A Study of Aticaprant as Adjunctive Therapy in Adult Participants With Major Depressive Disorder (MDD) With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapy
Public ClinicalTrials.gov record NCT05455684. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-blind, Multicenter, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy, Safety, and Tolerability of Aticaprant 10 mg as Adjunctive Therapy in Adult Participants With Major Depressive Disorder (MDD) With Moderate-to-severe Anhedonia and Inadequate Response to Current Antidepressant Therapy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the efficacy of aticaprant compared with placebo as adjunctive therapy to an antidepressant in improving depressive symptoms in adult participants with major depressive disorder (MDD) with moderate-to-severe anhedonia (ANH+) who have had an inadequate response to current antidepressant therapy with a selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI).
Study identification
- NCT ID
- NCT05455684
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 513 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 74 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 22, 2022 (Actual)
- Primary completion
- Sep 18, 2024 (Actual)
- Completion
- Sep 18, 2024 (Actual)
- Last update posted
- Nov 6, 2025
2022 – 2024
United States locations
- U.S. sites
- 46
- U.S. states
- 16
- U.S. cities
- 40
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| SW Biomedical Research LLC | Tucson | Arizona | 85712 | — |
| University of Arizona | Tucson | Arizona | 85713 | — |
| Advanced Research Center Inc | Anaheim | California | 92805 | — |
| Proscience Research Group | Culver City | California | 90230 | — |
| Behavioral Research Specialists LLC | Glendale | California | 91206 | — |
| Asclepes Research | Long Beach | California | 90807 | — |
| Excell Research Inc | Oceanside | California | 92056 | — |
| Syrentis Clinical Research | Santa Ana | California | 92705 | — |
| Viking Clinical Research Ltd | Temecula | California | 92591 | — |
| University of Connecticut Health Center | Farmington | Connecticut | 06030 | — |
| Innovative Research of West Florida, Incorporated | Clearwater | Florida | 33756 | — |
| Vertex Research Group, Inc | Clermont | Florida | 34711 | — |
| Gulfcoast Medical Research Center | Fort Myers | Florida | 33912 | — |
| New Life Medical Research Center, Inc. | Hialeah | Florida | 33012 | — |
| Amedica Research Institute Inc | Hialeah | Florida | 33013 | — |
| Convenient Medical Center | Hialeah | Florida | 33013 | — |
| Galiz Research | Hialeah | Florida | 33016 | — |
| Pharmax Research Clinic Inc | Miami | Florida | 33126 | — |
| A Plus Research | Miami | Florida | 33144 | — |
| Meridian International Research | Miami Gardens | Florida | 33014 | — |
| University of Miami | Miami Lakes | Florida | 33016 | — |
| Medical Research Group of Central Florida | Orange City | Florida | 32763 | — |
| USF, Department of Psychiatry and Behavioral Neurosciences | Tampa | Florida | 33613 | — |
| Research Network America | Berwyn | Illinois | 60402 | — |
| Chicago Research Center | Chicago | Illinois | 60634 | — |
| University of Kansas Medical Center Research Institute | Kansas City | Kansas | 66160 | — |
| Clinical Trials of America | Monroe | Louisiana | 71203 | — |
| ActivMed Practices and Research | Methuen | Massachusetts | 01844 | — |
| Psychiatric Care and Research Center (PCRC) | O'Fallon | Missouri | 63368 | — |
| Bioscience Research LLC | Mount Kisco | New York | 10549 | — |
| Fieve Clinical Research Inc | New York | New York | 10168 | — |
| Finger Lakes Clinical Research | Rochester | New York | 14618 | — |
| Montefiore Medical Center PRIME | The Bronx | New York | 10467 | — |
| Patient Priority Clinical Sites LLC | Cincinnati | Ohio | 45215 | — |
| University of Cincinnati Medical Center | Cincinnati | Ohio | 45219 | — |
| Midwest Clinical Research Center | Dayton | Ohio | 45417 | — |
| Charak Center for Health and Wellness | Garfield Heights | Ohio | 44125 | — |
| Suburban Research Associates | Media | Pennsylvania | 19063 | — |
| University of Pennsylvania - Perelman School of Medicine | Philadelphia | Pennsylvania | 19104 | — |
| West Houston Clinical Research Service | Bellaire | Texas | 77401 | — |
| North Texas Clinical Trials | Fort Worth | Texas | 76104 | — |
| Bay Area Clinical Services | Friendswood | Texas | 77546 | — |
| Clinical Trial Network - Houston | Houston | Texas | 77074 | — |
| Alpine Research Organization | Clinton | Utah | 84015 | — |
| University of Virginia | Charlottesville | Virginia | 22903 | — |
| Northwest Clinical Research Center | Bellevue | Washington | 98007 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 74 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05455684, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 6, 2025 · Synced Oct 28, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05455684 live on ClinicalTrials.gov.