A Single-Ascending and Repeated Dose Study of LY3849891 in Participants With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)
Public ClinicalTrials.gov record NCT05395481. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Single-Ascending and Repeated Subcutaneous Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LY3849891 in Participants With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Who Have the PNPLA3 I148M Genotype
Study identification
- NCT ID
- NCT05395481
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 1
- Lead sponsor
- Eli Lilly and Company
- Industry
- Enrollment
- 176 participants
Conditions and interventions
Conditions
Interventions
- LY3849891 Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 70 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 7, 2022
- Primary completion
- Apr 30, 2026
- Completion
- Apr 30, 2026
- Last update posted
- Jan 21, 2026
2022 – 2026
United States locations
- U.S. sites
- 13
- U.S. states
- 5
- U.S. cities
- 11
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arizona Liver Health - Chandler | Chandler | Arizona | 85225 | — |
| Orange County Research Center | Orange | California | 92868 | — |
| Inland Empire Clinical Trials, LLC | Rialto | California | 92377 | — |
| Synergy Healthcare LLC | Brandon | Florida | 33511 | — |
| Accel Research Sites - Maitland | Maitland | Florida | 32751 | — |
| Evolution Clinical Trials, Inc | Miami | Florida | 33122 | — |
| Advanced Pharma Clinical Research | Miami | Florida | 33175 | — |
| Floridian Clinical Research | Miami Lakes | Florida | 33016 | — |
| Charter Research - Winter Park | Orlando | Florida | 32803 | — |
| IU Health University Hospital | Indianapolis | Indiana | 46290 | — |
| Houston Research Institute | Houston | Texas | 77079 | — |
| Clinical Trials of Texas, Inc. | San Antonio | Texas | 78229 | — |
| Pinnacle Clinical Research | San Antonio | Texas | 78229 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 3 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05395481, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 21, 2026 · Synced May 20, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05395481 live on ClinicalTrials.gov.