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Recruiting Phase 2 Interventional

Testing the Combination of the Anti-cancer Drugs ZEN003694 (ZEN-3694) and Talazoparib in Patients With Advanced Solid Tumors, The ComBET Trial

ClinicalTrials.gov ID: NCT05327010

Public ClinicalTrials.gov record NCT05327010. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Apr 29, 2026, 9:14 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Phase 2 Trial of the Combination of the BET Inhibitor, ZEN003694 (ZEN-3694), and the PARP Inhibitor Talazoparib, in Patients With Molecularly-Selected Solid Tumors (ComBET)

Study identification

NCT ID
NCT05327010
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 2
Lead sponsor
National Cancer Institute (NCI)
NIH
Enrollment
88 participants

Conditions and interventions

Interventions

  • BET Bromodomain Inhibitor ZEN-3694 Drug
  • Biopsy Procedure Procedure
  • Biospecimen Collection Procedure
  • Diagnostic Imaging Testing Procedure
  • Talazoparib Drug

Drug · Procedure

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Nov 13, 2022
Primary completion
Dec 30, 2026
Completion
Dec 30, 2027
Last update posted
Apr 13, 2026

2022 – 2027

United States locations

U.S. sites
36
U.S. states
16
U.S. cities
32
Facility City State ZIP Site status
City of Hope Comprehensive Cancer Center Duarte California 91010 Recruiting
City of Hope at Irvine Lennar Irvine California 92618 Recruiting
UC San Diego Moores Cancer Center La Jolla California 92093 Recruiting
Keck Medicine of USC Koreatown Los Angeles California 90020 Active, not recruiting
Los Angeles General Medical Center Los Angeles California 90033 Active, not recruiting
USC / Norris Comprehensive Cancer Center Los Angeles California 90033 Active, not recruiting
USC Norris Oncology/Hematology-Newport Beach Newport Beach California 92663 Active, not recruiting
University of California Davis Comprehensive Cancer Center Sacramento California 95817 Active, not recruiting
UC San Diego Medical Center - Hillcrest San Diego California 92103 Recruiting
UCHealth University of Colorado Hospital Aurora Colorado 80045 Recruiting
Yale University New Haven Connecticut 06520 Active, not recruiting
Smilow Cancer Hospital Care Center-Trumbull Trumbull Connecticut 06611 Active, not recruiting
UF Health Cancer Institute - Gainesville Gainesville Florida 32610 Active, not recruiting
Emory University Hospital/Winship Cancer Institute Atlanta Georgia 30322 Recruiting
Northwestern University Chicago Illinois 60611 Recruiting
University of Kansas Clinical Research Center Fairway Kansas 66205 Recruiting
University of Kansas Cancer Center Kansas City Kansas 66160 Recruiting
University of Kansas Cancer Center-Overland Park Overland Park Kansas 66210 Recruiting
University of Kansas Hospital-Indian Creek Campus Overland Park Kansas 66211 Recruiting
University of Kansas Hospital-Westwood Cancer Center Westwood Kansas 66205 Recruiting
University of Kentucky/Markey Cancer Center Lexington Kentucky 40536 Recruiting
Ochsner Medical Center Jefferson New Orleans Louisiana 70121 Recruiting
National Cancer Institute Developmental Therapeutics Clinic Bethesda Maryland 20892 Recruiting
National Institutes of Health Clinical Center Bethesda Maryland 20892 Active, not recruiting
University of Kansas Cancer Center - North Kansas City Missouri 64154 Recruiting
University of Kansas Cancer Center - Lee's Summit Lee's Summit Missouri 64064 Recruiting
University of Kansas Cancer Center at North Kansas City Hospital North Kansas City Missouri 64116 Suspended
UNC Lineberger Comprehensive Cancer Center Chapel Hill North Carolina 27599 Recruiting
University of Pittsburgh Cancer Institute (UPCI) Pittsburgh Pennsylvania 15232 Recruiting
University of Texas at Austin Austin Texas 78712 Active, not recruiting
University of Texas Medical Branch Galveston Texas 77555-0565 Recruiting
M D Anderson Cancer Center Houston Texas 77030 Recruiting
University of Texas Health Science Center at San Antonio San Antonio Texas 78229 Recruiting
Huntsman Cancer Institute/University of Utah Salt Lake City Utah 84112 Active, not recruiting
University of Virginia Cancer Center Charlottesville Virginia 22908 Recruiting
VCU Massey Comprehensive Cancer Center Richmond Virginia 23298 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT05327010, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Apr 13, 2026 · Synced Apr 29, 2026

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The complete protocol, eligibility criteria, and contact information for NCT05327010 live on ClinicalTrials.gov.

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