RESPONDER-HF Trial
Public ClinicalTrials.gov record NCT05425459. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Re-Evaluation of the Corvia Atrial Shunt Device in a Precision Medicine Trial to Determine Efficacy in Mildly Reduced or Preserved Ejection Fraction (EF) Heart Failure (Protocol #2201)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Multicenter, Prospective, Randomized, Sham Controlled, Double Blinded Clinical Trial, with; 1:1 randomization
Study identification
- NCT ID
- NCT05425459
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 750 participants
Conditions and interventions
Conditions
Interventions
- Corvia Atrial Shunt System / IASD System II Device
- Intra-cardiac echocardiography (ICE), or transesophageal echocardiography (TEE) Other
Device · Other
Eligibility (public fields only)
- Age range
- 40 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 17, 2022 (Actual)
- Primary completion
- Jul 2027 (Estimated)
- Completion
- Mar 2031 (Estimated)
- Last update posted
- Mar 18, 2026
2022 – 2031
United States locations
- U.S. sites
- 33
- U.S. states
- 22
- U.S. cities
- 31
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arizona Cardiovascular Research Center | Phoenix | Arizona | 85016 | — |
| Scripps Clinic | La Jolla | California | 92037 | — |
| MemorialCare Long Beach Medical Center | Long Beach | California | 90806 | — |
| Christiana Care Health Services | Newark | Delaware | 19718 | — |
| Memorial Regional Hospital | Hollywood | Florida | 33021 | — |
| NCH Naples | Naples | Florida | 34102 | — |
| Cleveland Clinic Florida | Weston | Florida | 33331 | — |
| Northside Hospital Gwinnett Campus | Lawrenceville | Georgia | 30046 | — |
| Wellstar Kennestone | Marietta | Georgia | 30060 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| University of Chicago Medical Center | Chicago | Illinois | 60637 | — |
| Endeavor Health-Northshore | Glenview | Illinois | 60026 | — |
| LSU Health Shreveport | Shreveport | Louisiana | 71103 | — |
| Lahey Hospital & Medical Center | Burlington | Massachusetts | 01805 | — |
| UMass Memorial Hospital University Campus | Worcester | Massachusetts | 01655 | — |
| University of Michigan Health Systems | Ann Arbor | Michigan | 48109 | — |
| Mayo Clinic Rochester | Rochester | Minnesota | 55905 | — |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| Weill Cornell | New York | New York | 10065 | — |
| Christ Hospital | Cincinnati | Ohio | 45219 | — |
| University of Cincinatti Medical Center | Cincinnati | Ohio | 45219 | — |
| Cleveland Clinic OH | Cleveland | Ohio | 44195 | — |
| Ohio State University Wexner medical Center | Columbus | Ohio | 43210 | — |
| St. Francis Hospital (Heart Hospital) | Tulsa | Oklahoma | 74136 | — |
| OHSU Hospital | Portland | Oregon | 97239 | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| Cardiovascular Institute (CVI) Research | Pittsburgh | Pennsylvania | 15212 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29403 | — |
| North Central Heart-Avera | Sioux Falls | South Dakota | 57108 | — |
| Vanderbilt University | Nashville | Tennessee | 37235 | — |
| Baylor St. Luke's Medical Center | Houston | Texas | 77030 | — |
| University of Virginia | Charlottesville | Virginia | 22908 | — |
| West Virginia Heart and Vascular | Morgantown | West Virginia | 26508 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 28 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05425459, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 18, 2026 · Synced Oct 19, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05425459 live on ClinicalTrials.gov.