A Study of LOXO-783 in Patients With Breast Cancer/Other Solid Tumors
Public ClinicalTrials.gov record NCT05307705. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Study of LOXO-783 Administered as Monotherapy and in Combination With Anticancer Therapies for Patients With Advanced Breast Cancer and Other Solid Tumors With a PIK3CA H1047R Mutation
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The main purpose of this study is to learn more about the safety, side effects, and effectiveness of LOXO-783. LOXO-783 may be used to treat breast cancer and other solid tumors that have a change in a particular gene (known as the PIK3CA gene). Participation could last up to 36 months (3 years) and possibly longer if the disease does not get worse.
Study identification
- NCT ID
- NCT05307705
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 1
- Enrollment
- 260 participants
Conditions and interventions
Conditions
Interventions
- LOXO-783 Drug
- Fulvestrant Drug
- Imlunestrant Drug
- Abemaciclib Drug
- Anastrozole, Exemestane, or Letrozole Drug
- Paclitaxel Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 10, 2022
- Primary completion
- Nov 30, 2026
- Completion
- Nov 30, 2026
- Last update posted
- Aug 6, 2026
2022 – 2026
United States locations
- U.S. sites
- 17
- U.S. states
- 10
- U.S. cities
- 15
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Mayo Clinic of Scottsdale | Scottsdale | Arizona | 85259 | Not yet recruiting |
| UCLA Medical Center | Los Angeles | California | 90095 | Completed |
| UCSF Medical Center at Mission Bay | San Francisco | California | 94158 | Recruiting |
| Stanford University Hospital | Stanford | California | 94305 | Recruiting |
| Mayo Clinic | Jacksonville | Florida | 32224 | Not yet recruiting |
| Winship Cancer Center Emory University | Atlanta | Georgia | 30322 | Completed |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | Completed |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02215 | Not yet recruiting |
| Mayo Clinic | Rochester | Minnesota | 55905-0002 | Recruiting |
| Washington University Medical School | St Louis | Missouri | 63110 | Not yet recruiting |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | Completed |
| Wilmot Cancer Institute | Rochester | New York | 14642 | Not yet recruiting |
| Tennessee Oncology PLLC | Nashville | Tennessee | 37203 | Completed |
| Texas Oncology-Baylor Charles A. Sammons Cancer Center | Dallas | Texas | 75246 | Not yet recruiting |
| UT Southwestern Medical Center | Dallas | Texas | 75390-8884 | Recruiting |
| University of Texas MD Anderson Cancer Center | Houston | Texas | 77030 | Not yet recruiting |
| South Texas Accelerated Research Therapeutics (START) | San Antonio | Texas | 78229 | Not yet recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 33 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05307705, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 6, 2026 · Synced Sep 2, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05307705 live on ClinicalTrials.gov.