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Recruiting Not applicable Interventional

Platform of Randomized Adaptive Clinical Trials in Critical Illness

ClinicalTrials.gov ID: NCT05440851

Public ClinicalTrials.gov record NCT05440851. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 8, 2026, 8:08 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Study identification

NCT ID
NCT05440851
Recruitment status
Recruiting
Study type
Interventional
Phase
Not applicable
Lead sponsor
University Health Network, Toronto
Other
Enrollment
6,250 participants

Conditions and interventions

Interventions

  • Driving Pressure-Limited Ventilation (DPL) Other
  • Drug 4 mL: Drug
  • Drug 40 mg: Drug
  • Early Cohort corticosteroid dose Drug
  • Early Routine IMT Other
  • Electrical impedance tomography (EIT) Other
  • Extended Cohort corticosteroid dose Drug
  • Lung- and Diaphragm-Protective Ventilation and Sedation (LDPVS) Other
  • Lung-Protective Ventilation (LPV) Other
  • PEEP-10 Other
  • PEEP-20 Other
  • PEEP-AOP Other
  • Ultra-Protective Ventilation Facilitated by Extracorporeal Support Other
  • Usual care Other
  • Usual care with fludrocortisone Drug
  • Usual care without extending corticosteroids Drug
  • Usual care without fludrocortisone Drug
  • Usual care without routine corticosteroids Drug
  • VV ECMO-facilitated strategy of earlier awakening, extubation and rehabilitation Other
  • no treatment / intervention arm is involved. Other

Other · Drug

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Apr 29, 2023
Primary completion
Mar 30, 2027
Completion
Mar 30, 2027
Last update posted
May 6, 2026

2023 – 2027

United States locations

U.S. sites
26
U.S. states
18
U.S. cities
22
Facility City State ZIP Site status
University of Arizona Tucson Arizona 85724 Recruiting
University of California Los Angeles (UCLA) Los Angeles California 90095 Recruiting
University of San Diego (UCSD) San Diego California 92121 Recruiting
University of California San Francisco San Francisco California 94143 Recruiting
University of Colorado Hospital Aurora Colorado 80045 Recruiting
University of Kentucky Lexington Kentucky 40506 Recruiting
University of Maryland Medical System Baltimore Maryland 21201 Recruiting
The Johns Hopkins Medicine Baltimore Maryland 21224 Recruiting
VA Ann Arbor Healthcare System Ann Arbor Michigan 48105 Not yet recruiting
University of Michigan Health Ann Arbor Michigan 48109 Recruiting
Washington University St Louis Missouri 63130 Recruiting
University of Nebraska Medical Center Omaha Nebraska 68198 Recruiting
Mount Sinai New York City New York New York 10029 Recruiting
Columbia University Irving Medical Center New York New York 10032 Recruiting
Wake Forest University School of Medicine Winston-Salem North Carolina 27101 Recruiting
University of Cincinnati College of Medicine Cincinnati Ohio 45267 Recruiting
Cleveland Clinic Cleveland Ohio 44195 Recruiting
Oregon Health & Science University (OHSU) Portland Oregon 97239 Recruiting
University of Pennsylvania Philadelphia Pennsylvania 19104 Recruiting
Thomas Jefferson University Hospital Philadelphia Pennsylvania 19107 Recruiting
University of Pittsburgh Medical Center (UPMC) Pittsburgh Pennsylvania 15213 Recruiting
Rhode Island Hospital Providence Rhode Island 02903 Recruiting
Medical University of South Carolina (MUSC) Charleston South Carolina 29425 Recruiting
Vanderbilt university medical center Nashville Tennessee 37232 Recruiting
University of Utah Health Farmington Utah 84025 Recruiting
Sentara Health Norfolk Virginia 23507 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 63 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT05440851, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted May 6, 2026 · Synced May 8, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05440851 live on ClinicalTrials.gov.

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