Extracellular Vesicle Treatment for Acute Respiratory Distress Syndrome (ARDS) (EXTINGUISH ARDS)
Public ClinicalTrials.gov record NCT05354141. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Bone Marrow Mesenchymal Stem Cell Derived Extracellular Vesicles for Hospitalized Patients With Moderate-to-Severe ARDS: A Phase III Clinical Trial
Study identification
- NCT ID
- NCT05354141
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Direct Biologics, LLC
- Industry
- Enrollment
- 970 participants
Conditions and interventions
Conditions
Interventions
- ExoFlo Biological
- Intravenous normal saline Other
Biological · Other
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 30, 2022
- Primary completion
- Nov 29, 2027
- Completion
- Dec 30, 2027
- Last update posted
- Feb 22, 2026
2022 – 2027
United States locations
- U.S. sites
- 32
- U.S. states
- 20
- U.S. cities
- 32
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Direct Biologics Investigational Site | Phoenix | Arizona | 85012 | Recruiting |
| Direct Biologics Investigational Site | Little Rock | Arkansas | 72205 | Recruiting |
| Direct Biologics Investigational Site | Davis | California | 95817 | Recruiting |
| Direct Biologics Investigational Site | Irvine | California | 92627 | Recruiting |
| Direct Biologics Investigational Site | Sacramento | California | 95817 | Recruiting |
| Direct Biologics Investigational Site | Washington D.C. | District of Columbia | 20010 | Recruiting |
| Direct Biologics Investigational Site | Jacksonville | Florida | 32224 | Recruiting |
| Direct Biologics Investigational Site | Boise | Idaho | 83712 | Recruiting |
| Direct Biologics Investigational Site | Iowa City | Iowa | 52242 | Recruiting |
| Direct Biologics Investigational Site | Silver Spring | Maryland | 20910 | Recruiting |
| Direct Biologics Investigational Site | Boston | Massachusetts | 02115 | Recruiting |
| Direct Biologics Investigational Site | Burlington | Massachusetts | 01805 | Recruiting |
| Direct Biologics Investigational Site | Springfield | Massachusetts | 01199 | Recruiting |
| Direct Biologics Investigational Site | Detroit | Michigan | 48202 | Recruiting |
| Direct Biologics Investigational Site | Rochester | Minnesota | 55905 | Recruiting |
| Direct Biologics Investigational Site | Jackson | Mississippi | 39202 | Recruiting |
| Direct Biologics Investigational Site | Flushing | New York | 11368 | Recruiting |
| Direct Biologics Investigational Site | Queens | New York | 11040 | Recruiting |
| Direct Biologics Investigational Site | The Bronx | New York | 10467 | Recruiting |
| Direct Biologics Investigational Site | Durham | North Carolina | 27710 | Recruiting |
| Direct Biologics Investigational Site | Winston-Salem | North Carolina | 27157 | Recruiting |
| Direct Biologics Investigational Site | Cincinnati | Ohio | 45219 | Recruiting |
| Direct Biologics Investigational Site | Cleveland | Ohio | 44106 | Recruiting |
| Direct Biologics Investigational Site | Portland | Oregon | 97239 | Recruiting |
| Direct Biologics Investigational Site | Charleston | South Carolina | 29425 | Recruiting |
| Direct Biologics Investigational Site | Knoxville | Tennessee | 37996 | Recruiting |
| Direct Biologics Investigational Site | Nashville | Tennessee | 37235 | Recruiting |
| Direct Biologics Investigational Site | Dallas | Texas | 75246 | Recruiting |
| Direct Biologics Investigational Site | Fort Worth | Texas | 76104 | Recruiting |
| Direct Biologics Investigational Site | Houston | Texas | 77030 | Recruiting |
| Direct Biologics Investigational Site | Murray | Utah | 84107 | Not yet recruiting |
| Direct Biologics Investigational Site | Salt Lake City | Utah | 84101 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05354141, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 22, 2026 · Synced May 20, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05354141 live on ClinicalTrials.gov.