Evexomostat Plus PI3K or AKT Inhibitor and Fulvestrant in Patients With a PI3K Alteration and HR+/Her2- Breast Cancer

ClinicalTrials.gov ID: NCT05455619

Public ClinicalTrials.gov record NCT05455619. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 5, 2026, 11:40 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Study to Assess the Safety and Efficacy of Evexomostat (SDX-7320) in Combination With A PI3K or Akt Inhibitor Plus Fulvestrant in Patients With HR+, HER2-, Metastatic Breast Cancer With PI3K Pathway Alteration(s)

Study identification

NCT ID: NCT05455619
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1, Phase 2
Lead sponsor: SynDevRx, Inc.; Industry
Enrollment: 52 participants

Conditions and interventions

Conditions

Interventions

Evexomostat Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Aug 25, 2022
Primary completion: Nov 30, 2026
Completion: Feb 28, 2027
Last update posted: Apr 21, 2026

2022 – 2027

United States locations

U.S. sites: 10
U.S. states: 8
U.S. cities: 10

Facility	City	State	ZIP	Site status
Loma Linda University Cancer Center	Loma Linda	California	92354	Recruiting
Hoag Memorial Hospital Presbyterian	Newport	California	92663	Recruiting
SHARP Healthcare	San Diego	California	92123	Recruiting
Miami Cancer Institute at Baptist Health	Miami	Florida	33176	Recruiting
Hope and Healing Cancer Services	Hinsdale	Illinois	60521	Recruiting
Trinity Health	Ypsilanti	Michigan	48197	Recruiting
Cleveland Clinic	Cleveland	Ohio	44195	Recruiting
Penn State Milton S Hershey Medical Center	Hershey	Pennsylvania	17033	Recruiting
Vanderbilt University Medical Center	Nashville	Tennessee	37232	Recruiting
Doctors Hospital of Laredo	Laredo	Texas	78045	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05455619, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 21, 2026 · Synced May 5, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05455619 live on ClinicalTrials.gov.

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