A Study of Olezarsen (Formerly Known as AKCEA-APOCIII-LRx) in Adults With Hypertriglyceridemia and Atherosclerotic Cardiovascular Disease (Established or at Increased Risk for), and/or With Severe Hypertriglyceridemia
Public ClinicalTrials.gov record NCT05355402. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-blind, Placebo-Controlled, Phase 2b Study of ISIS 678354 in Patients With Hypertriglyceridemia and Atherosclerotic Cardiovascular Disease (Established or at Increased Risk for), and/or With Severe Hypertriglyceridemia
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of the study was to evaluate the effect of olezarsen on percent change in fasting triglyceride (TG) levels compared to placebo at Months 6 and 12 and the proportion of participants who achieve different thresholds in fasting TG. Other objectives were to evaluate the effect of olezarsen on percent change in fasting apolipoprotein C-III (apoC-III), very low-density lipoprotein cholesterol (VLDL-C), remnant cholesterol, non-high-density lipoprotein cholesterol (non-HDL-C), HDL-C, total cholesterol (TC), apolipoprotein B (apoB), low-density lipoprotein cholesterol (LDL-C), and apolipoprotein A-1 (apoA-1).
Study identification
- NCT ID
- NCT05355402
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 154 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 9, 2022 (Actual)
- Primary completion
- Mar 22, 2023 (Actual)
- Completion
- Dec 21, 2023 (Actual)
- Last update posted
- Apr 23, 2026
2022 – 2023
United States locations
- U.S. sites
- 21
- U.S. states
- 14
- U.S. cities
- 20
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Clinical Trials Research | Lincoln | California | 95648 | — |
| Catalina Research Institute, LLC | Montclair | California | 91763 | — |
| Excel Medical Clinical Trials, LLC | Boca Raton | Florida | 33434 | — |
| De La Cruz Research Center | Miami | Florida | 33184 | — |
| Suncoast Clinical Research, Inc. | New Port Richey | Florida | 34652 | — |
| Research Physicians Network Alliance | Winter Park | Florida | 32792 | — |
| IACT Health | Columbus | Georgia | 31904 | — |
| Evanston Premier Healthcare Research | Evanston | Illinois | 60201 | — |
| Clinical Investigation Specialist | Gurnee | Illinois | 60031 | — |
| West Broadway Clinic | Council Bluffs | Iowa | 51501 | — |
| Louisville Metabolic and Atherosclerosis Research Center (L-MARC) | Louisville | Kentucky | 40213 | — |
| Aa Mrc, Llc | Flint | Michigan | 48504 | — |
| Clinical Research of South Nevada | Las Vegas | Nevada | 89121 | — |
| Palm Research Center, Inc. | Las Vegas | Nevada | 89148 | — |
| Green and Seidner Family Practice Associates | Lansdale | Pennsylvania | 19446 | — |
| Main Street Physicians Care Waterway | Little River | South Carolina | 29566 | — |
| Health Concepts | Rapid City | South Dakota | 57702 | — |
| Tennessee Center for Clinical Trials | Tullahoma | Tennessee | 37388 | — |
| Southern Endocrinology Associates | Mesquite | Texas | 75149 | — |
| Manassas Clinical Research Center | Manassas | Virginia | 20110 | — |
| York Clinical Research LLC | Norfolk | Virginia | 23504 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 3 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05355402, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 23, 2026 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05355402 live on ClinicalTrials.gov.