Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS

ClinicalTrials.gov ID: NCT05379985

Public ClinicalTrials.gov record NCT05379985. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 5, 2026, 3:44 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Multicenter Open-Label Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS

Study identification

NCT ID: NCT05379985
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1, Phase 2
Lead sponsor: Revolution Medicines, Inc.; Industry
Enrollment: 754 participants

Conditions and interventions

Conditions

Interventions

RMC-6236 Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: May 30, 2022
Primary completion: May 30, 2027
Completion: Jul 25, 2027
Last update posted: Nov 11, 2025

2022 – 2027

United States locations

U.S. sites: 16
U.S. states: 10
U.S. cities: 14

Facility	City	State	ZIP	Site status
UC Irvine/Chao Family Comprehensive Cancer Center	Orange	California	92868	Recruiting
UCLA	Santa Monica	California	90404	Recruiting
Moffitt Cancer Center	Tampa	Florida	33612	Recruiting
Johns Hopkins University	Baltimore	Maryland	21287	Recruiting
Dana Farber Cancer Institute	Boston	Massachusetts	02215	Recruiting
Perlmutter Cancer Center at NYU Langone Health	New York	New York	10016	Recruiting
Memorial Sloan-Kettering Cancer Center	New York	New York	10021	Recruiting
Columbia University	New York	New York	10032	Recruiting
Christ Hospital Cancer Center	Cincinnati	Ohio	45219	Recruiting
Sarah Cannon Research Institute	Nashville	Tennessee	37203	Recruiting
University of Texas at Austin	Austin	Texas	78712	Recruiting
Mary Crowley Cancer Research	Dallas	Texas	75230	Recruiting
The University of Texas MD Anderson Cancer Center	Houston	Texas	77030	Recruiting
Next Oncology	San Antonio	Texas	78229	Recruiting
Huntsman Cancer Institute	Salt Lake City	Utah	84112	Recruiting
Next Oncology Virginia	Fairfax	Virginia	22031	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05379985, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Nov 11, 2025 · Synced May 5, 2026

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The complete protocol, eligibility criteria, and contact information for NCT05379985 live on ClinicalTrials.gov.

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