Safety and Efficacy of HSK3486 Compared to Propofol for Induction of General Anesthesia in Adults With Elective Surgery
Public ClinicalTrials.gov record NCT05486416. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Global Multicenter, Randomized, Double-blinded, Propofol-controlled, Phase 3 Clinical Study to Evaluate the Efficacy and Safety of HSK3486 Injectable Emulsion for Induction of General Anesthesia in Adults Undergoing Elective Surgery
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
To demonstrate HSK3486 0.4/0.2 mg/kg (0.4 mg/kg intravenous \[IV\] slow injection over 30 \[±5\] seconds for the first dose, an additional 0.2 mg/kg if needed) is non-inferior to Propofol 2.0/1.0 mg/kg (2.0 mg/kg IV slow injection over 30 \[±5\] seconds for first dose, an additional 1.0 mg/kg if needed) in success of induction of general anesthesia in adults undergoing elective surgery.
Study identification
- NCT ID
- NCT05486416
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 465 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 99 Years
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 12, 2024 (Actual)
- Primary completion
- Jul 23, 2024 (Actual)
- Completion
- Jul 23, 2024 (Actual)
- Last update posted
- Oct 10, 2025
2024
United States locations
- U.S. sites
- 21
- U.S. states
- 10
- U.S. cities
- 18
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| North Alabama Medical Center | Florence | Alabama | 35630 | — |
| Helen Keller Hospital | Sheffield | Alabama | 35660 | — |
| University of Miami Hospital | Miami | Florida | 33136 | — |
| Gulfcoast Research Institute | Sarasota | Florida | 34232 | — |
| Phoenix Clinical Research, LLC | Tamarac | Florida | 33321 | — |
| ForCare Clinical Research | Tampa | Florida | 33613 | — |
| Atlanta Center for Medical Research | Atlanta | Georgia | 30331 | — |
| EBGS Clinical Research Center | Snellville | Georgia | 30078 | — |
| University of Iowa Hospitals and Clinics (Dept of Anesthesia) | Iowa City | Iowa | 52242 | — |
| U of L Health, University of Louisville Hospital | Louisville | Kentucky | 40202 | — |
| The Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| Michigan Medicine | Ann Arbor | Michigan | 48109 | — |
| M3-Emerging Medical Research, LLC | Durham | North Carolina | 27704 | — |
| Duke University Medical Center (DUMC) | Durham | North Carolina | 27710 | — |
| The Ohio State University Wexner Medical Center - University Hospital | Columbus | Ohio | 43210 | — |
| First Surgical Hospital | Bellaire | Texas | 77401 | — |
| Legent Orthopedic Hospital | Carrollton | Texas | 75006 | — |
| The University of Texas MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| Memorial Hermann Village | Houston | Texas | 77043 | — |
| Clinical Trials of Texas, LLC | San Antonio | Texas | 78229 | — |
| Endeavor Clinical Trials, LLC | San Antonio | Texas | 78240 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 7 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05486416, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 10, 2025 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT05486416 live on ClinicalTrials.gov.