A Study to Find Out Whether BI 1015550 Improves Lung Function in People With Progressive Fibrosing Interstitial Lung Diseases (PF-ILDs)
Public ClinicalTrials.gov record NCT05321082. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Double Blind, Randomized, Placebo-controlled Trial Evaluating the Efficacy and Safety of BI 1015550 Over at Least 52 Weeks in Patients With Progressive Fibrosing Interstitial Lung Diseases (PF-ILDs)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study is open to adults with Progressive Fibrosing Interstitial Lung Diseases (PF-ILDs). People who have a form of PF-ILD other than Idiopathic Pulmonary Fibrosis (IPF) can join the study. If they already take nintedanib, they can continue treatment throughout the study. The purpose of this study is to find out whether a medicine called BI 1015550 helps people with PF-ILD. Participants are put into 3 groups randomly, which means by chance. Participants in 2 groups take different doses of BI 1015550 as tablets twice a day. Participants in the placebo group take placebo tablets twice a day. Placebo tablets look like BI 1015550 tablets but do not contain any medicine. Participants are in the study for up to two and a half years. During the first year, they visit the study site 10 times. Afterwards, they visit the study site every 3 months. The doctors regularly test participants' lung function. The results of the lung function tests are compared between the groups. The doctors also regularly check participants' health and take note of any unwanted effects.
Study identification
- NCT ID
- NCT05321082
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,178 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 16, 2022 (Actual)
- Primary completion
- Dec 18, 2024 (Actual)
- Completion
- Apr 14, 2025 (Actual)
- Last update posted
- Jan 9, 2026
2022 – 2025
United States locations
- U.S. sites
- 59
- U.S. states
- 32
- U.S. cities
- 49
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35233 | — |
| University of Arizona | Tucson | Arizona | 85724 | — |
| University of Southern California | Los Angeles | California | 90033 | — |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | — |
| University of California Los Angeles | Los Angeles | California | 90095 | — |
| University of California Davis | Sacramento | California | 95817 | — |
| National Jewish Health | Denver | Colorado | 80206 | — |
| Yale University School of Medicine | New Haven | Connecticut | 06510 | — |
| Christiana Hospital | Newark | Delaware | 19718 | — |
| St. Francis Medical Institute | Clearwater | Florida | 33765 | — |
| University of Florida Health Shands Hospital | Gainesville | Florida | 32610 | — |
| Clinical Research Specialists LLC | Kissimmee | Florida | 34746 | — |
| Advanced Pulmonary Research Institute | Loxahatchee Groves | Florida | 33470 | — |
| Destin Pulmonary Critical Care | Santa Rosa Beach | Florida | 32459 | — |
| Piedmont Physicians Pulmonary & Sleep Medicine of Buckhead | Atlanta | Georgia | 30309 | — |
| The Emory Clinic | Atlanta | Georgia | 30322 | — |
| Evanston Hospital Pulmonary Clinic | Evanston | Illinois | 60201 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| Tulane University Hospital and Clinic | New Orleans | Louisiana | 70112 | — |
| Johns Hopkins Hospital | Baltimore | Maryland | 21224 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| St. Elizabeth's Medical Center | Boston | Massachusetts | 02135 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Infinity Medical Research | North Dartmouth | Massachusetts | 02747 | — |
| University of Michigan Health System | Ann Arbor | Michigan | 48109-5314 | — |
| Beaumont Health | Royal Oak | Michigan | 48073 | — |
| University of Minnesota | Minneapolis | Minnesota | 55455 | — |
| Mayo Clinic, Rochester | Rochester | Minnesota | 55905 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198 | — |
| Renown Regional Medical Center | Reno | Nevada | 89502 | — |
| Stony Brook University Medical Center | Commack | New York | 11725 | — |
| Lenox Hill Hospital | New York | New York | 10021 | — |
| Columbia University Medical Center-New York Presbyterian Hospital | New York | New York | 10032 | — |
| NewYork-Presbyterian/Weill Cornell Medical Center | New York | New York | 10065 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| Southeastern Research Center-Winston-Salem-61365 | Winston-Salem | North Carolina | 27103 | — |
| University of Cincinnati | Cincinnati | Ohio | 45267 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| The Ohio State University Wexner Medical Center | Columbus | Ohio | 43210 | — |
| The Oregon Clinic | Portland | Oregon | 97220 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | — |
| Jefferson Health Honickman Center | Philadelphia | Pennsylvania | 19107 | — |
| Temple University Hospital | Philadelphia | Pennsylvania | 19140 | — |
| Allegheny General Hospital | Pittsburgh | Pennsylvania | 15212 | — |
| Infinity Medical Research, Inc. | East Providence | Rhode Island | 02914 | — |
| Lowcountry Lung and Critical Care | Charleston | South Carolina | 29406 | — |
| Clinical Trials Center of Middle Tennessee, LLC | Franklin | Tennessee | 37067 | — |
| Vanderbilt University Medical Center - Vanderbilt Lung Institute at 100 Oaks | Nashville | Tennessee | 37204 | — |
| Baylor University Medical Center | Dallas | Texas | 75246 | — |
| Premier Pulmonary Critical Care and Sleep Medicine | Denison | Texas | 75020 | — |
| UT Health San Antonio | San Antonio | Texas | 78229 | — |
| Intermountain Medical Center-Murray-69497 | Murray | Utah | 84107 | — |
| University of Utah Health Sciences Center | Salt Lake City | Utah | 84108 | — |
| University of Vermont | Burlington | Vermont | 05401 | — |
| Inova Fairfax Hospital | Falls Church | Virginia | 22042 | — |
| Virginia Mason Medical Center | Seattle | Washington | 98101 | — |
| University of Wisconsin | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 341 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05321082, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 9, 2026 · Synced Oct 27, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05321082 live on ClinicalTrials.gov.