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Recruiting Phase 2 Interventional

A Study of LBP-EC01 in the Treatment of Acute Uncomplicated UTI Caused by Drug Resistant E. Coli (ELIMINATE Trial)

ClinicalTrials.gov ID: NCT05488340

Public ClinicalTrials.gov record NCT05488340. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 6, 2026, 11:52 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 2, Double-blind, Randomized, Active-controlled Evaluation of the Safety, Tolerability, Pharmacokinetics and Efficacy of LBP-EC01 in the Treatment of Acute Uncomplicated Urinary Tract Infection Caused by Drug Resistant E. Coli

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This is a Phase 2 superiority study of LBP-EC01, a recombinant bacteriophage cocktail, with an initial open-label 3-arm pharmacokinetic (PK) lead-in portion of 30 patients to evaluate the optimal dosing regimen to be used in the subsequent 288 patient blinded portion of the study which will be randomized 1:1 comparing LBP-EC01 + antibiotic versus placebo + antibiotic in patients with a history of prior urinary tract infection (UTI) cased by E. coli. All patients will be required to have an active acute uncomplicated UTI at baseline.

Study identification

NCT ID
NCT05488340
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 2
Lead sponsor
Locus Biosciences
Industry
Enrollment
318 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years to 75 Years
Sex
Female
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jul 12, 2022
Primary completion
May 31, 2026
Completion
Nov 30, 2026
Last update posted
Mar 19, 2026

2022 – 2026

United States locations

U.S. sites
17
U.S. states
5
U.S. cities
16
Facility City State ZIP Site status
Research Site 138 Fresno California 93710 Completed
Research Site 131 Lancaster California 93534 Recruiting
Research Site 123 Los Angeles California 90027 Recruiting
Research Site 125 Montebello California 90640 Completed
Research Site 152 Murrieta California 92563 Recruiting
Research Site 137 San Diego California 92037 Recruiting
Research Site 126 Tustin California 92780 Recruiting
Research Site 102 Doral Florida 33166 Recruiting
Research Site 151 Hialeah Florida 33013 Recruiting
Research Site 140 Jensen Beach Florida 34957 Completed
Research Site 103 Miami Florida 33176 Recruiting
Research Site 149 Miami Florida 33176 Recruiting
Research Site 153 Ocala Florida 34473 Recruiting
Research Site 120 Boston Massachusetts 02115 Completed
Research Site 154 St Louis Missouri 63141 Recruiting
Research Site 145 Raleigh North Carolina 27708 Recruiting
Research Site 118 Winston-Salem North Carolina 27157 Completed

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT05488340, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Mar 19, 2026 · Synced Sep 6, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05488340 live on ClinicalTrials.gov.

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