448
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 466 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 3, 2022 (Actual)
- Primary completion
- Jan 2026 (Estimated)
- Completion
- Jan 2026 (Estimated)
- Last update posted
- Sep 10, 2025
2022 – 2026
United States locations
- U.S. sites
- 90
- U.S. states
- 25
- U.S. cities
- 73
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Bausch Site 591 | Homewood | Alabama | 35209 | — |
| Bausch Site 445 | Chandler | Arizona | 85224 | — |
| Bausch Site 453 | Sun City | Arizona | 85351 | — |
| Bausch Site 587 | Tucson | Arizona | 85715 | — |
| Bausch Site 550 | Bakersfield | California | 93309 | — |
| Bausch Site 415 | Coronado | California | 92118 | — |
| Bausch Site 585 | Covina | California | 91722 | — |
| Bausch Site 585 | Covina | California | 91723 | — |
| Bausch Site 592 | Fresno | California | 93720 | — |
| Bausch Site 582 | Lancaster | California | 93534 | — |
| Bausch Site 590 | Long Beach | California | 90808 | — |
| Bausch Site 414 | Los Angeles | California | 90067 | — |
| Bausch Site 405 | Orange | California | 92868 | — |
| Bausch Site 482 | Valencia | California | 91355 | — |
| Bausch Site 575 | Colorado Springs | Colorado | 80907 | — |
| Bausch Site 425 | Doral | Florida | 33122 | — |
| Bausch Site 449 | Hialeah | Florida | 33012 | — |
| Bausch Site 558 | Hialeah | Florida | 33012 | — |
| Bausch Site 418 | Hialeah | Florida | 33013 | — |
| Bausch Site 468 | Hollywood | Florida | 33024 | — |
| Bausch Site 495 | Miami | Florida | 23229 | — |
| Bausch Site 543 | Miami | Florida | 33032 | — |
| Bausch Site 479 | Miami | Florida | 33125 | — |
| Bausch Site 428 | Miami | Florida | 33126 | — |
| Bausch Site 470 | Miami | Florida | 33134 | — |
| Bausch Site 486 | Miami | Florida | 33144 | — |
| Bausch Site 552 | Miami | Florida | 33165 | — |
| Bausch Site 594 | Miami | Florida | 33165 | — |
| Bausch Site 456 | Miami | Florida | 33175 | — |
| Bausch Site 458 | Miami | Florida | 33176 | — |
| Bausch Site 435 | Miami | Florida | 33186 | — |
| Bausch Site 452 | Miami Lakes | Florida | 33016 | — |
| Bausch Site 431/443 | Ocala | Florida | 34471 | — |
| Bausch Site 450 | Ocala | Florida | 34471 | — |
| Bausch Site 446 | Ocoee | Florida | 34761 | — |
| Bausch Site 421 | Orange City | Florida | 32763 | — |
| Bausch Site 596 | Orlando | Florida | 32808 | — |
| Bausch Site 537 | Palmetto Bay | Florida | 33157 | — |
| Bausch Site 407 | Port Orange | Florida | 32127 | — |
| Bausch Site 454 | Wellington | Florida | 33467 | — |
| Bausch Site 429 | Zephyrhills | Florida | 33542 | — |
| Bausch Site 577 | Macon | Georgia | 31201 | — |
| Bausch Site 475 | Gurnee | Illinois | 60031 | — |
| Bausch Site 588 | South Bend | Indiana | 46635 | — |
| Bausch Site 466 | West Des Moines | Iowa | 50266 | — |
| Bausch Site 524 | Topeka | Kansas | 66606 | — |
| Bausch Site 457 | Lafayette | Louisiana | 70503 | — |
| Bausch Site 531 | Marrero | Louisiana | 70072 | — |
| Bausch Site 488 | Metairie | Louisiana | 70006 | — |
| Bausch Site 413 | New Orleans | Louisiana | 70125 | — |
| Bausch Site 442 | Shreveport | Louisiana | 71105 | — |
| Bausch Site 583 | Greenbelt | Maryland | 20770 | — |
| Bausch Site 463 | Flowood | Mississippi | 39232 | — |
| Bausch Site 460 | Jefferson City | Missouri | 65109 | — |
| Bausch Site 598 | Florham Park | New Jersey | 07932 | — |
| Bausch Site 597 | Freehold | New Jersey | 07728 | — |
| Bausch Site 411 | Sparta | New Jersey | 07871 | — |
| Bausch Site 455 | Toms River | New Jersey | 08755 | — |
| Bausch Site 436 | East Syracuse | New York | 13057 | — |
| Bausch Site 401 | The Bronx | New York | 10467 | — |
| Bausch Site 427 | Asheville | North Carolina | 28801 | — |
| Bausch Site 494 | Monroe | North Carolina | 28112 | — |
| Bausch Site 422 | Smithfield | North Carolina | 27577 | — |
| Bausch Site 410 | Dayton | Ohio | 45414 | — |
| Bausch Site 580 | Liberty Township | Ohio | 45044 | — |
| Bausch Site 403 | Springboro | Ohio | 45066 | — |
| Bausch Site 472 | Westlake | Ohio | 44145 | — |
| Bausch Site 581 | Allentown | Pennsylvania | 18104 | — |
| Bausch Site 400 | Harrisburg | Pennsylvania | 17110 | — |
| Bausch Site 576 | Philadelphia | Pennsylvania | 19104 | — |
| Bausch Site 484 | Providence | Rhode Island | 02905 | — |
| Bausch Site 599 | Columbia | South Carolina | 29204 | — |
| Bausch Site 480 | Summerville | South Carolina | 29486 | — |
| Bausch Site 423 | Chattanooga | Tennessee | 37421 | — |
| Bausch Site 434 | Chattanooga | Tennessee | 37421 | — |
| Bausch Site 579 | Hermitage | Tennessee | 37076 | — |
| Bausch Site 600 | Union City | Tennessee | 38261 | — |
| Bausch Site 406 | Dallas | Texas | 75390 | — |
| Bausch Site 519 | Denison | Texas | 75929 | — |
| Bausch Site 437 | Houston | Texas | 77074 | — |
| Bausch Site 447 | Humble | Texas | 77346 | — |
| Bausch Site 448 | San Marcos | Texas | 78130 | — |
| Bausch Site 409 | Waco | Texas | 76712 | — |
| Bausch Site 416 | Wichita Falls | Texas | 76301 | — |
| Bausch Site 402 | Burlington | Vermont | 05401 | — |
| Bausch Site 559 | Norfolk | Virginia | 23502 | — |
| Bausch Site 424 | Richmond | Virginia | 23226 | — |
| Bausch Site 490 | Richmond | Virginia | 23229 | — |
| Bausch Site 595 | Richmond | Virginia | 23236 | — |
| Bausch Site 404 | Roanoke | Virginia | 24014 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 98 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05297448, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 10, 2025 · Synced Oct 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05297448 live on ClinicalTrials.gov.