A Study to Investigate the Efficacy and Safety of an Infusion of IOV-4001 in Adult Participants With Unresectable or Metastatic Melanoma or Stage III or IV Non-small-cell Lung Cancer

ClinicalTrials.gov ID: NCT05361174

Public ClinicalTrials.gov record NCT05361174. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 3, 2026, 4:11 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 1/2, Open-label Study of PD-1 Knockout Tumor-infiltrating Lymphocytes (IOV-4001) in Participants With Unresectable or Metastatic Melanoma or Stage III or IV Non-small-cell Lung Cancer

Study identification

NCT ID: NCT05361174
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1, Phase 2
Lead sponsor: Iovance Biotherapeutics, Inc.; Industry
Enrollment: 53 participants

Conditions and interventions

Conditions

Interventions

IOV-4001 Biological

Biological

Eligibility (public fields only)

Age range: 18 Years to 70 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jul 19, 2022
Primary completion: May 31, 2025
Completion: May 31, 2027
Last update posted: Dec 4, 2024

2022 – 2027

United States locations

U.S. sites: 10
U.S. states: 8
U.S. cities: 10

Facility	City	State	ZIP	Site status
The Angeles Clinic and Research Institute	Los Angeles	California	90025	Recruiting
Sylvester Comprehensive Cancer Center	Miami	Florida	33136	Recruiting
Orlando Health Cancer Institute	Orlando	Florida	32610	Recruiting
Moffitt Cancer Center	Tampa	Florida	33612	Recruiting
The University of Kansas Cancer Center	Westwood	Kansas	66205	Recruiting
University of Louisville	Louisville	Kentucky	40202	Recruiting
Memorial Sloan Kettering Cancer Center	New York	New York	10065	Recruiting
University of Cincinnati	Cincinnati	Ohio	45219	Recruiting
UPMC Hillman Cancer Center	Pittsburgh	Pennsylvania	15232	Recruiting
Medical College of Wisconsin	Milwaukee	Wisconsin	53226	Withdrawn

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05361174, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Dec 4, 2024 · Synced May 3, 2026

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The complete protocol, eligibility criteria, and contact information for NCT05361174 live on ClinicalTrials.gov.

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