ClinicalTrials.gov record
To Evaluate Efficacy and Safety of Serplulimab + Chemotherapy (Carboplatin- Etoposide) in US Patients With ES-SCLC
ClinicalTrials.gov ID: NCT05468489
Public ClinicalTrials.gov record NCT05468489. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced Apr 22, 2026, 7:11 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Open-label Study of Serplulimab Plus Chemotherapy (Carboplatin-Etoposide) in Comparison With Atezolizumab Plus Chemotherapy in Previously Untreated US Patients With Extensive Stage Small Cell Lung Cancer (ES-SCLC) (ASTRIDE)
Study identification
- NCT ID
- NCT05468489
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Shanghai Henlius Biotech
- Industry
- Enrollment
- 200 participants
Conditions and interventions
Conditions
Interventions
- Atezolizumab + chemotherapy (carboplatin-etoposide) Drug
- Serplulimab + chemotherapy (carboplatin-etoposide) Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Not listed
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 17, 2022
- Primary completion
- Feb 27, 2026
- Completion
- Dec 30, 2027
- Last update posted
- Oct 20, 2025
2022 – 2027
United States locations
- U.S. sites
- 67
- U.S. states
- 30
- U.S. cities
- 64
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Alabama Oncology | Birmingham | Alabama | 35223 | — |
| City of Hope - Phoenix | Goodyear | Arizona | 85338 | — |
| Arizona Clinical Research Center (ACRC) | Tucson | Arizona | 85715 | — |
| Highlands Oncology Group | Springdale | Arkansas | 72762 | — |
| Compassionate Care Research Group | Fountain Valley | California | 92708 | — |
| Providence Medical Foundation | Fullerton | California | 92835 | — |
| Los Angeles Cancer Network | Glendale | California | 91204 | — |
| OPN - Oncology Physician Network | Los Alamitos | California | 90720 | — |
| Kaiser Permanente Research (Southern California) | Los Angeles | California | 90034 | — |
| UC Davis | Sacramento | California | 95817 | — |
| UCHealth Memorial Hospital North | Colorado Springs | Colorado | 80920 | — |
| Banner MD Anderson Cancer Center (BMDACC) | Greeley | Colorado | 80631 | — |
| MD Anderson- North Colorado Medical Center | Greeley | Colorado | 80631 | — |
| Advanced Cancer Treatment Centers | Brooksville | Florida | 34613 | — |
| Cancer Specialists North Florida | Jacksonville | Florida | 32256 | — |
| Mount Sinai Comprehensive Cancer Center | Miami | Florida | 33140 | — |
| Florida Cancer Affiliates- (Ocala Oncology - Main) | Ocala | Florida | 34473 | — |
| Mid Florida Hematology and Oncology Center | Orange City | Florida | 32763 | — |
| BRCR Global | Plantation | Florida | 33322 | — |
| Napa Research | Pompano Beach | Florida | 33064 | — |
| Advanced Research | Tamarac | Florida | 33321 | — |
| City of Hope- Chicago | Chicago | Illinois | 60099 | — |
| Cancer Center of Decatur | Decatur | Illinois | 62526 | — |
| Accellacare of Duly | Tinley Park | Illinois | 60487 | — |
| Northwest Cancer Centers | Dyer | Indiana | 46311 | — |
| Cancer Center of Kansas | Wichita | Kansas | 67214 | — |
| Baptist Health Lexington | Lexington | Kentucky | 40503 | — |
| Pikeville Hospital | Pikeville | Kentucky | 41501 | — |
| CHRISTUS St. Frances Cabrini Cancer Center | Alexandria | Louisiana | 71301 | — |
| Pontchartrain Cancer Center | Hammond | Louisiana | 70433 | — |
| Lahey Hospital & Medical Center | Burlington | Massachusetts | 01805 | — |
| Henry Ford Health Providence Southfield Hospital | Southfield | Michigan | 48075 | — |
| Health Partners Cancer Center at Regions Hospital | Saint Paul | Minnesota | 55101 | — |
| Hattiesburg Clinic Hematology/Oncology | Hattiesburg | Mississippi | 39401 | — |
| North Mississippi Medical Center Hematology and Oncology Clinic | Tupelo | Mississippi | 38801 | — |
| MidAmerica Division Inc., c/o Research Medical Center | Kansas City | Missouri | 64132 | — |
| Lake Regional | Osage Beach | Missouri | 65065 | — |
| St. Vincent Frontier Cancer Center | Billings | Montana | 59102 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68106 | — |
| Renown Health | Reno | Nevada | 89502 | — |
| Dartmouth Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | — |
| Regional Cancer Care Associates LLC RCCA | Freehold | New Jersey | 03756 | — |
| Jersey Shore University Medical Center | Neptune City | New Jersey | 07753 | — |
| Elmhurst (BRANY site) | Elmhurst | New York | 11373 | — |
| Northwell Health | Lake Success | New York | 11042 | — |
| Stony Brook Cancer Center | Stony Brook | New York | 11794 | — |
| Great Lakes Cancer Care (Kaleida Health) | Williamsville | New York | 14221 | — |
| Summa Health | Akron | Ohio | 44304 | — |
| Cleveland Clinic Mercy Hospital | Canton | Ohio | 44708 | — |
| Aultman Cancer Center | Canton | Ohio | 44710 | — |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | — |
| Tricounty Hematology and Oncology Associates | Massillon | Ohio | 44646 | — |
| CharterCARE (Roger Williams) | Providence | Rhode Island | 02908 | — |
| Monument Health | Rapid City | South Dakota | 57701 | — |
| CHRISTUS Institute for Innovation & Advanced Clinical Care | Corpus Christi | Texas | 78404 | — |
| DHR Research | Edinburg | Texas | 78539 | — |
| Millennium Research and Clinical Development | Houston | Texas | 77090 | — |
| Lumi Research | Kingwood | Texas | 77339 | — |
| Joe Arrington Cancer Research and Treatment Center | Lubbock | Texas | 79410 | — |
| The University of Texas Health Science Center at Tyler/HOPE Cancer Center | Tyler | Texas | 75701 | — |
| Utah Cancer Specialists | Salt Lake City | Utah | 84106 | — |
| Huntsman Cancer Institute | Salt Lake City | Utah | 84112 | — |
| American Oncology Network Vista Oncology Division | Olympia | Washington | 98502 | — |
| Northwest Medical Specialties, PLLC | Tacoma | Washington | 98405 | — |
| West Virginia University Cancer Institute | Morgantown | West Virginia | 26505 | — |
| University of Wisconsin Carbone Cancer Center | Madison | Wisconsin | 53792 | — |
| Froedtert Hospital- Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05468489, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 20, 2025 · Synced Apr 22, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05468489 live on ClinicalTrials.gov.