A Study of TTI-101 as Monotherapy and in Combination in Participants With Locally Advanced or Metastatic, and Unresectable Hepatocellular Carcinoma
Public ClinicalTrials.gov record NCT05440708. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
REVERT- Liver Cancer: A Phase 1b/2 Multicenter, Open-label Study to Evaluate the Safety and Efficacy of TTI-101 as Monotherapy and in Combination in Participants With Locally Advanced or Metastatic, and Unresectable Hepatocellular Carcinoma
Study identification
- NCT ID
- NCT05440708
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Lead sponsor
- Tvardi Therapeutics, Incorporated
- Industry
- Enrollment
- 193 participants
Conditions and interventions
Conditions
Interventions
- Atezolizumab Drug
- Bevacizumab Drug
- Pembrolizumab Drug
- TTI-101 Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 22, 2023
- Primary completion
- Jan 31, 2027
- Completion
- Mar 9, 2027
- Last update posted
- Apr 26, 2026
2023 – 2027
United States locations
- U.S. sites
- 21
- U.S. states
- 14
- U.S. cities
- 21
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| The Kirklin Clinic of University of Alabama Birmingham Hospital | Birmingham | Alabama | 35233 | Recruiting |
| University of California San Diego | La Jolla | California | 92093 | Completed |
| Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | Recruiting |
| University of California Irvine Medical Center | Orange | California | 92868 | Recruiting |
| University of Colorado Hospital - Anschutz Medical Campus | Aurora | Colorado | 80045 | Recruiting |
| Georgetown Lombardi Comprehensive Cancer Center | Washington D.C. | District of Columbia | 20007 | Completed |
| Moffitt Cancer Center | Tampa | Florida | 33612 | Recruiting |
| The Sidney Kimmel Comprehensive Cancer Center | Baltimore | Maryland | 21231 | Recruiting |
| University of Michigan Rogel Cancer Center | Ann Arbor | Michigan | 48109 | Recruiting |
| Barbara Ann Karmanos Cancer Institute | Detroit | Michigan | 48201 | Recruiting |
| Washington University in St. Louis | St Louis | Missouri | 63129 | Recruiting |
| Memorial Sloan Kettering Cancer Center - New York | New York | New York | 10065 | Recruiting |
| Cleveland Clinic Lerner College of Medicine | Cleveland | Ohio | 44195 | Recruiting |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | Recruiting |
| Harold C. Simmons Comprehensive Cancer Center | Dallas | Texas | 75390 | Recruiting |
| University of Texas MD Anderson Cancer Center | Houston | Texas | 77030-4000 | Recruiting |
| DHR Health Institute for Research and Development | McAllen | Texas | 78504 | Recruiting |
| University of Texas Health Science Center - San Antonio | San Antonio | Texas | 78229 | Recruiting |
| Virginia Mason Medical Center | Seattle | Washington | 98101 | Recruiting |
| Summit Cancer Centers - North Spokane | Spokane | Washington | 99208 | Recruiting |
| Froedtert and Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | Completed |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05440708, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 26, 2026 · Synced May 5, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05440708 live on ClinicalTrials.gov.