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Recruiting Phase 1 Interventional

Tagraxofusp in Pediatric Patients With Relapsed or Refractory CD123 Expressing Hematologic Malignancies

ClinicalTrials.gov ID: NCT05476770

Public ClinicalTrials.gov record NCT05476770. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Apr 22, 2026, 8:59 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase I Study of Tagraxofusp With or Without Chemotherapy in Pediatric Patients With Relapsed or Refractory CD123 Expressing Hematologic Malignancies

Study identification

NCT ID
NCT05476770
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 1
Lead sponsor
Therapeutic Advances in Childhood Leukemia Consortium
Other
Enrollment
54 participants

Conditions and interventions

Interventions

  • Azacitidine Drug
  • Cytarabine Drug
  • Cytarabine IT Drug
  • Dexamethasone Drug
  • Fludarabine Drug
  • Hydrocortisone Drug
  • Methotrexate Drug
  • Tagraxofusp Drug
  • Vincristine Drug

Drug

Eligibility (public fields only)

Age range
1 Year to 21 Years
Sex
All
Healthy volunteers
Not listed

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Nov 10, 2022
Primary completion
Nov 10, 2025
Completion
Nov 10, 2027
Last update posted
Dec 5, 2024

2022 – 2027

United States locations

U.S. sites
29
U.S. states
21
U.S. cities
28
Facility City State ZIP Site status
Children's Hospital Los Angeles Los Angeles California 90027 Recruiting
Children's Hospital Orange County Orange California 92868 Not yet recruiting
UCSF School of Medicine San Francisco California 94143-0106 Recruiting
Children's Hospital Colorado Denver Colorado 80045 Recruiting
Children's National Medical Center Washington D.C. District of Columbia 20010 Recruiting
University of Miami Miami Florida 33136 Not yet recruiting
Children's Healthcare of Atlanta, Emory University Atlanta Georgia 30322 Not yet recruiting
Ann & Robert H. Lurie Children's Hospital of Chicago Chicago Illinois 60611 Recruiting
Riley Hospital for Children Indianapolis Indiana 46202 Recruiting
Johns Hopkins University Baltimore Maryland 21231 Not yet recruiting
National Cancer Institute, Pediatric Oncology Branch Bethesda Maryland 20892 Not yet recruiting
Dana-Farber Cancer Institute Boston Massachusetts 02215 Not yet recruiting
C.S. Mott Children's Hospital Ann Arbor Michigan 48109-0914 Recruiting
Children's Hospital and Clinics of Minnesota Minneapolis Minnesota 55404 Not yet recruiting
Children's Hospital New York-Presbyterian New York New York 10032 Not yet recruiting
Memorial Sloan Kettering Cancer Center New York New York 10065 Recruiting
Carolina-Levine Children's Hospital Charlotte North Carolina 28204 Not yet recruiting
Cincinnati Children's Hospital Medical Center Cincinnati Ohio 45229 Recruiting
Rainbow Babies Cleveland Ohio 44106 Not yet recruiting
Nationwide Children's Hospital Columbus Ohio 43205 Not yet recruiting
Oregon Health & Science University Portland Oregon 97239 Not yet recruiting
Children's Hospital of Philadelphia Philadelphia Pennsylvania 19104 Not yet recruiting
St. Jude Children's Research Hospital Memphis Tennessee 38105 Not yet recruiting
University of Texas, Southwestern Dallas Texas 75235 Recruiting
Cook Children's Hospital Fort Worth Texas 76104 Recruiting
Texas Children's Hospital/Baylor College of Medicine Houston Texas 77030 Recruiting
Primary Children's Hospital Salt Lake City Utah 84113 Recruiting
Seattle Children's Hospital Seattle Washington 98105 Not yet recruiting
Children's Hospital of Wisconsin Milwaukee Wisconsin 53226 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 2 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT05476770, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Dec 5, 2024 · Synced Apr 22, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05476770 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →