Efficacy and Safety of HSK3486 Compared to Propofol for Adults Undergoing Elective Surgery With General Anesthesia
Public ClinicalTrials.gov record NCT05478174. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Multicenter, Randomized, Double-blinded, Propofol-controlled, Phase 3 Clinical Study to Evaluate the Efficacy and Safety of HSK3486 Injectable Emulsion for Induction of General Anesthesia in Adults Undergoing Elective Surgery
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
To demonstrate HSK3486 0.4/0.2 mg/kg (0.4 mg/kg intravenous \[IV\] slow injection over 30 \[±5\] seconds for the first dose, an additional 0.2 mg/kg if needed) is non-inferior to propofol 2.0/1.0 mg/kg (2.0 mg/kg IV slow injection over 30 \[±5\] seconds for first dose, an additional 1.0 mg/kg if needed) in success of induction of general anesthesia in adults undergoing elective surgery.
Study identification
- NCT ID
- NCT05478174
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 400 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 99 Years
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 26, 2022 (Actual)
- Primary completion
- Nov 7, 2023 (Actual)
- Completion
- Nov 14, 2023 (Actual)
- Last update posted
- Oct 10, 2025
2022 – 2023
United States locations
- U.S. sites
- 23
- U.S. states
- 13
- U.S. cities
- 22
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Shoals Medical Trials, Inc. | Sheffield | Alabama | 35660 | — |
| Arizona Research Center | Phoenix | Arizona | 85053 | — |
| UC Davis Health | Davis | California | 95616 | — |
| Coastal Clinical Research Specialists | Jacksonville | Florida | 32250 | — |
| University of Miami Hospital | Miami | Florida | 33136 | — |
| Gulfcoast Research Institute, Llc | Sarasota | Florida | 34232 | — |
| Phoenix Clinical Research | Tamarac | Florida | 33321 | — |
| ForCare Clinical Research | Tampa | Florida | 33613 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| NextStage Clinical Research - Abay Neuroscience Center | Wichita | Kansas | 67226 | — |
| Chesapeake Research Group, Llc | Pasadena | Maryland | 21122 | — |
| Brigham & Women'S Hospital | Boston | Massachusetts | 02115 | — |
| Duke University Health | Durham | North Carolina | 27710 | — |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | — |
| The Ohio State University Wexner Medical Center | Columbus | Ohio | 43210 | — |
| Midwest Clinical Research Center | Dayton | Ohio | 45417 | — |
| Oregon Health & Science University | Portland | Oregon | 97239 | — |
| HD Research | Bellaire | Texas | 77401 | — |
| Hd Research Llc. | Carrollton | Texas | 75006 | — |
| The University of Texas - MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| Urology San Antonio Research | San Antonio | Texas | 78229 | — |
| Endeavor Clinical Trials | San Antonio | Texas | 78240 | — |
| Jbr Clinical Research | Salt Lake City | Utah | 84107 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05478174, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 10, 2025 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05478174 live on ClinicalTrials.gov.