A Study to Learn About the Study Medicine Called PF-07799933 in People With Advanced Solid Tumors With BRAF Alterations.
Public ClinicalTrials.gov record NCT05355701. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A PHASE 1, OPEN-LABEL, DOSE ESCALATION AND DOSE EXPANSION STUDY TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND ANTI TUMOR ACTIVITY OF PF-07799933 (ARRY-440) AS A SINGLE AGENT AND IN COMBINATION THERAPY IN PARTICIPANTS 16 YEARS AND OLDER WITH ADVANCED SOLID TUMORS WITH BRAF ALTERATIONS
Study identification
- NCT ID
- NCT05355701
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 1
- Lead sponsor
- Pfizer
- Industry
- Enrollment
- 267 participants
Conditions and interventions
Conditions
Interventions
- PF-07799933 Drug
- binimetinib Drug
- cetuximab Biological
- fluorouracil Drug
- leucovorin Drug
- midazolam Drug
- oxaliplatin Drug
Drug · Biological
Eligibility (public fields only)
- Age range
- 16 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 4, 2022
- Primary completion
- Feb 1, 2029
- Completion
- Aug 5, 2030
- Last update posted
- May 4, 2026
2022 – 2030
United States locations
- U.S. sites
- 14
- U.S. states
- 6
- U.S. cities
- 6
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| UCHealth Sue Anschutz-Rodgers Eye Center | Aurora | Colorado | 80045 | Recruiting |
| University of Colorado Hospital - Anschutz Cancer Pavilion (ACP) | Aurora | Colorado | 80045 | Recruiting |
| University of Colorado Hospital - Anschutz Inpatient Pavilion (AIP) | Aurora | Colorado | 80045 | Recruiting |
| University of Colorado Hospital - Anschutz Outpatient Pavilion (AOP) | Aurora | Colorado | 80045 | Recruiting |
| University of Miami Hospital and Clinics | Miami | Florida | 33136 | Recruiting |
| DFCI Chestnut Hill | Newton | Massachusetts | 02459 | Recruiting |
| CT Scan and Echo Only: Henry Ford Medical Center-Plymouth | Plymouth | Michigan | 48170 | Recruiting |
| MSK David H. Koch Center for Cancer Care | New York | New York | 10021 | Recruiting |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | Recruiting |
| Sarah Cannon Research Institute - Pharmacy | Nashville | Tennessee | 37203 | Recruiting |
| SCRI Oncology Partners | Nashville | Tennessee | 37203 | Recruiting |
| TriStar Bone Marrow Transplant | Nashville | Tennessee | 37203 | Recruiting |
| TriStar Centennial Medical Center - Cell Processing Lab | Nashville | Tennessee | 37203 | Recruiting |
| TriStar Centennial Medical center | Nashville | Tennessee | 37203 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 4 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05355701, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 4, 2026 · Synced May 10, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05355701 live on ClinicalTrials.gov.