ClinicalTrials.gov record
A Study Evaluating the Long-term Safety and Efficacy of VX-121 Combination Therapy
ClinicalTrials.gov ID: NCT05444257
Public ClinicalTrials.gov record NCT05444257. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Open-label Study Evaluating the Long-term Safety and Efficacy of VX-121/TEZ/D-IVA Combination Therapy in Subjects With Cystic Fibrosis
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the long-term safety, tolerability, and efficacy of VX-121/tezacaftor/deutivacaftor (VX-121/TEZ/D-IVA) in participants with cystic fibrosis.
Study identification
- NCT ID
- NCT05444257
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 822 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 12 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 8, 2022 (Actual)
- Primary completion
- Oct 30, 2026 (Estimated)
- Completion
- Oct 30, 2026 (Estimated)
- Last update posted
- Oct 9, 2026
2022 – 2026
United States locations
- U.S. sites
- 72
- U.S. states
- 38
- U.S. cities
- 68
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35233 | — |
| Banner University of Arizona Medical Center | Tucson | Arizona | 85724 | — |
| University of Arkansas for Medical Sciences | Little Rock | Arkansas | 72205 | — |
| Miller Children's Hospital / Long Beach Memorial | Long Beach | California | 90806 | — |
| Children's Hospital Los Angeles | Los Angeles | California | 90027 | — |
| Kaiser Permanente | Oakland | California | 94611 | — |
| University of California Davis Medical Center | Sacramento | California | 95817 | — |
| University of California San Francisco, Lung Transplant Program | San Francisco | California | 94143 | — |
| Children's Hospital of Colorado | Aurora | Colorado | 80045 | — |
| National Jewish Health | Denver | Colorado | 80206 | — |
| University of Florida, Shands Hospital | Gainesville | Florida | 32610 | — |
| Joe DiMaggio Cystic Fibrosis & Pulmonary Center | Hollywood | Florida | 33021 | — |
| University of Miami Miller School of Medicine | Miami | Florida | 33136 | — |
| Central Florida Pulmonary Group,PA | Orlando | Florida | 32803 | — |
| Nemours Children's Specialty Care | Pensacola | Florida | 32514 | — |
| Johns Hopkins All Children's Hospital Outpatient Care Center | St. Petersburg | Florida | 33701 | — |
| The Emory Clinic at Chantilly | Atlanta | Georgia | 30324 | — |
| Augusta University | Augusta | Georgia | 30912 | — |
| St. Luke's Cystic Fibrosis Center of Idaho | Boise | Idaho | 83702 | — |
| Northwestern Memorial Hospital | Chicago | Illinois | 60611 | — |
| Indiana University | Indianapolis | Indiana | 46202 | — |
| Riley Hospital for Children at Indiana University Health | Indianapolis | Indiana | 46202 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| University of Kentucky | Lexington | Kentucky | 40508 | — |
| Tulane Medical Center | New Orleans | Louisiana | 70112 | — |
| Maine Medical Partners | Portland | Maine | 04102 | — |
| Massachusetts General Hospital Cystic Fibrosis Center Clinical Research Center | Boston | Massachusetts | 02114 | — |
| Boston Children's Hospital | Boston | Massachusetts | 02115 | — |
| UMass Memorial Medical Center | Worcester | Massachusetts | 01655 | — |
| Michigan Medicine | Ann Arbor | Michigan | 48109 | — |
| Harper University Hospital | Detroit | Michigan | 48201 | — |
| Spectrum Health Medical Group Adult Cystic Fibrosis Care Center | Grand Rapids | Michigan | 49546 | — |
| University of Minnesota | Minneapolis | Minnesota | 55455 | — |
| Childrens Hospital University of Missouri Health Sciences Center | Columbia | Missouri | 65212 | — |
| The Children's Mercy Hospital | Kansas City | Missouri | 64108 | — |
| Cardinal Glennon Children's Hospital - St. Louis University | St Louis | Missouri | 63104 | — |
| Washington University School of Medicine / St. Louis Children's Hospital | St Louis | Missouri | 63110 | — |
| Billings Clinic | Billings | Montana | 59101 | — |
| Nebraska Medical Center | Omaha | Nebraska | 68114 | — |
| Dartmouth Hitchcock | Manchester | New Hampshire | 03104 | — |
| Morristown Medical Center | Morristown | New Jersey | 07960 | — |
| Albany Medical College, Pulmonary and Critical Care Medicine | Albany | New York | 12208 | — |
| CF Therapeutics Development Center of Western New York | Buffalo | New York | 14203 | — |
| New York Medical College | Hawthorne | New York | 10532 | — |
| Long Island Jewish Medical Center | New Hyde Park | New York | 11040 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| SUNY Upstate Medical University | Syracuse | New York | 13210 | — |
| Atrium Health Levine Children's Hospital | Charlotte | North Carolina | 28207 | — |
| Wake Forest Baptist Health | Winston-Salem | North Carolina | 27104 | — |
| Akron Children's Hospital | Akron | Ohio | 44308 | — |
| Nationwide Children's Hospital | Columbus | Ohio | 43205 | — |
| Dayton Children's Hospital | Dayton | Ohio | 45404 | — |
| ProMedica Toledo Hospital/Toledo Children's Hospital/Pediatric Pulmonary & Cystic Fibrosis Center | Toledo | Ohio | 43606 | — |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Santiago Reyes, M.D. | Oklahoma City | Oklahoma | 73112 | — |
| Oregon Health & Science University | Portland | Oregon | 97239 | — |
| Children's Hospital of Philadelphia | Philadelphia | Pennsylvania | 19104 | — |
| UPMC Children's Hospital of Pittsburgh | Pittsburgh | Pennsylvania | 15224 | — |
| Prisma Health Richland Campus | Columbia | South Carolina | 29203 | — |
| Sanford Children's Speciality Clinic | Sioux Falls | South Dakota | 57105 | — |
| University of Tennessee Medical Center | Knoxville | Tennessee | 37920 | — |
| Vanderbilt University Medical Center, Nephrology Clinical Trials Center | Nashville | Tennessee | 37232 | — |
| The University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Cook Children's Health Care System | Fort Worth | Texas | 76104 | — |
| Texas Children's Hospital - Baylor College of Medicine | Houston | Texas | 77030 | — |
| University of Utah | Salt Lake City | Utah | 84132 | — |
| Vermont Lung Center | Colchester | Vermont | 05446 | — |
| University of Virginia Health System | Charlottesville | Virginia | 22908 | — |
| University of Washington Medical Center | Seattle | Washington | 98195 | — |
| Providence Pediatric Pulmonary & Cystic Fibrosis Clinic | Spokane | Washington | 99204 | — |
| West Virginia University | Morgantown | West Virginia | 26506 | — |
| University Hospital and UW Health Clinics | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 123 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05444257, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 9, 2026 · Synced Oct 17, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05444257 live on ClinicalTrials.gov.