Testing the Addition of an Anti-cancer Drug, Selinexor, to the Usual Chemotherapy Treatment (Temozolomide) for Brain Tumors That Have Returned After Previous Treatment

ClinicalTrials.gov ID: NCT05432804

Public ClinicalTrials.gov record NCT05432804. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Apr 29, 2026, 8:56 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 1 and Randomized Phase 2 Trial of Selinexor and Temozolomide in Recurrent Glioblastoma

Study identification

NCT ID: NCT05432804
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1, Phase 2
Lead sponsor: National Cancer Institute (NCI); NIH
Enrollment: 97 participants

Conditions and interventions

Conditions

Interventions

Biospecimen Collection Procedure
Magnetic Resonance Imaging Procedure
Placebo Administration Drug
Selinexor Drug
Temozolomide Drug

Procedure · Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Mar 19, 2023
Primary completion: Jun 29, 2027
Completion: Jun 29, 2027
Last update posted: Apr 26, 2026

2023 – 2027

United States locations

U.S. sites: 36
U.S. states: 17
U.S. cities: 31

Facility	City	State	ZIP	Site status
Mayo Clinic Hospital in Arizona	Phoenix	Arizona	85054	Recruiting
City of Hope Comprehensive Cancer Center	Duarte	California	91010	Recruiting
UC San Diego Moores Cancer Center	La Jolla	California	92093	Recruiting
Keck Medicine of USC Koreatown	Los Angeles	California	90020	Recruiting
Los Angeles General Medical Center	Los Angeles	California	90033	Recruiting
USC / Norris Comprehensive Cancer Center	Los Angeles	California	90033	Recruiting
University of California Davis Comprehensive Cancer Center	Sacramento	California	95817	Recruiting
UCHealth University of Colorado Hospital	Aurora	Colorado	80045	Recruiting
UM Sylvester Comprehensive Cancer Center at Coral Gables	Coral Gables	Florida	33146	Recruiting
UM Sylvester Comprehensive Cancer Center at Deerfield Beach	Deerfield Beach	Florida	33442	Recruiting
Mayo Clinic in Florida	Jacksonville	Florida	32224-9980	Recruiting
University of Miami Miller School of Medicine-Sylvester Cancer Center	Miami	Florida	33136	Recruiting
Moffitt Cancer Center	Tampa	Florida	33612	Recruiting
Emory University Hospital Midtown	Atlanta	Georgia	30308	Recruiting
Emory University Hospital/Winship Cancer Institute	Atlanta	Georgia	30322	Recruiting
University of Chicago Comprehensive Cancer Center	Chicago	Illinois	60637	Recruiting
University of Chicago Medicine-Orland Park	Orland Park	Illinois	60462	Recruiting
University of Kentucky/Markey Cancer Center	Lexington	Kentucky	40536	Recruiting
Mayo Clinic in Rochester	Rochester	Minnesota	55905	Recruiting
Saint Barnabas Medical Center	Livingston	New Jersey	07039	Recruiting
Rutgers Cancer Institute of New Jersey	New Brunswick	New Jersey	08903	Recruiting
Rutgers New Jersey Medical School	Newark	New Jersey	07101	Recruiting
Roswell Park Cancer Institute	Buffalo	New York	14263	Active, not recruiting
Laura and Isaac Perlmutter Cancer Center at NYU Langone	New York	New York	10016	Recruiting
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center	New York	New York	10032	Active, not recruiting
Wake Forest University Health Sciences	Winston-Salem	North Carolina	27157	Suspended
University of Cincinnati Cancer Center-UC Medical Center	Cincinnati	Ohio	45219	Recruiting
Ohio State University Comprehensive Cancer Center	Columbus	Ohio	43210	Recruiting
University of Cincinnati Cancer Center-West Chester	West Chester	Ohio	45069	Recruiting
University of Oklahoma Health Sciences Center	Oklahoma City	Oklahoma	73104	Recruiting
University of Pittsburgh Cancer Institute (UPCI)	Pittsburgh	Pennsylvania	15232	Recruiting
Huntsman Cancer Institute/University of Utah	Salt Lake City	Utah	84112	Recruiting
University of Virginia Cancer Center	Charlottesville	Virginia	22908	Active, not recruiting
VCU Massey Comprehensive Cancer Center	Richmond	Virginia	23298	Recruiting
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center	Madison	Wisconsin	53718	Recruiting
University of Wisconsin Carbone Cancer Center - University Hospital	Madison	Wisconsin	53792	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05432804, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 26, 2026 · Synced Apr 29, 2026

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The complete protocol, eligibility criteria, and contact information for NCT05432804 live on ClinicalTrials.gov.

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