A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Participants With Candidemia and/or Invasive Candidiasis.
Public ClinicalTrials.gov record NCT05421858. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
An Interventional Efficacy and Safety Phase 3 Double-blind 2-arm Study to Investigate IV Followed by Oral Fosmanogepix Compared With IV Caspofungin Followed by Oral Fluconazole in Adult Participants With Candidemia and/or Invasive Candidiasis
Study identification
- NCT ID
- NCT05421858
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Basilea Pharmaceutica
- Industry
- Enrollment
- 450 participants
Conditions and interventions
Conditions
Interventions
- Caspofungin Drug
- Fluconazole Drug
- Fosmanogepix Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 10, 2024
- Primary completion
- Jan 29, 2028
- Completion
- Jan 29, 2028
- Last update posted
- Apr 21, 2026
2024 – 2028
United States locations
- U.S. sites
- 23
- U.S. states
- 14
- U.S. cities
- 20
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham School of Medicine, Department of Medicine | Birmingham | Alabama | 35294-0006 | Recruiting |
| City of Hope | Duarte | California | 91010 | Recruiting |
| David Geffen School of Medicine at UCLA | Los Angeles | California | 90095 | Recruiting |
| UC Davis Medical Center | Sacramento | California | 95817 | Recruiting |
| Emory University Hospital - Clifton Road | Atlanta | Georgia | 30322 | Recruiting |
| Augusta University Medical Center | Augusta | Georgia | 30912-5563 | Recruiting |
| Indiana University Methodist Hospital | Indianapolis | Indiana | 46202 | Recruiting |
| University of Kentucky College of Medicine | Lexington | Kentucky | 40506 | Recruiting |
| Johns Hopkins Hospital | Baltimore | Maryland | 21287 | Recruiting |
| University of Michigan Health System (UMHS) - A. Alfred Taubman Health Care Center | Ann Arbor | Michigan | 48109-5000 | Recruiting |
| DMC Harper University Hospital | Detroit | Michigan | 48201 | Recruiting |
| Henry Ford Hospital, Department of Medicine, Division of Infectious Diseases | Detroit | Michigan | 48202 | Recruiting |
| University of Minnesota | Minneapolis | Minnesota | 55455 | Recruiting |
| Washington University School of Medicine, Infectious Diseases Clinical Research Unit | St Louis | Missouri | 63110 | Recruiting |
| Weill Cornell Medical College - NewYork-Presbyterian Hospital | New York | New York | 10065 | Recruiting |
| University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | 27514 | Recruiting |
| University of Pennsylvania School of Medicine | Philadelphia | Pennsylvania | 19104-6243 | Recruiting |
| UPMC Presbyterian | Pittsburgh | Pennsylvania | 15213-2582 | Recruiting |
| Houston Methodist Hospital - Texas Medical Center | Houston | Texas | 77030 | Recruiting |
| The University of Texas Health Science Center at Houston | Houston | Texas | 77030 | Recruiting |
| U.T. MD Anderson Cancer Center | Houston | Texas | 77030 | Recruiting |
| University of Texas Health Science Center at San Antonio | San Antonio | Texas | 78229 | Recruiting |
| Carilion Clinic | Roanoke | Virginia | 24014 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 115 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05421858, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 21, 2026 · Synced May 18, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05421858 live on ClinicalTrials.gov.